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Heterogeneous molecular entities and their interactions, commonly depicted as a network, are crucial for advancing our systems-level understanding of biology. With recent advancements in high-throughput data generation and a significant…

Quantitative Methods · Quantitative Biology 2026-03-18 Kishan KC , Rui Li , Paribesh Regmi , Anne R. Haake

Hypergraphs generalize classical graphs by allowing a single edge to connect multiple vertices, providing a natural language for modeling higher-order interactions. Superhypergraphs extend this paradigm further by accommodating nested,…

Artificial Intelligence · Computer Science 2026-03-03 Takaaki Fujita , Florentin Smarandache

Hypergraphs model higher-order relations that drive real-world decisions, from drug prescriptions to recommendations. A central structural signal in such data, beyond what pairwise relations can express, is interaction compositionality:…

Machine Learning · Computer Science 2026-05-19 Kyrie Zhao , Zehong Wang , Tianyi Ma , Fang Wu , Xiangru Tang , Pietro Lio , Sheng Wang , Yanfang Ye

Networks are important structures used to model complex systems where interactions take place. In a basic network model, entities are represented as nodes, and interaction and relations among them are represented as edges. However, in a…

Social and Information Networks · Computer Science 2021-02-18 Mehmet Emin Aktas , Esra Akbas

The irreducible complexity of natural phenomena has led Graph Neural Networks to be employed as a standard model to perform representation learning tasks on graph-structured data. While their capacity to capture local and global patterns is…

Machine Learning · Computer Science 2024-02-13 Lorenzo Giusti

Hypergraphs play a pivotal role in the modelling of data featuring higher-order relations involving more than two entities. Hypergraph neural networks emerge as a powerful tool for processing hypergraph-structured data, delivering…

Machine Learning · Computer Science 2024-06-04 Zexi Liu , Bohan Tang , Ziyuan Ye , Xiaowen Dong , Siheng Chen , Yanfeng Wang

Dynamic graph learning (DGL) aims to learn informative and temporally-evolving node embeddings to support downstream tasks such as link prediction. A fundamental challenge in DGL lies in effectively modeling both the temporal dynamics and…

Social and Information Networks · Computer Science 2025-06-10 Ling Wang

Hypergraph neural networks (HGNN) have recently become attractive and received significant attention due to their excellent performance in various domains. However, most existing HGNNs rely on first-order approximations of hypergraph…

Artificial Intelligence · Computer Science 2024-01-11 Maolin Wang , Yaoming Zhen , Yu Pan , Yao Zhao , Chenyi Zhuang , Zenglin Xu , Ruocheng Guo , Xiangyu Zhao

Modeling temporal multimodal data poses significant challenges in classification tasks, particularly in capturing long-range temporal dependencies and intricate cross-modal interactions. Audiovisual data, as a representative example, is…

Machine Learning · Computer Science 2025-08-05 Feng Xu , Hui Wang , Yuting Huang , Danwei Zhang , Zizhu Fan

Graph Neural Networks (GNN) have gained significant traction in the forecasting domain, especially for their capacity to simultaneously account for intra-series temporal correlations and inter-series relationships. This paper introduces a…

Machine Learning · Computer Science 2024-05-30 Abishek Sriramulu , Nicolas Fourrier , Christoph Bergmeir

Complex systems, such as economic, social, biological, and ecological systems, usually feature interactions not only between pairwise entities but also among three or more entities. These multi-entity interactions are known as higher-order…

Physics and Society · Physics 2025-06-06 Junhap Bian , Tao Zhou , Yilin Bi

Mining Electronic Health Records (EHRs) becomes a promising topic because of the rich information they contain. By learning from EHRs, machine learning models can be built to help human experts to make medical decisions and thus improve…

Machine Learning · Computer Science 2021-01-19 Zheng Liu , Xiaohan Li , Hao Peng , Lifang He , Philip S. Yu

Sequence classification has a wide range of real-world applications in different domains, such as genome classification in health and anomaly detection in business. However, the lack of explicit features in sequence data makes it difficult…

Machine Learning · Computer Science 2023-06-19 Khaled Mohammed Saifuddin , Corey May , Farhan Tanvir , Muhammad Ifte Khairul Islam , Esra Akbas

Reaction virtual screening and discovery are fundamental challenges in chemistry and materials science, where traditional graph neural networks (GNNs) struggle to model multi-reactant interactions. In this work, we propose ChemHGNN, a…

Machine Learning · Computer Science 2025-06-16 Xiaobao Huang , Yihong Ma , Anjali Gurajapu , Jules Schleinitz , Zhichun Guo , Sarah E. Reisman , Nitesh V. Chawla

Psychiatric disorders have been traditionally conceptualized as latent conditions producing observable symptoms, but recent studies suggest that psychopathology may emerge from symptoms interactions. Psychometric networking model these…

Social and Information Networks · Computer Science 2026-04-27 Francesca Possenti , Laura Girelli , Paolo Tieri , Manuela Petti

The importance of higher-order relations is widely recognized in a large number of real-world systems. However, annotating them is a tedious and sometimes impossible task. Consequently, current approaches for data modelling either ignore…

Machine Learning · Computer Science 2025-06-06 Iulia Duta , Pietro Liò

Higher order interactions are increasingly recognised as a fundamental aspect of complex systems ranging from the brain to social contact networks. Hypergraph as well as simplicial complexes capture the higher-order interactions of complex…

Physics and Society · Physics 2021-09-23 Hanlin Sun , Ginestra Bianconi

Complex systems are often driven by higher-order interactions among multiple units, naturally represented as hypergraphs. Understanding dependency structures within these hypergraphs is crucial for understanding and predicting the behavior…

Social and Information Networks · Computer Science 2025-05-29 John Hood , Caterina De Bacco , Aaron Schein

Hypergraphs, capable of representing high-order interactions via hyperedges, have become a powerful tool for modeling real-world biological and social systems. Inherent relationships within these real-world systems, such as the encoding…

Social and Information Networks · Computer Science 2025-05-09 Li Ni , Ziqi Deng , Lin Mu , Lei Zhang , Wenjian Luo , Yiwen Zhang

Understanding human mobility is essential for applications ranging from urban planning to public health. Traditional mobility models such as flow networks and colocation matrices capture only pairwise interactions between discrete…

Social and Information Networks · Computer Science 2025-03-25 Prathyush Sambaturu , Bernardo Gutierrez , Moritz U. G. Kraemer