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Objective: To apply deep learning pose estimation algorithms for vision-based assessment of parkinsonism and levodopa-induced dyskinesia (LID). Methods: Nine participants with Parkinson's disease (PD) and LID completed a levodopa infusion…

Computer Vision and Pattern Recognition · Computer Science 2018-11-12 Michael H. Li , Tiago A. Mestre , Susan H. Fox , Babak Taati

During Deep Brain Stimulation(DBS) surgery for treating Parkinson's disease, one vital task is to detect a specific brain area called the Subthalamic Nucleus(STN) and a sub-territory within the STN called the Dorsolateral Oscillatory…

Signal Processing · Electrical Eng. & Systems 2022-08-24 Ido Cohen , Dan Valsky , Ronen Talmon

In recent years, there are many research cases for the diagnosis of Parkinson's disease (PD) with the brain magnetic resonance imaging (MRI) by utilizing the traditional unsupervised machine learning methods and the supervised deep learning…

Image and Video Processing · Electrical Eng. & Systems 2020-03-11 Xiaobo Zhang , Donghai Zhai , Yan Yang , Yiling Zhang , Chunlin Wang

Early and accurate detection of Parkinson's disease (PD) remains a critical challenge in medical diagnostics due to the subtlety of early-stage symptoms and the complex, non-linear relationships inherent in biomedical data. Traditional…

Machine Learning · Computer Science 2026-02-10 Olamide Samuel Oseni , Ibraheem Omotolani Obanla , Toheeb Aduramomi Jimoh

Growing evidence suggests that phase-locked deep brain stimulation (DBS) can effectively regulate abnormal brain connectivity in neurological and psychiatric disorders. This letter therefore presents a low-power SoC with both neural…

Systems and Control · Electrical Eng. & Systems 2023-03-21 Uisub Shin , Cong Ding , Virginia Woods , Alik S. Widge , Mahsa Shoaran

Diffuse correlation spectroscopy (DCS) analyzes the autocorrelation function of photons scattered by red blood cells, enabling non-invasive, continuous measurement of deep tissue blood flow at the bedside. Multi-layer DCS models (two- and…

Parkinson's Disease (PD) medication management presents unique challenges due to heterogeneous disease progression and treatment response. Neurologists must balance symptom control with optimal dopaminergic dosing based on functional…

Machine Learning · Computer Science 2025-08-15 Ricardo Diaz-Rincon , Muxuan Liang , Adolfo Ramirez-Zamora , Benjamin Shickel

Training Neural Networks (NNs) to behave as Model Predictive Control (MPC) algorithms is an effective way to implement them in constrained embedded devices. By collecting large amounts of input-output data, where inputs represent system…

Systems and Control · Electrical Eng. & Systems 2025-04-16 Alberto Castillo , Elliot Pryor , Anas El Fathi , Boris Kovatchev , Marc Breton

We present a probabilistic programmed deep kernel learning approach to personalized, predictive modeling of neurodegenerative diseases. Our analysis considers a spectrum of neural and symbolic machine learning approaches, which we assess…

Machine Learning · Computer Science 2021-01-13 Alexander Lavin

Parkinson's disease (PD) is a common neurological disorder characterized by gait impairment. PD has no cure, and an impediment to developing a treatment is the lack of any accepted method to predict disease progression rate. The primary aim…

Signal Processing · Electrical Eng. & Systems 2019-11-26 Vyom Raval , Kevin P. Nguyen , Ashley Gerald , Richard B. Dewey , Albert Montillo

This paper presents a model predictive control (MPC) for dynamic systems whose nonlinearity and uncertainty are modelled by deep neural networks (NNs), under input and state constraints. Since the NN output contains a high-order complex…

Systems and Control · Electrical Eng. & Systems 2024-05-20 Jianglin Lan

Parkinson's Disease (PD) is a degenerative neurological disorder that impairs motor and non-motor functions, significantly reducing quality of life and increasing mortality risk. Early and accurate detection of PD progression is vital for…

Machine Learning · Computer Science 2024-12-31 Abhinav Roy , Bhavesh Gyanchandani , Aditya Oza , Abhishek Sharma

Epilepsy affects around 50 million people globally. Electroencephalography (EEG) or Magnetoencephalography (MEG) based spike detection plays a crucial role in diagnosis and treatment. Manual spike identification is time-consuming and…

Machine Learning · Statistics 2026-03-16 Fangyi Wei , Jiajie Mo , Kai Zhang , Haipeng Shen , Srikantan Nagarajan , Fei Jiang

Parkinson's Disease (PD) is a slowly evolving neuro-logical disease that affects about 1% of the population above 60 years old, causing symptoms that are subtle at first, but whose intensity increases as the disease progresses. Automated…

Nonlinear model predictive control (MPC) is a flexible and increasingly popular framework used to synthesize feedback control strategies that can satisfy both state and control input constraints. In this framework, an optimization problem,…

Systems and Control · Electrical Eng. & Systems 2023-05-17 Kong Yao Chee , M. Ani Hsieh , Nikolai Matni

Deadbeat Robust Model Predictive Control (DRMPC) is introduced as a new approach of Robust Model Predictive Control (RMPC) for linear systems with additive disturbances. Its main idea is to completely extinguish the effect of the…

Optimization and Control · Mathematics 2025-10-02 G. Schildbach

Parkinson's disease (PD) is the most widespread movement condition and the second most common neurodegenerative disorder, following Alzheimer's. Movement symptoms and imaging techniques are the most popular ways to diagnose this disease.…

Sound · Computer Science 2024-10-28 Paria Ghaheri , Ahmadreza Shateri , Hamid Nasiri

Bioprocesses are often characterised by nonlinear and uncertain dynamics, posing particular challenges for model predictive control (MPC) algorithms due to their computational demands when applied to nonlinear systems. Recent advances in…

Optimization and Control · Mathematics 2025-02-05 Niels Krausch , Martin Doff-Sotta , Mark Cannon , Peter Neubauer , Mariano Nicolas Cruz Bournazou

Parkinson's disease (PD), the second most prevalent neurodegenerative disorder worldwide, frequently presents with early-stage speech impairments. Recent advancements in Artificial Intelligence (AI), particularly deep learning (DL), have…

Sound · Computer Science 2024-09-25 Lisanne van Gelderen , Cristian Tejedor-García

This paper presents a contact-implicit model predictive control (MPC) framework for the real-time discovery of multi-contact motions, without predefined contact mode sequences or foothold positions. This approach utilizes the…

Robotics · Computer Science 2024-10-03 Gijeong Kim , Dongyun Kang , Joon-Ha Kim , Seungwoo Hong , Hae-Won Park