English
Related papers

Related papers: Reinforcement learning for robust dynamic metaboli…

200 papers

The aim of multi-task reinforcement learning is two-fold: (1) efficiently learn by training against multiple tasks and (2) quickly adapt, using limited samples, to a variety of new tasks. In this work, the tasks correspond to reward…

Machine Learning · Computer Science 2019-11-05 Nicholas C. Landolfi , Garrett Thomas , Tengyu Ma

Reinforcement learning (RL) is a flexible and efficient method for programming micro-robots in complex environments. Here we investigate whether reinforcement learning can provide insights into biological systems when trained to perform…

Biological Physics · Physics 2024-04-03 Samuel Tovey , Christoph Lohrmann , Christian Holm

Machine-learning techniques are emerging as a valuable tool in experimental physics, and among them, reinforcement learning offers the potential to control high-dimensional, multistage processes in the presence of fluctuating environments.…

Evolutionary algorithms, such as Differential Evolution, excel in solving real-parameter optimization challenges. However, the effectiveness of a single algorithm varies across different problem instances, necessitating considerable efforts…

Neural and Evolutionary Computing · Computer Science 2024-03-08 Hongshu Guo , Yining Ma , Zeyuan Ma , Jiacheng Chen , Xinglin Zhang , Zhiguang Cao , Jun Zhang , Yue-Jiao Gong

Constraint-based optimization is a cornerstone of robotics, enabling the design of controllers that reliably encode task and safety requirements such as collision avoidance or formation adherence. However, handcrafted constraints can fail…

Robotics · Computer Science 2025-08-05 Michael Amir , Guang Yang , Zhan Gao , Keisuke Okumura , Heedo Woo , Amanda Prorok

Soft robotic manipulators offer operational advantage due to their compliant and deformable structures. However, their inherently nonlinear dynamics presents substantial challenges. Traditional analytical methods often depend on simplifying…

Robotics · Computer Science 2024-10-28 Uljad Berdica , Matthew Jackson , Niccolò Enrico Veronese , Jakob Foerster , Perla Maiolino

In this paper, we propose a reinforcement learning-based algorithm for trajectory optimization for constrained dynamical systems. This problem is motivated by the fact that for most robotic systems, the dynamics may not always be known.…

Machine Learning · Statistics 2020-03-05 Kei Ota , Devesh K. Jha , Tomoaki Oiki , Mamoru Miura , Takashi Nammoto , Daniel Nikovski , Toshisada Mariyama

We deploy a combination of reinforcement learning-based approaches and more traditional optimization techniques to identify optimal protocols for population transfer in a multi-level system. We constraint our strategy to the case of fixed…

Reinforcement learning presents an attractive paradigm to reason about several distinct aspects of sequential decision making, such as specifying complex goals, planning future observations and actions, and critiquing their utilities.…

Machine Learning · Computer Science 2023-10-31 Siyan Zhao , Aditya Grover

Reinforcement learning has emerged as a promising methodology for training robot controllers. However, most results have been limited to simulation due to the need for a large number of samples and the lack of automated-yet-safe data…

Robotics · Computer Science 2018-03-29 Kendall Lowrey , Svetoslav Kolev , Jeremy Dao , Aravind Rajeswaran , Emanuel Todorov

Resource Balance Analysis (RBA) is a framework for predicting steady-state cellular growth under resource constraints. However, classical RBA formulations are static and do not capture the dynamic regulation of biosynthetic resources or…

Optimization and Control · Mathematics 2026-01-21 Saeed Sadeghi Arjmand

Learning high-performance control policies that remain consistent with expert behavior is a fundamental challenge in robotics. Reinforcement learning can discover high-performing strategies but often departs from desirable human behavior,…

Robotics · Computer Science 2026-04-06 Siwei Ju , Jan Tauberschmidt , Oleg Arenz , Peter van Vliet , Jan Peters

In contact-rich tasks, the hybrid, multi-modal nature of contact dynamics poses great challenges in model representation, planning, and control. Recent efforts have attempted to address these challenges via data-driven methods, learning…

Robotics · Computer Science 2024-03-11 Hien Bui , Michael Posa

This paper discusses learning a structured feedback control to obtain sufficient robustness to exogenous inputs for linear dynamic systems with unknown state matrix. The structural constraint on the controller is necessary for many…

Systems and Control · Electrical Eng. & Systems 2021-02-23 Sayak Mukherjee , Thanh Long Vu

The physical design of a robot and the policy that controls its motion are inherently coupled, and should be determined according to the task and environment. In an increasing number of applications, data-driven and learning-based…

Robotics · Computer Science 2018-09-18 Charles Schaff , David Yunis , Ayan Chakrabarti , Matthew R. Walter

Reinforcement learning has shown strong performance in robotic manipulation, but learned policies often degrade in performance when test conditions differ from the training distribution. This limitation is especially important in…

Robotics · Computer Science 2026-04-02 Shaifalee Saxena , Rafael Fierro , Alexander Scheinker

Biological agents learn and act intelligently in spite of a highly limited capacity to process and store information. Many real-world problems involve continuous control, which represents a difficult task for artificial intelligence agents.…

Machine Learning · Computer Science 2025-05-16 Tailia Malloy , Chris R. Sims , Tim Klinger , Miao Liu , Matthew Riemer , Gerald Tesauro

Reinforcement learning (RL) is currently one of the most prominent methods for optimizing dynamical systems, with breakthrough results across various fields. The framework is based on the concept of a Markov decision process (MDP), leading…

Optimization and Control · Mathematics 2025-11-17 Rene Carmona , Mathieu Lauriere

Deciphering the control principles of metabolism and its interaction with other cellular functions is central to biomedicine and biotechnology. Yet, understanding the efficient control of metabolic fluxes remains elusive for large-scale…

Molecular Networks · Quantitative Biology 2015-09-04 Georg Basler , Zoran Nikoloski , Abdelhalim Larhlimi , Albert-László Barabási , Yang-Yu Liu

Reinforcement learning suffers from limitations in real practices primarily due to the number of required interactions with virtual environments. It results in a challenging problem because we are implausible to obtain a local optimal…

Machine Learning · Computer Science 2024-10-28 Qizhen Wu , Kexin Liu , Lei Chen