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Decomposing model activations into interpretable components is a key open problem in mechanistic interpretability. Sparse autoencoders (SAEs) are a popular method for decomposing the internal activations of trained transformers into sparse,…

Machine Learning · Computer Science 2024-06-26 Connor Kissane , Robert Krzyzanowski , Joseph Isaac Bloom , Arthur Conmy , Neel Nanda

Genome sequencing projects are rapidly increasing the number of high-dimensional protein sequence datasets. Clustering a high-dimensional protein sequence dataset using traditional machine learning approaches poses many challenges. Many…

Quantitative Methods · Quantitative Biology 2022-04-27 Preeti Jha , Aruna Tiwari , Neha Bharill , Milind Ratnaparkhe , Om Prakash Patel , Nilagiri Harshith , Mukkamalla Mounika , Neha Nagendra

Being able to interpret, or explain, the predictions made by a machine learning model is of fundamental importance. This is especially true when there is interest in deploying data-driven models to make high-stakes decisions, e.g. in…

Machine Learning · Computer Science 2019-10-01 An-phi Nguyen , María Rodríguez Martínez

We introduce sparse autoencoder neural operators (SAE-NOs), a new class of sparse autoencoders that operate in function spaces rather than fixed-dimensional Euclidean representations. We formalize the functional representation hypothesis,…

Machine Learning · Computer Science 2026-05-11 Bahareh Tolooshams , Ailsa Shen , Anima Anandkumar

Unsupervised learning of high-dimensional data is challenging due to irrelevant or noisy features obscuring underlying structures. It's common that only a few features, called the influential features, meaningfully define the clusters.…

Machine Learning · Computer Science 2026-03-26 Chen Ma , Wanjie Wang , Shuhao Fan

Sparse Autoencoders (SAEs) are widely used to interpret neural networks by identifying meaningful concepts from their representations. However, do SAEs truly uncover all concepts a model relies on, or are they inherently biased toward…

Machine Learning · Computer Science 2025-12-03 Sai Sumedh R. Hindupur , Ekdeep Singh Lubana , Thomas Fel , Demba Ba

Sparse methods are the standard approach to obtain interpretable models with high prediction accuracy. Alternatively, algorithmic ensemble methods can achieve higher prediction accuracy at the cost of loss of interpretability. However, the…

Methodology · Statistics 2022-01-11 Anthony Christidis , Stefan Van Aelst , Ruben Zamar

Statistical learning methods are widely utilized in tackling complex problems due to their flexibility, good predictive performance and its ability to capture complex relationships among variables. Additionally, recently developed automatic…

Methodology · Statistics 2023-11-14 Natalia da Silva , Ignacio Alvarez-Castro , Leonardo Moreno , Andrés Sosa

Sparse autoencoders (SAEs) have been applied to large language models and protein language models, but not systematically to electronic health record (EHR) foundation models. We train TopK SAEs on FlatASCEND, a 14.5-million-parameter…

Machine Learning · Computer Science 2026-05-07 Chris Sainsbury , Feng Dong , Andreas Karwath

Principal component analysis (PCA) is an exploratory tool widely used in data analysis to uncover dominant patterns of variability within a population. Despite its ability to represent a data set in a low-dimensional space, the…

Sparse autoencoders (SAEs) are now standard tools for decomposing language model activations into interpretable features, and automated interpretability pipelines routinely assign each feature a short natural-language explanation. Existing…

Machine Learning · Computer Science 2026-05-14 Jordan F. McCann

Sparse Autoencoders (SAEs) have shown to find interpretable features in neural networks from polysemantic neurons caused by superposition. Previous work has shown SAEs are an effective tool to extract interpretable features from the early…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Matthew Bozoukov

Interpretability and stability are two important features that are desired in many contemporary big data applications arising in economics and finance. While the former is enjoyed to some extent by many existing forecasting approaches, the…

Statistics Theory · Mathematics 2018-09-14 Yingying Fan , Jinchi Lv , Mahrad Sharifvaghefi , Yoshimasa Uematsu

Extreme neural network sparsification (90% activation reduction) presents a critical challenge for mechanistic interpretability: understanding whether interpretable features survive aggressive compression. This work investigates feature…

Machine Learning · Computer Science 2026-04-10 Dip Roy , Rajiv Misra , Sanjay Kumar Singh

Real-world problems are often dependent on multiple data modalities, making multimodal fusion essential for leveraging diverse information sources. In high-stakes domains, such as in healthcare, understanding how each modality contributes…

Neural and Evolutionary Computing · Computer Science 2025-05-19 Mafalda Malafaia , Thalea Schlender , Tanja Alderliesten , Peter A. N. Bosman

Sparse auto-encoders (SAEs) have re-emerged as a prominent method for mechanistic interpretability, yet they face two significant challenges: the non-smoothness of the $L_1$ penalty, which hinders reconstruction and scalability, and a lack…

Artificial Intelligence · Computer Science 2026-05-19 Ouns El Harzli , Hugo Wallner , Yoonsoo Nam , Haixuan Xavier Tao

The current catalyst discovery and development pipeline for energy-intensive applications like methane conversion remains bottlenecked by expensive trial-and-error experimentation, irreproducible chemical intuition, and a lack of frameworks…

Chemical Physics · Physics 2026-05-12 Oyinkansola Romiluyi

Prototypical part learning is emerging as a promising approach for making semantic segmentation interpretable. The model selects real patches seen during training as prototypes and constructs the dense prediction map based on the similarity…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Hugo Porta , Emanuele Dalsasso , Diego Marcos , Devis Tuia

The lack of interpretability and transparency are preventing economists from using advanced tools like neural networks in their empirical research. In this paper, we propose a class of interpretable neural network models that can achieve…

Econometrics · Economics 2020-12-01 Yucheng Yang , Zhong Zheng , Weinan E

Speculative decoding accelerates autoregressive inference by drafting candidate tokens with a fast model and verifying them in parallel with the target. Self-speculative methods avoid the need for an external drafter but have been studied…

Computation and Language · Computer Science 2026-05-05 Hector Borobia , Elies Seguí-Mas , Guillermina Tormo-Carbó