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Integrative network modeling of data arising from multiple genomic platforms provides insight into the holistic picture of the interactive system, as well as the flow of information across many disease domains including cancer. The basic…

Methodology · Statistics 2020-02-18 Min Jin Ha , Francesco Stingo , Veerabhadran Baladandayuthapani

Cancer is a highly heterogeneous disease with significant variability in molecular features and clinical outcomes, making diagnosis and treatment challenging. In recent years, high-throughput omic technologies have facilitated the discovery…

Quantitative Methods · Quantitative Biology 2024-08-19 Saiful Islam , Md. Nahid Hasan

Deep learning methods have been widely used as an end-to-end modeling strategy of electrical energy systems because of their conveniency and powerful pattern recognition capability. However, due to the "closed-box" nature, deep learning…

Signal Processing · Electrical Eng. & Systems 2026-05-12 Zhenghao Zhou , Yiyan Li , Zelin Guo , Zheng Yan , Mo-Yuen Chow

Convolutional Neural Networks (CNNs) and vision transformers (ViTs) have shown excellent capability in complex hyperspectral image (HSI) classification. However, these models require a significant number of training data and are…

Computer Vision and Pattern Recognition · Computer Science 2024-06-25 Ali Jamali , Swalpa Kumar Roy , Danfeng Hong , Bing Lu , Pedram Ghamisi

Identification of brain regions related to the specific neurological disorders are of great importance for biomarker and diagnostic studies. In this paper, we propose an interpretable Graph Convolutional Network (GCN) framework for the…

Machine Learning · Computer Science 2022-04-29 Houliang Zhou , Lifang He , Yu Zhang , Li Shen , Brian Chen

Personalized cancer treatment is revolutionizing oncology by leveraging precision medicine and advanced computational techniques to tailor therapies to individual patients. Despite its transformative potential, challenges such as limited…

Machine Learning · Computer Science 2025-01-15 Sepinoud Azimi , Louise Spekking , Kateřina Staňková

The morphology of glands has been used routinely by pathologists to assess the malignancy degree of adenocarcinomas. Accurate segmentation of glands from histology images is a crucial step to obtain reliable morphological statistics for…

Computer Vision and Pattern Recognition · Computer Science 2016-04-12 Hao Chen , Xiaojuan Qi , Lequan Yu , Pheng-Ann Heng

Mitotic activity is an important feature for grading several cancer types. Counting mitotic figures (MFs) is a time-consuming, laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incorrect grading and…

Detecting cancers at early stages can dramatically reduce mortality rates. Therefore, practical cancer screening at the population level is needed. Here, we develop a comprehensive detection system to classify all common cancer types. By…

Molecular Networks · Quantitative Biology 2021-03-30 Anyou Wang , Rong Hai , Paul J Rider , Qianchuan He

As key models in geometric deep learning, graph neural networks have demonstrated enormous power in molecular data analysis. Recently, a specially-designed learning scheme, known as Kolmogorov-Arnold Network (KAN), shows unique potential…

Machine Learning · Computer Science 2024-12-19 Longlong Li , Yipeng Zhang , Guanghui Wang , Kelin Xia

Kolmogorov-Arnold Networks (KANs) offer a promising path toward interpretable machine learning: their learnable activations can be studied individually, while collectively fitting complex data accurately. In practice, however, trained…

Machine Learning · Computer Science 2025-12-10 James Bagrow , Josh Bongard

Kolmogorov-Arnold Networks (KANs) are a class of neural networks that have received increased attention in recent literature. In contrast to MLPs, KANs leverage parameterized, trainable activation functions and offer several benefits…

Machine Learning · Computer Science 2025-11-14 Jamison Moody , James Usevitch

Semantic segmentation plays a crucial role in remote sensing applications, where the accurate extraction and representation of features are essential for high-quality results. Despite the widespread use of encoder-decoder architectures,…

Computer Vision and Pattern Recognition · Computer Science 2025-01-14 Xianping Ma , Ziyao Wang , Yin Hu , Xiaokang Zhang , Man-On Pun

The ``black-box'' nature of deep learning models presents a significant barrier to their adoption for scientific discovery, where interpretability is paramount. This challenge is especially pronounced in discovering the governing equations…

Machine Learning · Computer Science 2025-08-26 Riccardo Cappi , Paolo Frazzetto , Nicolò Navarin , Alessandro Sperduti

Kolmogorov-Arnold Networks (KANs) offer a promising alternative to Multi-Layer Perceptron (MLP) by placing learnable univariate functions on network edges, enhancing interpretability. However, standard KANs lack probabilistic outputs,…

Machine Learning · Computer Science 2025-12-02 Y. Sungtaek Ju

Artificial Neural Networks (ANNs) have significantly advanced various fields by effectively recognizing patterns and solving complex problems. Despite these advancements, their interpretability remains a critical challenge, especially in…

Machine Learning · Computer Science 2025-11-24 Alejandro Polo-Molina , David Alfaya , Jose Portela

While deep learning has achieved great success in many fields, one common criticism about deep learning is its lack of interpretability. In most cases, the hidden units in a deep neural network do not have a clear semantic meaning or…

Genomics · Quantitative Biology 2019-06-04 Tianle Ma , Aidong Zhang

The recent development of Kolmogorov-Arnold Networks (KANs) has found its application in the field of Graph Neural Networks (GNNs) particularly in molecular data modeling and potential drug discovery. Kolmogorov-Arnold Graph Neural Networks…

Machine Learning · Computer Science 2026-01-27 Nikita Volzhin , Soowhan Yoon

Kolmogorov-Arnold Networks (KANs) were recently introduced as an alternative representation model to MLP. Herein, we employ KANs to construct physics-informed machine learning models (PIKANs) and deep operator models (DeepOKANs) for solving…

Machine Learning · Computer Science 2024-06-06 Khemraj Shukla , Juan Diego Toscano , Zhicheng Wang , Zongren Zou , George Em Karniadakis

Despite their immense success, deep convolutional neural networks (CNNs) can be difficult to optimize and costly to train due to hundreds of layers within the network depth. Conventional convolutional operations are fundamentally limited by…

Computer Vision and Pattern Recognition · Computer Science 2025-11-07 Ray Congrui Yu , Sherry Wu , Jiang Gui