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Multimodal pathological images are usually in clinical diagnosis, but computer vision-based multimodal image-assisted diagnosis faces challenges with modality fusion, especially in the absence of expert-annotated data. To achieve the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Qinghua Lin , Guang-Hai Liu , Zuoyong Li , Yang Li , Yuting Jiang , Xiang Wu

Prediction tasks in digital pathology are challenging due to the massive size of whole-slide images (WSIs) and the weak nature of training signals. Advances in computing, data availability, and self-supervised learning (SSL) have paved the…

Image and Video Processing · Electrical Eng. & Systems 2026-02-02 Vishwesh Ramanathan , Tony Xu , Pushpak Pati , Faruk Ahmed , Maged Goubran , Anne L. Martel

The use of diverse modalities, such as omics, medical images, and clinical data can not only improve the performance of prognostic models but also deepen an understanding of disease mechanisms and facilitate the development of novel…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Maria Boyko , Aleksandra Beliaeva , Dmitriy Kornilov , Alexander Bernstein , Maxim Sharaev

Multimodal deep learning has shown strong potential in medical applications by integrating heterogeneous data sources such as medical images and structured clinical variables. However, most existing approaches implicitly assume complete…

Machine Learning · Computer Science 2026-05-13 Camillo Maria Caruso , Valerio Guarrasi , Paolo Soda

Medical decision systems increasingly rely on data from multiple sources to ensure reliable and unbiased diagnosis. However, existing multimodal learning models fail to achieve this goal because they often ignore two critical challenges.…

Machine Learning · Computer Science 2025-10-10 Md Zubair , Hao Zheng , Nussdorf Jonathan , Grayson W. Armstrong , Lucy Q. Shen , Gabriela Wilson , Yu Tian , Xingquan Zhu , Min Shi

Many problems in science and engineering require making predictions based on few observations. To build a robust predictive model, these sparse data may need to be augmented with simulated data, especially when the design space is…

Accurate prognosis of non-small cell lung cancer (NSCLC) patients undergoing immunotherapy is essential for personalized treatment planning, enabling informed patient decisions, and improving both treatment outcomes and quality of life.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-22 Qilong Xing , Zikai Song , Bingxin Gong , Lian Yang , Junqing Yu , Wei Yang

Imbalanced datasets pose a considerable challenge in training deep learning (DL) models for medical diagnostics, particularly for segmentation tasks. Imbalance may be associated with annotation quality limited annotated datasets, rare…

Image and Video Processing · Electrical Eng. & Systems 2025-04-08 Bashir Alam , Masa Cirkovic , Mete Harun Akcay , Md Kaf Shahrier , Sebastien Lafond , Hergys Rexha , Kurt Benke , Sepinoud Azimi , Janan Arslan

A key challenge in learning from multimodal biological data is missing modalities, where data from one or more modalities are absent for some patients. Existing approaches either exclude patients with missing modalities, impute missing…

Machine Learning · Computer Science 2026-05-19 Sina Tabakhi , Chen , Chen , Haiping Lu

Framing the investigation of diverse cancers as a machine learning problem has recently shown significant potential in multi-omics analysis and cancer research. Empowering these successful machine learning models are the high-quality…

Genomics · Quantitative Biology 2025-06-17 Ziwei Yang , Rikuto Kotoge , Xihao Piao , Zheng Chen , Lingwei Zhu , Peng Gao , Yasuko Matsubara , Yasushi Sakurai , Jimeng Sun

The acquisition of different data modalities can enhance our knowledge and understanding of various diseases, paving the way for a more personalized healthcare. Thus, medicine is progressively moving towards the generation of massive…

Image and Video Processing · Electrical Eng. & Systems 2024-05-06 Tiago Mota , M. Rita Verdelho , Alceu Bissoto , Carlos Santiago , Catarina Barata

The potential benefits of applying machine learning methods to -omics data are becoming increasingly apparent, especially in clinical settings. However, the unique characteristics of these data are not always well suited to machine learning…

Multi-disease diagnosis using multi-modal data like electronic health records and medical imaging is a critical clinical task. Although existing deep learning methods have achieved initial success in this area, a significant gap persists…

Multimedia · Computer Science 2025-09-22 Yueheng Jiang , Peng Zhang

Biomedical data is inherently multimodal, consisting of electronic health records, medical imaging, digital pathology, genome sequencing, wearable sensors, and more. The application of artificial intelligence tools to these multifaceted…

Machine Learning · Computer Science 2024-08-26 Shentong Mo , Paul Pu Liang

Multi-modality cardiac imaging plays a key role in the management of patients with cardiovascular diseases. It allows a combination of complementary anatomical, morphological and functional information, increases diagnosis accuracy, and…

Image and Video Processing · Electrical Eng. & Systems 2022-08-30 Lei Li , Wangbin Ding , Liqun Huang , Xiahai Zhuang , Vicente Grau

Preparing high-quality datasets required by various data-driven AI and machine learning models has become a cornerstone task in data-driven analysis. Conventional data discovery methods typically integrate datasets towards a single…

Databases · Computer Science 2025-03-18 Mengying Wang , Hanchao Ma , Yiyang Bian , Yangxin Fan , Yinghui Wu

The integration of multi-omics data has emerged as a promising approach for gaining comprehensive insights into complex diseases such as cancer. This paper proposes a novel approach to identify cancer subtypes through the integration of…

Machine Learning · Computer Science 2023-12-06 Mark Peelen , Leila Bagheriye , Johan Kwisthout

The rapidly emerging field of deep learning-based computational pathology has shown promising results in utilizing whole slide images (WSIs) to objectively prognosticate cancer patients. However, most prognostic methods are currently…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Mingxin Liu , Yunzan Liu , Hui Cui , Chunquan Li , Jiquan Ma

Cancer has relational information residing at varying scales, modalities, and resolutions of the acquired data, such as radiology, pathology, genomics, proteomics, and clinical records. Integrating diverse data types can improve the…

Machine Learning · Computer Science 2024-07-29 Asim Waqas , Aakash Tripathi , Ravi P. Ramachandran , Paul Stewart , Ghulam Rasool

Cross-modal alignment aims to map heterogeneous modalities into a shared latent space, as exemplified by models like CLIP, which benefit from large-scale image-text pretraining for strong recognition capabilities. However, when operating in…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Jiaxiang Liu , Yuan Wang , Jiawei Du , Joey Tianyi Zhou , Mingkun Xu , Zuozhu Liu