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High-throughput technologies such as next generation sequencing allow biologists to observe cell function with unprecedented resolution, but the resulting datasets are too large and complicated for humans to understand without the aid of…

Applications · Statistics 2021-10-08 David S. Watson

Artificial Intelligence techniques powered by deep neural nets have achieved much success in several application domains, most significantly and notably in the Computer Vision applications and Natural Language Processing tasks. Surpassing…

Artificial Intelligence · Computer Science 2021-05-19 Gargi Joshi , Rahee Walambe , Ketan Kotecha

In the quest to align deep learning with the sciences to address calls for rigor, safety, and interpretability in machine learning systems, this contribution identifies key missing pieces: the stages of hypothesis formulation and testing,…

Machine Learning · Computer Science 2019-04-25 Jessica Zosa Forde , Michela Paganini

Machine Learning (ML) is one of the most exciting and dynamic areas of modern research and application. The purpose of this review is to provide an introduction to the core concepts and tools of machine learning in a manner easily…

Neural networks have achieved remarkable success across various fields. However, the lack of interpretability limits their practical use, particularly in critical decision-making scenarios. Post-hoc interpretability, which provides…

Machine Learning · Computer Science 2025-11-21 Yang Ji , Ying Sun , Yuting Zhang , Zhigaoyuan Wang , Yuanxin Zhuang , Zheng Gong , Dazhong Shen , Chuan Qin , Hengshu Zhu , Hui Xiong

Deep learning models are widely used for various industrial and scientific applications. Even though these models have achieved considerable success in recent years, there exists a lack of understanding of the rationale behind decisions…

Machine Learning · Computer Science 2020-07-08 Swapnil Nitin Shah

The use of models, even if efficient, must be accompanied by an understanding at all levels of the process that transforms data (upstream and downstream). Thus, needs increase to define the relationships between individual data and the…

Machine Learning · Statistics 2022-09-02 Dimitri Delcaillau , Antoine Ly , Alize Papp , Franck Vermet

Mechanistic interpretability is the program of explaining what AI systems are doing in terms of their internal mechanisms. I analyze some aspects of the program, along with setting out some concrete challenges and assessing progress to…

Artificial Intelligence · Computer Science 2025-01-28 David J. Chalmers

The need for interpretable and accountable intelligent systems grows along with the prevalence of artificial intelligence applications used in everyday life. Explainable intelligent systems are designed to self-explain the reasoning behind…

Human-Computer Interaction · Computer Science 2020-08-06 Sina Mohseni , Niloofar Zarei , Eric D. Ragan

Neural networks organize information according to the hierarchical, multi-scale structure of natural data. Methods to interpret model internals should be similarly scale-aware, explicitly tracking how features compose across resolutions and…

This position paper takes a broad look at Physics-Enhanced Machine Learning (PEML) -- also known as Scientific Machine Learning -- with particular focus to those PEML strategies developed to tackle dynamical systems' challenges. The need to…

Machine Learning · Computer Science 2024-12-30 Alice Cicirello

In healthcare there is a pursuit for employing interpretable algorithms to assist healthcare professionals in several decision scenarios. Following the Predictive, Descriptive and Relevant (PDR) framework, the definition of interpretable…

Neural networks have become increasingly prevalent within the geosciences, although a common limitation of their usage has been a lack of methods to interpret what the networks learn and how they make decisions. As such, neural networks…

Atmospheric and Oceanic Physics · Physics 2020-10-28 Benjamin A. Toms , Elizabeth A. Barnes , Imme Ebert-Uphoff

What is it to interpret the outputs of an opaque machine learning model. One approach is to develop interpretable machine learning techniques. These techniques aim to show how machine learning models function by providing either model…

Machine Learning · Computer Science 2024-09-06 Andrew Smart , Atoosa Kasirzadeh

Achieving complete reproducibility in science, particularly in research fields such as biodiversity, is challenging due to analytical choices, bias and interpretation. Here, we examine examples of reproducibility in biological systematics,…

Other Quantitative Biology · Quantitative Biology 2025-08-01 Charles Morphy D. Santos , Luciana Campos Paulino , Michaella P. Andrade , Gabriel Tognella-Poccia , João Paulo Gois

Most research on the interpretability of machine learning systems focuses on the development of a more rigorous notion of interpretability. I suggest that a better understanding of the deficiencies of the intuitive notion of…

Machine Learning · Statistics 2017-12-08 Fabian Offert

Interpretability aims to explain the behavior of deep neural networks. Despite rapid growth, there is mounting concern that much of this work has not translated into practical impact, raising questions about its relevance and utility. This…

Machine learning has shown much promise in helping improve the quality of medical, legal, and financial decision-making. In these applications, machine learning models must satisfy two important criteria: (i) they must be causal, since the…

Machine Learning · Computer Science 2021-10-12 Carolyn Kim , Osbert Bastani

This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…

Machine Learning · Computer Science 2025-08-25 Ayyüce Begüm Bektaş , Mithat Gönen

Artificial intelligence (AI) is revolutionizing many areas of our lives, leading a new era of technological advancement. Particularly, the transportation sector would benefit from the progress in AI and advance the development of…

Machine Learning · Computer Science 2022-10-19 Yanan Xin , Natasa Tagasovska , Fernando Perez-Cruz , Martin Raubal
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