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Digital Breast Tomosynthesis is an X-ray imaging technique that allows a volumetric reconstruction of the breast, from a small number of low-dose two-dimensional projections. Although it is already used in clinical setting, enhancing the…

Numerical Analysis · Mathematics 2020-07-21 Elena Morotti , Elena Loli Piccolomini

Previous work showed that total variation superiorization (TVS) improves reconstructed image quality in proton computed tomography (pCT). The structure of the TVS algorithm has evolved since then and this work investigated if this new…

Medical Physics · Physics 2019-01-18 Blake Schultze , Yair Censor , Paniz Karbasi , Keith E. Schubert , Reinhard W. Schulte

The Centers for Medicare & Medicaid Services (CMS) has introduced CMS1074v2, a quality measure for computed tomography (CT) that assesses radiation dose and image quality across 18 CT exam categories. This measure mandates the calculation…

Medical Physics · Physics 2025-03-11 Gary Y Ge , Charles M Weaver , Jie Zhang

Background: Manual delineation of target volumes in head and neck cancer (HNC) remains a significant bottleneck in radiotherapy planning, characterized by high inter-observer variability and time consumption. This study evaluates the…

Breast cancer is the most commonly diagnosed cancer in women and a leading cause of cancer death worldwide. Screening mammography reduces mortality, yet interpretation still suffers from substantial false negatives and false positives, and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Charles Fanning , Mehmet Emin Aktas

Speed-of-sound has been shown as a potential biomarker for breast cancer imaging, successfully differentiating malignant tumors from benign ones. Speed-of-sound images can be reconstructed from time-of-flight measurements from ultrasound…

Image and Video Processing · Electrical Eng. & Systems 2020-07-23 Melanie Bernhardt , Valery Vishnevskiy , Richard Rau , Orcun Goksel

Ultrasound computed tomography (USCT) holds great promise for improving the detection and management of breast cancer. Because they are based on the acoustic wave equation, waveform inversion-based reconstruction methods can produce images…

Medical Physics · Physics 2015-01-05 Kun Wang , Thomas Matthews , Fatima Anis , Cuiping Li , Neb Duric , Mark A. Anastasio

Breast cancer is the most frequently diagnosed human cancer in the United States at present. Early detection is crucial for its successful treatment. X-ray mammography and digital breast tomosynthesis are currently the main methods for…

Objective: Quantify geometric and dosimetric accuracy of a novel prostate MR-to-MR deformable image registration (DIR) approach to support MR-guided adaptive radiation therapy dose accumulation. Approach: We evaluated DIR accuracy in 25…

Computed Tomography (CT) measures the attenuation coefficient of an object and converts the value assigned to each voxel into a CT number. In radiation therapy, CT number, which is directly proportional to the linear attenuation…

Medical Physics · Physics 2015-03-13 Dong Joo Rhee , Sung-woo Kim , Young Min Moon , Jung Ki Kim , Dong Hyeok Jeong

In this paper, we would like to quantitatively measure the tumor volume contained in the breast imaged by the Digital Breast Tomosynthesis (DBT), a reconstructed 3D image. The estimated volume will add to the prognostic value of risk…

Medical Physics · Physics 2018-04-17 Bocar Wane

Digital Breast Tomosynthesis (DBT) is a widely used medical imaging modality for breast cancer screening and diagnosis, offering higher spatial resolution and greater detail through its 3D-like breast volume imaging capability. However, the…

Image and Video Processing · Electrical Eng. & Systems 2024-03-21 Yuexi Du , Regina J. Hooley , John Lewin , Nicha C. Dvornek

Differentiation of breast tissues is challenging in X-ray imaging because tissues might share similar or even the same linear attenuation coefficients $\mu$. Spectral computed tomography (CT) allows for more quantitative characterization in…

Ultrasound tomography (UST) scanners allow quantitative images of the human breast's acoustic properties to be derived with potential applications in screening, diagnosis and therapy planning. Time domain full waveform inversion (TD-FWI) is…

Numerical Analysis · Mathematics 2022-01-19 Felix Lucka , Mailyn Pérez-Liva , Bradley E. Treeby , Ben T. Cox

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a minimally invasive imaging technique which can be used for characterizing tumor biology and tumor response to radiotherapy. Pharmacokinetic (PK) estimation is widely used…

Image and Video Processing · Electrical Eng. & Systems 2018-03-06 Xia Zhu , Dipanjan Sengupta , Andrew Beers , Kalpathy-Cramer Jayashree , Theodore L. Willke

Adaptive Radiotherapy (ART) is an emerging technique for treating cancer patients which facilitates higher delivery accuracy and has the potential to reduce toxicity. However, ART is also resource-intensive, requiring extra human and…

Medical Physics · Physics 2022-12-20 Rupesh Ghimire , Kevin L. Moore , Daniela Branco , Dominique L. Rash , Jyoti Mayadev , Xenia Ray

Purpose: The goal of this study was to assess the potential added benefit of accounting for partial volume effects (PVE) in an automatic coronary lumen segmentation algorithm from coronary computed tomography angiography (CCTA). Materials…

Image and Video Processing · Electrical Eng. & Systems 2019-06-25 Moti Freiman , Hannes Nickisch , Sven Prevrhal , Holger Schmitt , Mani Vembar , Pál Maurovich-Horvat , Patrick Donnelly , Liran Goshen

High radiation dose in CT scans increases a lifetime risk of cancer and has become a major clinical concern. Recently, iterative reconstruction algorithms with Total Variation (TV) regularization have been developed to reconstruct CT images…

Medical Physics · Physics 2015-05-19 Zhen Tian , Xun Jia , Kehong Yuan , Tinsu Pan , Steve B. Jiang

Summary mean DCE-MRI variables show a clear dependency between signal and noise variance, which can be shown to reduce the effectiveness of difference assessments. Appropriate transformation of these variables supports statistically…

Medical Physics · Physics 2023-03-20 S. V. Notley , N. A. Thacker , L. Horsley , R. A. Little , Y. Watson , S. Mullamitha , G. C. Jayson , A. Jackson

Purpose. - Radiotherapy is an important treatment for prostate cancer.During treatment sessions, bladder and rectal repletion is difficult to quantify and cannot be measured with a single and initial CT scan acquisition. Some methods, such…

Medical Physics · Physics 2011-04-06 Cyril Voyant , Katia Biffi , Leschi Delphine , Jerome Briancon , Celine Lantieri Marcovici