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Background and objective: Cell-level pathological image analysis requires working with extremely small image patches (40x40 pixels), far below standard ImageNet resolutions. It remains unclear whether modern deep learning architectures and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Hiroki Kagiyama , Toru Nagasaka , Yukari Adachi , Takaaki Tachibana , Ryota Ito , Mitsugu Fujita , Kimihiro Yamashita , Yoshihiro Kakeji

Foundation models have revolutionized the paradigm of digital pathology, as they leverage general-purpose features to emulate real-world pathological practices, enabling the quantitative analysis of critical histological patterns and the…

Curating, processing, and combining large-scale medical imaging datasets from national studies is a non-trivial task due to the intense computation and data throughput required, variability of acquired data, and associated financial…

Medical vision foundation models remain limited in downstream tasks, particularly volumetric medical image segmentation. While fine-tuning on labeled target-domain data improves performance, existing approaches typically rely on randomly…

Image and Video Processing · Electrical Eng. & Systems 2026-05-07 Jin Yang , Daniel S. Marcus , Aristeidis Sotiras

Foundation models pretrained on large-scale pathology datasets have shown promising results across various diagnostic tasks. Here, we present a systematic evaluation of transfer learning strategies for brain tumor classification using these…

Image and Video Processing · Electrical Eng. & Systems 2025-04-09 Ken Enda , Yoshitaka Oda , Zen-ichi Tanei , Kenichi Satoh , Hiroaki Motegi , Terasaka Shunsuke , Shigeru Yamaguchi , Takahiro Ogawa , Wang Lei , Masumi Tsuda , Shinya Tanaka

The main focus of image mining in the proposed method is concerned with the classification of brain tumor in the CT scan brain images. The major steps involved in the system are: pre-processing, feature extraction, association rule mining…

Computer Vision and Pattern Recognition · Computer Science 2010-03-25 P. Rajendran , M. Madheswaran

Despite the promise of computational pathology foundation models, adapting them to specific clinical tasks remains challenging due to the complexity of whole-slide image (WSI) processing, the opacity of learned features, and the wide range…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Abdul Rahman Diab , Emily E. Karn , Renchin Wu , Emily S. Ruiz , William Lotter

Data-centric artificial intelligence (AI) has remarkably advanced medical imaging, with emerging methods using synthetic data to address data scarcity while introducing synthetic-to-real gaps. Unsupervised domain adaptation (UDA) shows…

Image and Video Processing · Electrical Eng. & Systems 2025-09-03 Linyu Fan , Che Wang , Ming Ye , Qizhi Yang , Zejun Wu , Xinghao Ding , Yue Huang , Jianfeng Bao , Shuhui Cai , Congbo Cai

Multiple instance learning (MIL) has become a preferred method for gigapixel whole slide image (WSI) classification without requiring patch-level annotations. Current MIL research primarily relies on embedding-based approaches, which…

Computer Vision and Pattern Recognition · Computer Science 2025-03-10 Bryan Wong , Sungrae Hong , Mun Yong Yi

Large-scale cell microscopy screens are used in drug discovery and molecular biology research to study the effects of millions of chemical and genetic perturbations on cells. To use these images in downstream analysis, we need models that…

Foundation models (FMs) are catalyzing a transformative shift in materials science (MatSci) by enabling scalable, general-purpose, and multimodal AI systems for scientific discovery. Unlike traditional machine learning models, which are…

Machine Learning · Computer Science 2025-06-27 Minh-Hao Van , Prateek Verma , Chen Zhao , Xintao Wu

Pathology foundation models (PFMs) have become central to computational pathology, aiming to offer general encoders for feature extraction from whole-slide images (WSIs). Despite strong benchmark performance, PFM robustness to real-world…

Image and Video Processing · Electrical Eng. & Systems 2026-01-08 Erik Thiringer , Fredrik K. Gustafsson , Kajsa Ledesma Eriksson , Mattias Rantalainen

With the rapid development of self-supervised learning (e.g., contrastive learning), the importance of having large-scale images (even without annotations) for training a more generalizable AI model has been widely recognized in medical…

Automatic integration of whole slide images (WSIs) and gene expression profiles has demonstrated substantial potential in precision clinical diagnosis and cancer progression studies. However, most existing studies focus on individual gene…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Junzhuo Liu , Xuemei Du , Daniel Reisenbuchler , Ye Chen , Markus Eckstein , Christian Matek , Friedrich Feuerhake , Dorit Merhof

Medical image segmentation is crucial for disease diagnosis and treatment planning, yet developing robust segmentation models often requires substantial computational resources and large datasets. Existing research shows that pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Paul Zaha , Lars Böcking , Simeon Allmendinger , Leopold Müller , Niklas Kühl

Large medical image data sets with high dimensionality require substantial amount of computation time for data creation and data processing. This paper presents a novel generalized method that finds optimal image-based feature sets that…

Computer Vision and Pattern Recognition · Computer Science 2016-10-25 Sohini Roychowdhury

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang

This paper introduces an innovative software system for fundus image analysis that deliberately diverges from the conventional screening approach, opting not to predict specific diagnoses. Instead, our methodology mimics the diagnostic…

Computer Vision and Pattern Recognition · Computer Science 2025-01-27 Dmitry Ryabtsev , Boris Vasilyev , Sergey Shershakov

Federated learning and its application to medical image segmentation have recently become a popular research topic. This training paradigm suffers from statistical heterogeneity between participating institutions' local datasets, incurring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-19 Matthis Manthe , Stefan Duffner , Carole Lartizien

Large Multimodal Models (LMMs), or Vision-Language Models (VLMs), have shown impressive capabilities in a wide range of visual tasks. However, they often struggle with fine-grained visual reasoning, failing to identify domain-specific…

Computer Vision and Pattern Recognition · Computer Science 2025-02-26 Yucheng Shi , Quanzheng Li , Jin Sun , Xiang Li , Ninghao Liu