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While Artificial Neural Networks (ANNs) have yielded impressive results in the realm of simulated intelligent behavior, it is important to remember that they are but sparse approximations of Biological Neural Networks (BNNs). We go beyond…

Neural and Evolutionary Computing · Computer Science 2021-03-30 Krishna Katyal , Jesse Parent , Bradly Alicea

Recent advances in spatial omics technologies have revolutionized our ability to study biological systems with unprecedented resolution. By preserving the spatial context of molecular measurements, these methods enable comprehensive mapping…

Quantitative Methods · Quantitative Biology 2025-09-18 Zhiwei Fan , Tiangang Wang , Kexin Huang , Binwu Ying , Xiaobo Zhou

Present day computers expend orders of magnitude more computational resources to perform various cognitive and perception related tasks that humans routinely perform everyday. This has recently resulted in a seismic shift in the field of…

Emerging Technologies · Computer Science 2017-12-22 Abhronil Sengupta , Kaushik Roy

Tumor organoid-on-a-chip platforms represent a cutting-edge fusion of patient-derived organoids with microfluidic technologies, offering unprecedented capabilities for personalized cancer research. These systems overcome limitations of…

Tissues and Organs · Quantitative Biology 2025-07-30 Keyvan Alavi

Abstract: Bionic learning with fused sensing, memory and processing functions outperforms artificial neural networks running on silicon chips in terms of efficiency and footprint. However, digital hardware implementation of bionic learning…

Emerging Technologies · Computer Science 2022-02-22 Shijie Wang , Xi Chen , Chao Zhao , Yuxin Kong , Baojun Lin , Yongyi Wu , Zhaozhao Bi , Ziyi Xuan , Tao Li , Yuxiang Li , Wei Zhang , En Ma , Zhongrui Wang , Wei Ma

Computing in the life sciences has undergone a transformative evolution, from early computational models in the 1950s to the applications of artificial intelligence (AI) and machine learning (ML) seen today. This paper highlights key…

Other Quantitative Biology · Quantitative Biology 2024-06-21 Samuel A. Donkor , Matthew E. Walsh , Alexander J. Titus

Computer simulations have become a very powerful tool for scientific research. Given the vast complexity that comes with many open scientific questions, a purely analytical or experimental approach is often not viable. For example,…

Neural and Evolutionary Computing · Computer Science 2016-07-12 Roman Bauer , Lukas Breitwieser , Alberto Di Meglio , Leonard Johard , Marcus Kaiser , Marco Manca , Manuel Mazzara , Max Talanov

The intricate nature of the brain necessitates the application of advanced probing techniques to comprehensively study and understand its working mechanisms. Neurophotonics offers minimally invasive methods to probe the brain using optics…

For complex life to evolve, a sophisticated nervous system for handling its complexities was fundamental. The demand resulted in the emergence of brain's computational facility, the neuronal network. This facet of the brain is attested…

Neurons and Cognition · Quantitative Biology 2019-09-16 Jahan N. Schad

Recently, stemming from the rapid development of artificial intelligence, which has gained expansive success in pattern recognition, robotics, and bioinformatics, neuroscience is also gaining tremendous progress. A kind of spiking neural…

Neural and Evolutionary Computing · Computer Science 2024-07-02 Shengjie Zheng , Lang Qian , Pingsheng Li , Chenggang He , Xiaoqin Qin , Xiaojian Li

Neuroimaging has profoundly enhanced our understanding of the human brain by characterizing its structure, function, and connectivity through modalities like MRI, fMRI, EEG, and PET. These technologies have enabled major breakthroughs…

Applications · Statistics 2026-02-16 Jian Kang , Thomas Nichols , Lexin Li , Martin A. Lindquist , Hongtu Zhu

Advances in bioinformatics are primarily due to new algorithms for processing diverse biological data sources. While sophisticated alignment algorithms have been pivotal in analyzing biological sequences, deep learning has substantially…

This paper proposes a specific conceptualization of intelligence as computation. This conceptualization is intended to provide a unified view for all disciplines of intelligence research. Already, it unifies several conceptualizations…

Artificial Intelligence · Computer Science 2024-05-28 Oliver Brock

We present a novel method for quantifying the microscopic structure of brain tissue. It is based on the automated recognition of interpretable features obtained by analyzing the shapes of cells. This contrasts with prevailing methods of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-10 Kui Qian , Litao Qiao , Beth Friedman , Edward O'Donnell , David Kleinfeld , Yoav Freund

As neural computation is revolutionizing the field of Artificial Intelligence (AI), rethinking the ideal neural hardware is becoming the next frontier. Fast and reliable von Neumann architecture has been the hosting platform for neural…

Neural and Evolutionary Computing · Computer Science 2024-12-31 Yigit Demirag

Genetic algorithms, computer programs that simulate natural evolution, are increasingly applied across many disciplines. They have been used to solve various optimisation problems from neural network architecture search to strategic games,…

Neural and Evolutionary Computing · Computer Science 2021-09-14 Aymeric Vie , Alissa M. Kleinnijenhuis , Doyne J. Farmer

Human routines structure daily life, yet remain challenging for computational systems to understand. This paper presents the first systematic review of routine computing, a previously implicit but increasingly recognized field that focuses…

Human-Computer Interaction · Computer Science 2026-04-27 Borislav Pavlov , Jiajin Li , Jun Fang , Yuntao Wang , Yuanchun Shi

Artificial General Intelligence (AGI) has been a long-standing goal of humanity, with the aim of creating machines capable of performing any intellectual task that humans can do. To achieve this, AGI researchers draw inspiration from the…

Artificial Intelligence · Computer Science 2023-03-29 Lin Zhao , Lu Zhang , Zihao Wu , Yuzhong Chen , Haixing Dai , Xiaowei Yu , Zhengliang Liu , Tuo Zhang , Xintao Hu , Xi Jiang , Xiang Li , Dajiang Zhu , Dinggang Shen , Tianming Liu

The field of machine learning has focused, primarily, on discretized sub-problems (i.e. vision, speech, natural language) of intelligence. While neuroscience tends to be observation heavy, providing few guiding theories. It is unlikely that…

Artificial Intelligence · Computer Science 2020-03-11 Jordan Ott

Brain-computer interfaces (BCIs) are enabling a range of new possibilities and routes for augmenting human capability. Here, we propose BCIs as a route towards forms of computation, i.e. computational imaging, that blend the brain with…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Gao Wang , Daniele Faccio