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Topological Data Analysis (TDA) can be used to detect and characterize holes in an image, such as zero-dimensional holes (connected components) or one-dimensional holes (loops). However, there is currently no widely accepted statistical…

Methodology · Statistics 2025-08-26 Susan Glenn , Jessi Cisewski-Kehe , Jun Zhu , William M Bement

Glomerulosclerosis, interstitial fibrosis, and tubular atrophy (IFTA) are histologic indicators of irrecoverable kidney injury. In standard clinical practice, the renal pathologist visually assesses, under the microscope, the percentage of…

Tissues and Organs · Quantitative Biology 2021-06-23 Brandon Ginley , Kuang-Yu Jen , Avi Rosenberg , Felicia Yen , Sanjay Jain , Agnes Fogo , Pinaki Sarder

Modern business and economic datasets often exhibit nonlinear, multi-scale structures that traditional linear tools under-represent. Topological Data Analysis (TDA) offers a geometric lens for uncovering robust patterns, such as connected…

Machine Learning · Statistics 2025-11-18 Ioannis Diamantis

Topological data analysis (TDA) is a rising branch in modern applied mathematics. It extracts topological structures as features of a given space and uses these features to analyze digital data. Persistent homology, one of the central tools…

Algebraic Topology · Mathematics 2025-05-26 Chuan-Shen Hu

We present a nonparametric Bayesian method for disease subtype discovery in multi-dimensional cancer data. Our method can simultaneously analyse a wide range of data types, allowing for both agreement and disagreement between their…

Genomics · Quantitative Biology 2013-04-16 Richard S. Savage , Zoubin Ghahramani , Jim E. Griffin , Paul Kirk , David L. Wild

Gland segmentation is a critical step to quantitatively assess the morphology of glands in histopathology image analysis. However, it is challenging to separate densely clustered glands accurately. Existing deep learning-based approaches…

Image and Video Processing · Electrical Eng. & Systems 2021-10-28 Haotian Wang , Min Xian , Aleksandar Vakanski

Topological Data Analysis (TDA) has been praised by researchers for its ability to capture intricate shapes and structures within data. TDA is considered robust in handling noisy and high-dimensional datasets, and its interpretability is…

Machine Learning · Computer Science 2024-01-10 Funmilola Mary Taiwo , Umar Islambekov , Cuneyt Gurcan Akcora

Understanding the behavior and evolution of a dynamical many-body system by analyzing patterns in their experimentally captured images is a promising method relevant for a variety of living and non-living self-assembled systems. The arrays…

This survey provides a comprehensive exploration of applications of Topological Data Analysis (TDA) within neural network analysis. Using TDA tools such as persistent homology and Mapper, we delve into the intricate structures and behaviors…

Machine Learning · Computer Science 2024-01-04 Rubén Ballester , Carles Casacuberta , Sergio Escalera

Despite significant advances in the field of deep learning in ap-plications to various areas, an explanation of the learning pro-cess of neural network models remains an important open ques-tion. The purpose of this paper is a comprehensive…

Machine Learning · Computer Science 2023-06-07 German Magai

A fundamental challenge in diagnostic imaging is the phenomenon of topological equivalence, where benign and malignant structures share global topology but differ in critical geometric detail, leading to diagnostic errors in both…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Mariem Abaach , Ian Morilla

We perform topological data analysis on the internal states of convolutional deep neural networks to develop an understanding of the computations that they perform. We apply this understanding to modify the computations so as to (a) speed…

Machine Learning · Computer Science 2018-11-06 Gunnar Carlsson , Rickard Brüel Gabrielsson

Computed tomography imaging is a standard modality for detecting and assessing lung cancer. In order to evaluate the malignancy of lung nodules, clinical practice often involves expert qualitative ratings on several criteria describing a…

Computer Vision and Pattern Recognition · Computer Science 2016-09-22 Mario Buty , Ziyue Xu , Mingchen Gao , Ulas Bagci , Aaron Wu , Daniel J. Mollura

Topological data analysis (TDA), as a relatively recent approach, has demonstrated great potential in capturing the intrinsic and robust structural features of complex data. While persistent homology, as a core tool of TDA, focuses on…

Combinatorics · Mathematics 2025-11-11 Jing-Wen Gao , Yunan He , Jian Liu

Topological methods can provide a way of proposing new metrics and methods of scrutinising data, that otherwise may be overlooked. In this work, a method of quantifying the shape of data, via a topic called topological data analysis will be…

Machine Learning · Statistics 2022-09-25 Tristan Gowdridge , Nikolaos Dervilis , Keith Worden

We present a short tutorial and introduction to using the R package TDA, which provides some tools for Topological Data Analysis. In particular, it includes implementations of functions that, given some data, provide topological information…

Mathematical Software · Computer Science 2015-01-30 Brittany Terese Fasy , Jisu Kim , Fabrizio Lecci , Clément Maria

Glioma, the prevalent primary brain tumor, exhibits diverse aggressiveness levels and prognoses. Precise classification of glioma is paramount for treatment planning and predicting prognosis. This study aims to develop an algorithm to fuse…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Kiranmayee Janardhan , Christy Bobby Thomas

The surge of data available on the Internet has driven the adoption of a wide range of computational methods for analyzing and extracting insights from large-scale data. Among these, Machine Learning (ML) has become a central paradigm,…

Computation and Language · Computer Science 2026-05-12 Adaku Uchendu , Thai Le

Combinatorial and topological structures, such as graphs, simplicial complexes, and cell complexes, form the foundation of geometric and topological deep learning (GDL and TDL) architectures. These models aggregate signals over such…

Machine Learning · Computer Science 2026-05-28 Chuan-Shen Hu

Alterations in nuclear morphology are useful adjuncts and even diagnostic tools used by pathologists in the diagnosis and grading of many tumors, particularly malignant tumors. Large datasets such as TCGA and the Human Protein Atlas, in…

Quantitative Methods · Quantitative Biology 2023-02-06 Mohammad Shifat E Rabbi , Natasha Ironside , John A Ozolek , Rajendra Singh , Liron Pantanowitz , Gustavo K Rohde