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We study Crystal Structure Prediction, one of the major problems in computational chemistry. This is essentially a continuous optimization problem, where many different, simple and sophisticated, methods have been proposed and applied. The…

Computational Engineering, Finance, and Science · Computer Science 2020-03-30 Dmytro Antypov , Argyrios Deligkas , Vladimir Gusev , Matthew J. Rosseinsky , Paul G. Spirakis , Michail Theofilatos

Data-driven methods, in particular machine learning, can help to speed up the discovery of new materials by finding hidden patterns in existing data and using them to identify promising candidate materials. In the case of superconductors,…

Superconductivity · Physics 2022-12-15 Timo Sommer , Roland Willa , Jörg Schmalian , Pascal Friederich

Crystal structure prediction algorithms have become powerful tools for materials discovery in recent years, however, they are usually limited to relatively small systems. The main challenge is that the number of local minima grows…

Materials Science · Physics 2022-02-09 Hao Gao , Junjie Wang , Yu Han , Jian Sun

Protein structure prediction has been a grand challenge for over 50 years, owing to its broad scientific and application interests. There are two primary types of modeling algorithms, template-free modeling and template-based modeling. The…

Biological Physics · Physics 2021-06-01 Liangzhen Zheng , Haidong Lan , Tao Shen , Jiaxiang Wu , Sheng Wang , Wei Liu , Junzhou Huang

In this study, we present a novel approach along with the needed computational strategies for efficient and scalable feature engineering of the crystal structure in compounds of different chemical compositions. This approach utilizes a…

Materials Science · Physics 2021-05-25 Prathik R. Kaundinya , Kamal Choudhary , Surya R. Kalidindi

Accurate determination of crystal structures is central to materials science, underpinning the understanding of composition-structure-property relationships and the discovery of new materials. Powder X-ray diffraction is a key technique in…

Materials Science · Physics 2026-03-20 Chenlei Xu , Tianhao Su , Jie Xiong , Yue Wu , Shuya Dong , Tian Jiang , Mengwei He , Shuai Chen , Tong-Yi Zhang

Prediction of protein structures using computational approaches has been explored for over two decades, paving a way for more focused research and development of algorithms in comparative modelling, ab intio modelling and structure…

Quantitative Methods · Quantitative Biology 2020-05-19 Surbhi Dhingra , Ramanathan Sowdhamini , Frédéric Cadet , Bernard Offmann

Accurate crystal structure prediction (CSP) requires accounting for finite-temperature and nuclear quantum effects, yet first-principles evaluation of the free energy surface (FES) remains prohibitive for high-throughput searches. We…

Materials Science · Physics 2026-04-23 Xiaoyang Wang , Yinan Wang , Wenbo Zhao , Hanyu Liu , Hao Xie , Lei Wang , Han Wang

Atomic structure analysis of crystalline materials is a paramount endeavor in both chemical and material sciences. This sophisticated technique necessitates not only a solid foundation in crystallography but also a profound comprehension of…

Machine Learning · Computer Science 2026-04-27 Kaipeng Zheng , Weiran Huang , Wanli Ouyang , Han-Sen Zhong , Yuqiang Li

Crystal structure prediction has been a subject of topical interest, but remains a substantial challenge, especially for complex structures as it deals with the global minimization of the extremely rugged high-dimensional potential energy…

Materials Science · Physics 2022-01-26 Xuecheng Shao , Jian Lv , Peng Liu , Sen Shao , Pengyue Gao , Hanyu Liu , Yanchao Wang , Yanming Ma

One of the long-standing problems in materials science is how to predict a material's structure and then its properties given only its composition. Experimental characterization of crystal structures has been widely used for structure…

Materials Science · Physics 2022-03-29 Rongzhi Dong , Yong Zhao , Yuqi Song , Nihang Fu , Sadman Sadeed Omee , Sourin Dey , Qinyang Li , Lai Wei , Jianjun Hu

We consider the prediction of general tensor properties of crystalline materials, including dielectric, piezoelectric, and elastic tensors. A key challenge here is how to make the predictions satisfy the unique tensor equivariance to O(3)…

Materials Science · Physics 2024-06-21 Keqiang Yan , Alexandra Saxton , Xiaofeng Qian , Xiaoning Qian , Shuiwang Ji

Despite an artificial intelligence-assisted modeling of disordered crystals is a widely used and well-tried method of new materials design, the issues of its robustness, reliability, and stability are still not resolved and even not…

Computational Physics · Physics 2024-11-08 Fedor S. Avilov , Roman A. Eremin , Semen A. Budennyy , Innokentiy S. Humonen

Materials property predictions have improved from advances in machine learning algorithms, delivering materials discoveries and novel insights through data-driven models of structure-property relationships. Nearly all available models rely…

Materials Science · Physics 2022-04-13 Yiqun Wang , Xiao-Jie Zhang , Fei Xia , Elsa A. Olivetti , Ram Seshadri , James M. Rondinelli

A fundamental challenge in materials design is linking building block attributes to crystal structure. Addressing this challenge is particularly difficult for systems that exhibit emergent order, such as entropy-stabilized colloidal…

Materials Science · Physics 2018-01-22 Yina Geng , Greg van Anders , Sharon C. Glotzer

Organic molecular crystals underpin technologies ranging from pharmaceuticals to organic electronics, yet predicting solid-state packing of molecules remains challenging because candidate generation is combinatorial and stability is only…

Understanding and predicting microstructure evolution is fundamental to materials science, as it governs the resulting properties and performance of materials. Traditional simulation methods, such as phase-field models, offer high-fidelity…

Machine Learning · Computer Science 2026-02-24 Michael Trimboli , Mohammed Alsubaie , Sirani M. Perera , Ke-Gang Wang , Xianqi Li

Spatio-temporal prediction plays a crucial role in intelligent transportation, weather forecasting, and urban planning. While integrating multi-modal data has shown potential for enhancing prediction accuracy, key challenges persist: (i)…

Machine Learning · Computer Science 2025-10-29 Yuting Huang , Ziquan Fang , Zhihao Zeng , Lu Chen , Yunjun Gao

Predicting crystal structures from chemical compositions is a fundamental challenge in materials discovery, complicated by complex 3D geometries that distinguish it from fields like protein folding. Here, we present Diffusion-based Crystal…

Crystalline structure prediction is an essential prerequisite for designing materials with targeted properties. Yet, it is still an open challenge in materials design and drug discovery. Despite recent advances in computational materials…

Machine Learning · Computer Science 2025-09-29 Emmanuel Jehanno , Romain Menegaux , Julien Mairal , Sergei Grudinin
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