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Objective: There are several efforts to re-learn the 2013 ACC/AHA pooled cohort equations (PCE) for patients with specific comorbidities and geographic locations. With over 363 customized risk models in the literature, we aim to evaluate…

Applications · Statistics 2022-09-20 Yizhe Xu , Agata Foryciarz , Ethan Steinberg , Nigam H. Shah

Background: Transitioning from an old medical coding system to a new one can be challenging, especially when the two coding systems are significantly different. The US experienced such a transition in 2015. Objective: This research aims to…

Information Theory · Computer Science 2020-12-24 Jerome Niyirora

Recently, it has been shown that the transition rates of the illness-death model (IDM) for chronic conditions are related to the percentages of people in the states by a three-dimensional system of differential equations [Bri24]. The aim of…

Applications · Statistics 2025-02-05 Ralph Brinks

Many recent studies use machine learning to predict a small number of ICD-9-CM codes. In practice, on the other hand, physicians have to consider a broader range of diagnoses. This study aims to put these previously incongruent evaluation…

Applications · Statistics 2020-06-25 Gil Alon , Elizabeth Chen , Guergana Savova , Carsten Eickhoff

The objective is to assess the extent of variation of data quality and completeness of electronic health records and impact on the robustness of risk predictions of incident cardiovascular disease (CVD) using a risk prediction tool that is…

Applications · Statistics 2019-11-21 Yan Li , Matthew Sperrin , Glen P. Martin , Darren M Ashcroft , Tjeerd Pieter van Staa

Objectives: To examine the distribution, temporal associations, and age/sex-specific patterns of multiple long-term conditions (MLTCs) in adults with intellectual disability (ID). Study Design: Observational study using longitudinal…

Of the 2652 articles considered, 106 met the inclusion criteria. Review of the included papers resulted in identification of 43 chronic diseases, which were then further classified into 10 disease categories using ICD-10. The majority of…

Computers and Society · Computer Science 2019-08-19 Seyedmostafa Sheikhalishahi , Riccardo Miotto , Joel T Dudley , Alberto Lavelli , Fabio Rinaldi , Venet Osmani

Elderly ICU patients with coexisting diabetes mellitus and heart failure experience markedly elevated short-term mortality, yet few predictive models are tailored to this high-risk group. Diabetes mellitus affects nearly 30% of U.S. adults…

Applications · Statistics 2025-06-19 Junyi Fan , Shuheng Chen , Li Sun , Yong Si , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Mapping clinical documents to standardised clinical vocabularies is an important task, as it provides structured data for information retrieval and analysis, which is essential to clinical research, hospital administration and improving…

Computation and Language · Computer Science 2025-09-15 Mingyang Li , Viktor Schlegel , Tingting Mu , Warren Del-Pinto , Goran Nenadic

Coding of unstructured clinical free-text to produce interoperable structured data is essential to improve direct care, support clinical communication and to enable clinical research.However, manual clinical coding is difficult and time…

Cost models in healthcare research must balance interpretability, accuracy, and parameter consistency. However, interpretable models often struggle to achieve both accuracy and consistency. Ordinary least squares (OLS) models for…

Machine Learning · Computer Science 2025-11-10 Chi-Ken Lu , David Alonge , Nicole Richardson , Bruno Richard

Artificial Intelligence has revolutionised critical care for common conditions. Yet, rare conditions in the intensive care unit (ICU), including recognised rare diseases and low-prevalence conditions in the ICU, remain underserved due to…

Machine Learning · Computer Science 2025-07-10 Mingcheng Zhu , Yu Liu , Zhiyao Luo , Tingting Zhu

Comorbidity networks, which capture disease-disease co-occurrence usually based on electronic health records, reveal structured patterns in how diseases cluster and progress across individuals. However, how these networks evolve across…

The infection fatality rate (IFR) of COVID-19 is one of the measures of disease impact that can be of importance for policy making. Here we show that many of the studies on which these estimates are based are scientifically flawed for…

Populations and Evolution · Quantitative Biology 2020-12-24 Chen Shen , Derrick Van Gennep , Alexander F. Siegenfeld , Yaneer Bar-Yam

ICD coding is the international standard for capturing and reporting health conditions and diagnosis for revenue cycle management in healthcare. Manually assigning ICD codes is prone to human error due to the large code vocabulary and the…

Machine Learning · Computer Science 2021-03-16 Youngwoo Kim , Cheng Li , Bingyang Ye , Amir Tahmasebi , Javed Aslam

Automated international classification of diseases (ICD) coding aims to assign multiple disease codes to clinical documents and plays a critical role in healthcare informatics. However, its performance is hindered by the extreme long-tail…

Machine Learning · Computer Science 2026-01-13 Tianlei Chen , Yuxiao Chen , Yang Li , Feifei Wang

Healthcare providers usually record detailed notes of the clinical care delivered to each patient for clinical, research, and billing purposes. Due to the unstructured nature of these narratives, providers employ dedicated staff to assign…

Computation and Language · Computer Science 2022-08-03 Chufan Gao , Mononito Goswami , Jieshi Chen , Artur Dubrawski

In medicine, machine learning (ML) datasets are often built using the International Classification of Diseases (ICD) codes. As new models are being developed, there is a need for larger datasets. However, ICD codes are intended for billing.…

Machine Learning · Computer Science 2024-07-12 Abigail E. Whitlock , Gondy Leroy , Fariba M. Donovan , John N. Galgiani

Clinicians may rely on medical coding systems such as International Classification of Diseases (ICD) to identify patients with diseases from Electronic Health Records (EHRs). However, due to the lack of detail and specificity as well as a…

Computation and Language · Computer Science 2022-05-19 Jingqing Zhang , Atri Sharma , Luis Bolanos , Tong Li , Ashwani Tanwar , Vibhor Gupta , Yike Guo

The use of artificial intelligence in clinical care to improve decision support systems is increasing. This is not surprising since, by its very nature, the practice of medicine consists of making decisions based on observations from…

Quantitative Methods · Quantitative Biology 2019-05-03 Isaac Mativo , Yelena Yesha , Michael Grasso , Tim Oates , Qian Zhu