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Knowledge Graph Completion has been increasingly adopted as a useful method for helping address several tasks in biomedical research, such as drug repurposing or drug-target identification. To that end, a variety of datasets and Knowledge…

Machine Learning · Computer Science 2025-11-07 Alberto Cattaneo , Stephen Bonner , Thomas Martynec , Edward Morrissey , Carlo Luschi , Ian P Barrett , Daniel Justus

We present the extention and application of a new unsupervised statistical learning technique--the Partition Decoupling Method--to gene expression data. Because it has the ability to reveal non-linear and non-convex geometries present in…

Quantitative Methods · Quantitative Biology 2015-09-24 Rosemary Braun , Gregory Leibon , Scott Pauls , Daniel Rockmore

Learning distributions of graphs can be used for automatic drug discovery, molecular design, complex network analysis, and much more. We present an improved framework for learning generative models of graphs based on the idea of deep state…

Machine Learning · Computer Science 2021-12-07 Julian Stier , Michael Granitzer

Machine learning on graph structured data has attracted much research interest due to its ubiquity in real world data. However, how to efficiently represent graph data in a general way is still an open problem. Traditional methods use…

Machine Learning · Computer Science 2019-11-14 Jiaqi Ma , Qiaozhu Mei

Many inference tasks on knowledge graphs, including relation prediction, operate on knowledge graph embeddings -- vector representations of the vertices (entities) and edges (relations) that preserve task-relevant structure encoded within…

Artificial Intelligence · Computer Science 2026-01-19 John Cobb , Thomas Gebhart

Multi-domain recommender systems benefit from cross-domain representation learning and positive knowledge transfer. Both can be achieved by introducing a specific modeling of input data (i.e. disjoint history) or trying dedicated training…

Information Retrieval · Computer Science 2023-02-23 Alejandro Ariza-Casabona , Bartlomiej Twardowski , Tri Kurniawan Wijaya

Machine learning strategies like multi-task learning, meta-learning, and transfer learning enable efficient adaptation of machine learning models to specific applications in healthcare, such as prediction of various diseases, by leveraging…

Machine Learning · Computer Science 2024-12-31 Sophie Wharrie , Lisa Eick , Lotta Mäkinen , Andrea Ganna , Samuel Kaski , FinnGen

Machine Learning methods have of late made significant efforts to solving multidisciplinary problems in the field of cancer classification using microarray gene expression data. Feature subset selection methods can play an important role in…

Computational Engineering, Finance, and Science · Computer Science 2013-03-04 G. Prat , Ll. Belanche

Accurate prediction of cancer progression remains a challenge due to the high heterogeneity of molecular omics data across patients. While biologically informed models have improved the interpretability of these predictions, a persistent…

Machine Learning · Computer Science 2026-04-21 Koushik Howlader , Md Tauhidul Islam , Wei Le

Recent studies show that deep learning models achieve good performance on medical imaging tasks such as diagnosis prediction. Among the models, multimodality has been an emerging trend, integrating different forms of data such as chest…

Machine Learning · Computer Science 2022-02-10 Haodi Zhang , Chenyu Xu , Peirou Liang , Ke Duan , Hao Ren , Weibin Cheng , Kaishun Wu

Multimodal movie genre classification has always been regarded as a demanding multi-label classification task due to the diversity of multimodal data such as posters, plot summaries, trailers and metadata. Although existing works have made…

Artificial Intelligence · Computer Science 2023-10-13 Jiaqi Li , Guilin Qi , Chuanyi Zhang , Yongrui Chen , Yiming Tan , Chenlong Xia , Ye Tian

In medical fields, text classification is one of the most important tasks that can significantly reduce human workload through structured information digitization and intelligent decision support. Despite the popularity of learning-based…

Computation and Language · Computer Science 2020-12-15 J Liu , R Bai , Z Lu , P Ge , D Liu , Uwe Aickelin

Genomic signal processing has been used successfully in bioinformatics to analyze biomolecular sequences and gain varied insights into DNA structure, gene organization, protein binding, sequence evolution, etc. But challenges remain in…

Genomics · Quantitative Biology 2022-11-04 Saish Jaiswal , Shreya Nema , Hema A Murthy , Manikandan Narayanan

Identification of causal genes and pathways is a critical step for understanding the genetic underpinnings of rare diseases. We propose novel approaches to gene prioritization and pathway identification using DNA language model, graph…

Quantitative Methods · Quantitative Biology 2024-11-12 Ali Saadat , Jacques Fellay

In recent years, there has been a resurgence in methods that use distributed (neural) representations to represent and reason about semantic knowledge for robotics applications. However, while robots often observe previously unknown…

Robotics · Computer Science 2021-05-11 Angel Daruna , Mehul Gupta , Mohan Sridharan , Sonia Chernova

Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue…

Computation and Language · Computer Science 2020-12-23 Shuai Lin , Pan Zhou , Xiaodan Liang , Jianheng Tang , Ruihui Zhao , Ziliang Chen , Liang Lin

Recently, it has become progressively more evident that classic diagnostic labels are unable to reliably describe the complexity and variability of several clinical phenotypes. This is particularly true for a broad range of neuropsychiatric…

Machine Learning · Computer Science 2024-02-28 Giovanna Maria Dimitri , Simeon Spasov , Andrea Duggento , Luca Passamonti , Pietro Li`o , Nicola Toschi

Expert diagnostic support systems have been extensively studied. The practical applications of these systems in real-world scenarios have been somewhat limited due to well-understood shortcomings, such as lack of extensibility. More…

Artificial Intelligence · Computer Science 2018-08-15 Murali Ravuri , Anitha Kannan , Geoffrey J. Tso , Xavier Amatriain

Graphs are a powerful tool for representing and analyzing unstructured, non-Euclidean data ubiquitous in the healthcare domain. Two prominent examples are molecule property prediction and brain connectome analysis. Importantly, recent works…

Machine Learning · Computer Science 2022-04-04 Kamilia Mullakaeva , Luca Cosmo , Anees Kazi , Seyed-Ahmad Ahmadi , Nassir Navab , Michael M. Bronstein

In computational biology, gene expression datasets are characterized by very few individual samples compared to a large number of measurements per sample. Thus, it is appealing to merge these datasets in order to increase the number of…

Methodology · Statistics 2011-08-18 Meili Baragatti