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We present a method for fast biomedical image atlas construction using neural fields. Atlases are key to biomedical image analysis tasks, yet conventional and deep network estimation methods remain time-intensive. In this preliminary work,…

Image and Video Processing · Electrical Eng. & Systems 2023-11-15 Zeen Chi , Zhongxiao Cong , Clinton J. Wang , Yingcheng Liu , Esra Abaci Turk , P. Ellen Grant , S. Mazdak Abulnaga , Polina Golland , Neel Dey

Developing personalized computational models of the human brain remains a challenge for patient-specific clinical applications and neuroscience research. Efficient and accurate biophysical simulations rely on high-quality personalized…

Computational Engineering, Finance, and Science · Computer Science 2025-03-04 Andy Huynh , Benjamin Zwick , Michael Halle , Adam Wittek , Karol Miller

Atlas construction is fundamental to medical image analysis, offering a standardized spatial reference for tasks such as population-level anatomical modeling. While data-driven registration methods have recently shown promise in pairwise…

Computer Vision and Pattern Recognition · Computer Science 2025-08-15 Ziwei Zou , Bei Zou , Xiaoyan Kui , Wenqi Lu , Haoran Dou , Arezoo Zakeri , Timothy Cootes , Alejandro F Frangi , Jinming Duan

Affine image registration is a cornerstone of medical image analysis. While classical algorithms can achieve excellent accuracy, they solve a time-consuming optimization for every image pair. Deep-learning (DL) methods learn a function that…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Malte Hoffmann , Andrew Hoopes , Douglas N. Greve , Bruce Fischl , Adrian V. Dalca

Deformable templates, or atlases, are images that represent a prototypical anatomy for a population, and are often enhanced with probabilistic anatomical label maps. They are commonly used in medical image analysis for population studies…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Marianne Rakic , Andrew Hoopes , S. Mazdak Abulnaga , Mert R. Sabuncu , John V. Guttag , Adrian V. Dalca

Collecting and annotating morphological data present significant challenges, requiring linguistic expertise, methodological rigour, and substantial resources. These barriers are particularly acute for low-resource languages and varieties.…

Computation and Language · Computer Science 2026-04-07 Aso Mahmudi , Sina Ahmadi , Kemal Kurniawan , Rico Sennrich , Eduard Hovy , Ekaterina Vylomova

Anatomical atlases are widely used for population studies and analysis. Conditional atlases target a specific sub-population defined via certain conditions, such as demographics or pathologies, and allow for the investigation of…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Sophie Starck , Vasiliki Sideri-Lampretsa , Bernhard Kainz , Martin J. Menten , Tamara T. Mueller , Daniel Rueckert

We present a keypoint-based foundation model for general purpose brain MRI registration, based on the recently-proposed KeyMorph framework. Our model, called BrainMorph, serves as a tool that supports multi-modal, pairwise, and scalable…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Alan Q. Wang , Rachit Saluja , Heejong Kim , Xinzi He , Adrian Dalca , Mert R. Sabuncu

Analyzing microscopy images to extract biological object properties (e.g., their morphological organization, temporal dynamics, and population density) is fundamental to various biomedical research. Yet conducting this manually is costly…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Xiaofei Hui , Haoxuan Qu , Hossein Rahmani , Shuohong Wang , Jeff W. Lichtman , Jun Liu

Large scale studies of group differences in healthy controls and patients and screenings for early stage disease prevention programs require processing and analysis of extensive multisubject datasets. Complexity of the task increases even…

Computer Vision and Pattern Recognition · Computer Science 2017-11-02 Alex Fedorov , Eswar Damaraju , Vince Calhoun , Sergey Plis

Building of atlases plays a crucial role in the analysis of brain images. In scenarios where early growth, aging or disease trajectories are of key importance, longitudinal atlases become necessary as references, most often created from…

Image and Video Processing · Electrical Eng. & Systems 2020-03-12 Heejong Kim , Martin Styner , Joseph Piven , Guido Gerig

Early brain development is crucial for lifelong neurodevelopmental health. However, current clinical practice offers limited knowledge of normal embryonic brain anatomy on ultrasound, despite the brain undergoing rapid changes within the…

In this paper, we introduce a novel structural holistic Atlas (holiAtlas) of the human brain anatomy based on multimodal and high-resolution MRI that covers several anatomical levels from the organ to the substructure level, using a new…

A computational anatomy atlas is a set of internal organ geometries. It is based on data of real patients and complemented with virtual cases by using a some numerical approach. Atlases are in demand in computational physiology, especially…

Tissues and Organs · Quantitative Biology 2023-03-21 Konstantin Ushenin , Maksim Dzhigil , Vladislav Dordiuk

Longitudinal fetal brain atlas is a powerful tool for understanding and characterizing the complex process of fetus brain development. Existing fetus brain atlases are typically constructed by averaged brain images on discrete time points…

Image and Video Processing · Electrical Eng. & Systems 2022-09-15 Lixuan Chen , Jiangjie Wu , Qing Wu , Hongjiang Wei , Yuyao Zhang

Within anthropology, the use of three-dimensional (3D) imaging has become increasingly common and widespread since it broadens the available avenues for addressing a wide range of key anthropological issues. The ease with which 3D models…

Computer Vision and Pattern Recognition · Computer Science 2025-01-31 Katrina Yezzi-Woodley , Jeff Calder , Mckenzie Sweno , Chloe Siewert , Peter J. Olver

We present VoxelMorph, a fast learning-based framework for deformable, pairwise medical image registration. Traditional registration methods optimize an objective function for each pair of images, which can be time-consuming for large…

Computer Vision and Pattern Recognition · Computer Science 2019-09-04 Guha Balakrishnan , Amy Zhao , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

Registration-based atlas building often poses computational challenges in high-dimensional image spaces. In this paper, we introduce a novel hybrid atlas building algorithm that fast estimates atlas from large-scale image datasets with much…

Computer Vision and Pattern Recognition · Computer Science 2022-02-15 Nian Wu , Jian Wang , Miaomiao Zhang , Guixu Zhang , Yaxin Peng , Chaomin Shen

Atlas building and image registration are important tasks for medical image analysis. Once one or multiple atlases from an image population have been constructed, commonly (1) images are warped into an atlas space to study intra-subject or…

Image and Video Processing · Electrical Eng. & Systems 2022-04-04 Zhipeng Ding , Marc Niethammer

Biomedical data is inherently multimodal, consisting of electronic health records, medical imaging, digital pathology, genome sequencing, wearable sensors, and more. The application of artificial intelligence tools to these multifaceted…

Machine Learning · Computer Science 2024-08-26 Shentong Mo , Paul Pu Liang
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