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Graph Neural Networks (GNNs) have shown strong performance on graph-structured data, but their reliance on graph connectivity often limits scalability and efficiency. Kolmogorov-Arnold Networks (KANs), a recent architecture with learnable…

Machine Learning · Computer Science 2025-08-12 Yuan-Hung Chao , Chia-Hsun Lu , Chih-Ya Shen

Scientific discovery and dynamic characterization of the physical system play a critical role in understanding, learning, and modeling the physical phenomena and behaviors in various fields. Although theories and laws of many system…

Optics · Physics 2025-04-29 Xiaotian Jiang , Min Zhang , Xiao Luo , Zelai Yu , Yiming Meng , Danshi Wang

International initiatives such as METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) have collected several multigenomic and clinical data sets to identify the undergoing molecular processes taking place throughout the…

Machine Learning · Computer Science 2022-11-29 Teodora Reu

This paper explores interpretability techniques for two of the most successful learning algorithms in medical decision-making literature: deep neural networks and random forests. We applied these algorithms in a real-world medical dataset…

Machine Learning · Computer Science 2020-02-24 Catarina Moreira , Renuka Sindhgatta , Chun Ouyang , Peter Bruza , Andreas Wichert

The Kolmogorov-Arnold stochasticity parameter technique is applied for the first time to the study of cancer genome sequencing, to reveal mutations. Using data generated by next generation sequencing technologies, we have analyzed the exome…

Genomics · Quantitative Biology 2018-11-05 V. G. Gurzadyan , H. Yan , G. Vlahovic , A. Kashin , P. Killela , Z. Reitman , S. Sargsyan , G. Yegorian , G. Milledge , B. Vlahovic

Graphs effectively characterize relational data, driving graph representation learning methods that uncover underlying predictive information. As state-of-the-art approaches, Graph Neural Networks (GNNs) enable end-to-end learning for…

Machine Learning · Computer Science 2025-04-24 Mao Wang , Tao Wu , Xingping Xian , Shaojie Qiao , Weina Niu , Canyixing Cui

The 7-point checklist (7PCL) is a widely used diagnostic tool in dermoscopy for identifying malignant melanoma by assigning point values to seven specific attributes. However, the traditional 7PCL is limited to distinguishing between…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Yuheng Wang , Tianze Yu , Jiayue Cai , Sunil Kalia , Harvey Lui , Z. Jane Wang , Tim K. Lee

In anti-cancer drug development, a major scientific challenge is disentangling the complex relationships between high-dimensional genomics data from patient tumor samples, the corresponding tumor's organ of origin, the drug targets…

Machine Learning · Computer Science 2024-03-29 Omid Bazgir , Zichen Wang , Ji Won Park , Marc Hafner , James Lu

The diagnosis and prognosis of cancer are typically based on multi-modal clinical data, including histology images and genomic data, due to the complex pathogenesis and high heterogeneity. Despite the advancements in digital pathology and…

Quantitative Methods · Quantitative Biology 2024-04-15 Zeyu Zhang , Yuanshen Zhao , Jingxian Duan , Yaou Liu , Hairong Zheng , Dong Liang , Zhenyu Zhang , Zhi-Cheng Li

Cancer exhibits diverse and complex phenotypes driven by multifaceted molecular interactions. Recent biomedical research has emphasized the comprehensive study of such diseases by integrating multi-omics datasets (genome, proteome,…

Kolmogorov-Arnold Networks (KANs) relocate learnable nonlinearities from nodes to edges, demonstrating remarkable capabilities in scientific machine learning and interpretable modeling. However, current KAN implementations suffer from…

Neural and Evolutionary Computing · Computer Science 2025-09-25 Alastair Poole , Stig McArthur , Saravan Kumar

Skin cancer is one of the most prevalent and potentially life-threatening diseases worldwide, necessitating early and accurate diagnosis to improve patient outcomes. Conventional diagnostic methods, reliant on clinical expertise and…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Mirza Ahsan Ullah , Tehseen Zia

Cancer survival prediction from multi-omics data remains challenging because prognostic signals are high-dimensional, heterogeneous, and distributed across interacting genes and pathways. We propose PathMoG, a pathway-centric modular graph…

Machine Learning · Computer Science 2026-04-28 Di Wang , Chupei Tang , Junxiao Kong , Jixiu Zhai , Moyu Tang , Tianchi Lu

Clinical decision-making in oncology involves multimodal data such as radiology scans, molecular profiling, histopathology slides, and clinical factors. Despite the importance of these modalities individually, no deep learning framework to…

Computer Vision and Pattern Recognition · Computer Science 2021-07-02 Nathaniel Braman , Jacob W. H. Gordon , Emery T. Goossens , Caleb Willis , Martin C. Stumpe , Jagadish Venkataraman

This paper presents the application of Kolmogorov-Arnold Networks (KAN) in classifying metal surface defects. Specifically, steel surfaces are analyzed to detect defects such as cracks, inclusions, patches, pitted surfaces, and scratches.…

Machine Learning · Computer Science 2025-01-22 Maciej Krzywda , Mariusz Wermiński , Szymon Łukasik , Amir H. Gandomi

The Deep learning (DL) models for diagnosing breast cancer from mammographic images often operate as "black boxes", making it difficult for healthcare professionals to trust and understand their decision-making processes. The study presents…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Maryam Ahmed , Tooba Bibi , Rizwan Ahmed Khan , Sidra Nasir

Brain tumor is the most common and deadliest disease that can be found in all age groups. Generally, MRI modality is adopted for identifying and diagnosing tumors by the radiologists. The correct identification of tumor regions and its type…

Image and Video Processing · Electrical Eng. & Systems 2022-01-10 Sachin Gupta , Narinder Singh Punn , Sanjay Kumar Sonbhadra , Sonali Agarwal

Multimodal knowledge graph link prediction aims to improve the accuracy and efficiency of link prediction tasks for multimodal data. However, for complex multimodal information and sparse training data, it is usually difficult to achieve…

Artificial Intelligence · Computer Science 2023-01-12 Yilin Wen , Biao Luo , Yuqian Zhao

Inspired by the Kolmogorov-Arnold representation theorem and Kurkova's principle of using approximate representations, we propose the Kurkova-Kolmogorov-Arnold Network (KKAN), a new two-block architecture that combines robust multi-layer…

Machine Learning · Computer Science 2024-12-24 Juan Diego Toscano , Li-Lian Wang , George Em Karniadakis

Transformers stand as the cornerstone of mordern deep learning. Traditionally, these models rely on multi-layer perceptron (MLP) layers to mix the information between channels. In this paper, we introduce the Kolmogorov-Arnold Transformer…

Machine Learning · Computer Science 2024-09-18 Xingyi Yang , Xinchao Wang