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Tree-child networks are a recently-described class of directed acyclic graphs that have risen to prominence in phylogenetics (the study of evolutionary trees and networks). Although these networks have a number of attractive mathematical…

Probability · Mathematics 2023-01-10 François Bienvenu , Amaury Lambert , Mike Steel

A phylogenetic network is a graph-theoretical tool that is used by biologists to represent the evolutionary history of a collection of species. One potential way of constructing such networks is via a distance-based approach, where one is…

Combinatorics · Mathematics 2020-06-15 Leo van Iersel , Vincent Moulton , Yukihiro Murakami

The architecture of eukaryotic coding genes allows the production of several different protein isoforms by genes. Current gene phylogeny reconstruction methods make use of a single protein product per gene, ignoring information on…

Data Structures and Algorithms · Computer Science 2017-07-05 Esaie Kuitche , Manuel Lafond , Aïda Ouangraoua

Horizontal gene transfer events partition a gene tree $T$ and thus, its leaf set into subsets of genes whose evolutionary history is described by speciation and duplication events alone. Indirect phylogenetic methods can be used to infer…

Discrete Mathematics · Computer Science 2021-12-02 David Schaller , Marc Hellmuth , Peter F. Stadler

Orthologous genes, which arise through speciation, play a key role in comparative genomics and functional inference. In particular, graph-based methods allow for the inference of orthology estimates without prior knowledge of the underlying…

Populations and Evolution · Quantitative Biology 2025-02-14 Anna Lindeberg , Guillaume E. Scholz , Nicolas Wieseke , Marc Hellmuth

Given any complex directed network, a set of acyclic subgraphs - the hierarchical backbone of the network - can be extracted that will provide valuable information about its hierarchical structure. The current paper presents how the…

Statistical Mechanics · Physics 2007-05-23 Luciano da Fontoura Costa

The inference of phylogenetic networks, which model complex evolutionary processes including hybridization and gene flow, remains a central challenge in evolutionary biology. Until now, statistically consistent inference methods have been…

Populations and Evolution · Quantitative Biology 2025-10-14 Niels Holtgrefe , Elizabeth S. Allman , Hector Baños , Leo van Iersel , Vincent Moulton , John A. Rhodes , Kristina Wicke

When hybridization or other forms of lateral gene transfer have occurred, evolutionary relationships of species are better represented by phylogenetic networks than by trees. While inference of such networks remains challenging, several…

Populations and Evolution · Quantitative Biology 2024-01-15 Elizabeth S. Allman , Hector Baños , Marina Garrote-Lopez , John A. Rhodes

Phylogenetic networks which are, as opposed to trees, suitable to describe processes like hybridization and horizontal gene transfer, play a substantial role in evolutionary research. However, while non-treelike events need to be taken into…

Populations and Evolution · Quantitative Biology 2022-07-06 Mareike Fischer , Tom Niklas Hamann , Kristina Wicke

Research shows that gene duplication followed by either repurposing or removal of duplicated genes is an important contributor to evolution of gene and protein interaction networks. We aim to identify which characteristics of a network can…

Molecular Networks · Quantitative Biology 2021-07-27 Peter Crawford-Kahrl , Robert R. Nerem , Bree Cummins , Tomas Gedeon

Phylogenetic networks are used to study evolutionary relationships between species in biology. Such networks are often categorized into classes by their topological features, which stem from both biological and computational motivations. We…

Combinatorics · Mathematics 2020-04-17 Leo van Iersel , Remie Janssen , Mark Jones , Yukihiro Murakami , Norbert Zeh

Binary trees are fundamental objects in models of evolutionary biology and population genetics. Here, we discuss some of their combinatorial and structural properties as they depend on the tree class considered. Furthermore, the process by…

Populations and Evolution · Quantitative Biology 2021-06-30 Thomas Wiehe

Polyploidization is an evolutionary process by which a species acquires multiple copies of its complete set of chromosomes. The reticulate nature of the signal left behind by it means that phylogenetic networks offer themselves as a…

Populations and Evolution · Quantitative Biology 2023-02-21 Katharina T. Huber , Liam J. Maher

Phylogenetic networks are a generalization of phylogenetic trees that allow for the representation of non-treelike evolutionary events, like recombination, hybridization, or lateral gene transfer. In a recent series of papers devoted to the…

Populations and Evolution · Quantitative Biology 2007-07-17 Gabriel Cardona , Francesc Rossello , Gabriel Valiente

A contemporary and fundamental problem faced by many evolutionary biologists is how to puzzle together a collection $\mathcal P$ of partial trees (leaf-labelled trees whose leaves are bijectively labelled by species or, more generally,…

Combinatorics · Mathematics 2007-09-04 S. Grünewald , K. T. Huber , Q. Wu

Phylogenetic trees and networks are leaf-labelled graphs used to model evolution. Display graphs are created by identifying common leaf labels in two or more phylogenetic trees or networks. The treewidth of such graphs is bounded as a…

Data Structures and Algorithms · Computer Science 2018-09-05 Remie Janssen , Mark Jones , Steven Kelk , Georgios Stamoulis , Taoyang Wu

An important and well-studied problem in phylogenetics is to compute a \emph{consensus tree} so as to summarize the common features within a collection of rooted phylogenetic trees, all whose leaf-sets are bijectively labeled by the same…

Populations and Evolution · Quantitative Biology 2021-07-22 Katharina T. Huber , Vincent Moulton , Andreas Spillner

Genomes and genes diversify during evolution; however, it is unclear to what extent genes still retain the relationship among species. Model species for molecular phylogenetic studies include yeasts and viruses whose genomes were sequenced…

Genomics · Quantitative Biology 2008-06-09 Yunfeng Shan , Xiu-Qing Li

Reconstructing the evolutionary past of a family of genes is an important aspect of many genomic studies. To help with this, simple operations on a set of sequences called orthology relations may be employed. In addition to being…

Discrete Mathematics · Computer Science 2016-03-16 K. T. Huber , G. E. Scholz

Methods that generate networks sharing a given degree distribution and global clustering can induce changes in structural properties other than that controlled for. Diversity in structural properties, in turn, can affect the outcomes of…

Social and Information Networks · Computer Science 2018-09-18 Peter Overbury , István Z. Kiss , Luc Berthouze