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This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…
Interpretability is critical for machine learning models in high-stakes settings because it allows users to verify the model's reasoning. In computer vision, prototypical part models (ProtoPNets) have become the dominant model type to meet…
Deep learning models have had a great success in disease classifications using large data pools of skin cancer images or lung X-rays. However, data scarcity has been the roadblock of applying deep learning models directly on prostate…
In supervised learning for medical image analysis, sample selection methodologies are fundamental to attain optimum system performance promptly and with minimal expert interactions (e.g. label querying in an active learning setup). In this…
Oral cancer presents a formidable challenge in oncology, necessitating early diagnosis and accurate prognosis to enhance patient survival rates. Recent advancements in machine learning and data mining have revolutionized traditional…
Recent advancements in artificial intelligence (AI) have facilitated its widespread adoption in primary medical services, addressing the demand-supply imbalance in healthcare. Vision Transformers (ViT) have emerged as state-of-the-art…
Current machine learning models are evaluated through behavioral snapshots, with benchmark accuracies, win rates and outcome-based metrics. Model explanations and evaluations, however, are fundamentally intertwined: understanding why a…
Recent advances in machine learning for medical imaging have led to impressive increases in model complexity and overall capabilities. However, the ability to discern the precise information a machine learning method is using to make…
Melanoma is a prevalent lethal type of cancer that is treatable if diagnosed at early stages of development. Skin lesions are a typical indicator for diagnosing melanoma but they often led to delayed diagnosis due to high similarities of…
With the increasing availability of patient data, modern medicine is shifting towards prospective healthcare. Electronic health records offer a variety of information useful for clinical patient characterization and the development of…
We examine the optical properties of a system of nano and micro particles of varying size, shape, and material (including metals and dielectrics, and sub-wavelength and super-wavelength regimes). Training data is generated by numerically…
Conventional machine learning methods are predominantly designed to predict outcomes based on a single data type. However, practical applications may encompass data of diverse types, such as text, images, and audio. We introduce…
Public and nonprofit organizations often hesitate to adopt AI tools because most models are opaque even though standard approaches typically analyze aggregate patterns rather than offering actionable, case-level guidance. This study tests a…
Time-to-event prediction, e.g. cancer survival analysis or hospital length of stay, is a highly prominent machine learning task in medical and healthcare applications. However, only a few interpretable machine learning methods comply with…
In cancer therapeutics, protein-metal binding mechanisms critically govern the pharmacokinetics and targeting efficacy of drugs, thereby fundamentally shaping the rational design of anticancer metallodrugs. While conventional laboratory…
Optimal treatment rules can improve health outcomes on average by assigning a treatment associated with the most desirable outcome to each individual. Due to an unknown data generation mechanism, it is appealing to use flexible models to…
Deep learning (DL) models have been popular due to their ability to learn directly from the raw data in an end-to-end paradigm, alleviating the concern of a separate error-prone feature extraction phase. Recent DL-based neuroimaging studies…
Clinical decisions are high-stakes and require explicit justification, making model interpretability essential for auditing deep clinical models prior to deployment. As the ecosystem of model architectures and explainability methods…
One of the key challenges when developing a predictive model is the capability to describe the domain knowledge and the cause-effect relationships in a simple way. Decision rules are a useful and important methodology in this context,…
The last decade has seen huge progress in the development of advanced machine learning models; however, those models are powerless unless human users can interpret them. Here we show how the mind's construction of concepts and meaning can…