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The increasing availability of geometric data has motivated the need for information processing over non-Euclidean domains modeled as manifolds. The building block for information processing architectures with desirable theoretical…

Signal Processing · Electrical Eng. & Systems 2022-11-22 Zhiyang Wang , Luana Ruiz , Alejandro Ribeiro

One of the major challenges in biology concerns the integration of data across length and time scales into a consistent framework: how do macroscopic properties and functionalities arise from the molecular regulatory networks - and how can…

Computational Engineering, Finance, and Science · Computer Science 2015-10-20 Dagmar Iber , Zahra Karimaddini , Erkan Ünal

A topology optimization approach for designing large deformation contact-aided shape morphing compliant mechanisms is presented. Such mechanisms can be used in varying operating conditions. Design domains are described by regular hexagonal…

Computational Engineering, Finance, and Science · Computer Science 2020-10-23 Prabhat Kumar , Roger A. Sauer , Anupam Saxena

Hidden convexity is a powerful idea in optimization: under the right transformations, nonconvex problems that are seemingly intractable can be solved efficiently using convex optimization. We introduce the notion of a Lagrangian dual…

Optimization and Control · Mathematics 2025-11-07 Venkat Chandrasekaran , Timothy Duff , Jose Israel Rodriguez , Kevin Shu

Structural optimization (topology, shapes, sizing) is an important tool for facilitating the emergence of new concepts in structural design. Normally, topology optimization is carried out at the early stage of design and then shape and…

Optimization and Control · Mathematics 2021-03-16 Ghislain Raze , Joseph Morlier

We present a new framework for the simultaneous optimiziation of both the topology as well as the relative density grading of cellular structures and materials, also known as lattices. Due to manufacturing constraints, the optimization…

Computational Engineering, Finance, and Science · Computer Science 2025-05-27 Jonathan Stollberg , Tarun Gangwar , Oliver Weeger , Dominik Schillinger

End-to-end optimization, which simultaneously optimizes optics and algorithms, has emerged as a powerful data-driven method for computational imaging system design. This method achieves joint optimization through backpropagation by…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Chi-Jui Ho , Yash Belhe , Steve Rotenberg , Ravi Ramamoorthi , Tzu-Mao Li , Nicholas Antipa

Emergence is a phenomenon taken for granted in science but also still not well understood. We have developed a model of artificial genetic evolution intended to allow for emergence on genetic, population and social levels. We present the…

Populations and Evolution · Quantitative Biology 2015-05-19 Chris Marriott , Jobran Chebib

Topology optimization is used for the design of high-performance structures but remains fundamentally limited by its iterative nature, requiring repeated finite element analyses that prevent real-time deployment and large-scale design…

Computational Engineering, Finance, and Science · Computer Science 2026-04-07 Aaron Lutheran , Srijan Das , Alireza Tabarraei

Recent decades have seen the discovery of numerous complex materials. At the root of the complexity underlying many of these materials lies a large number of possible contending atomic- and larger-scale configurations and the intricate…

Materials Science · Physics 2023-01-30 P. Ronhovde , S. Chakrabarty , M. Sahu , K. K. Sahu , K. F. Kelton , N. Mauro , Z. Nussinov

Unraveling the structural factors influencing the dynamics of amorphous solids is crucial. While deep learning aids in navigating these complexities, transparency issues persist. Inspired by the successful application of prototype neural…

Soft Condensed Matter · Physics 2024-03-19 Xiao Jiang , Zean Tian , Kenli Li , Wangyu Hu

Despite their potential to address crucial bottlenecks in computing architectures and contribute to the pool of biological inspiration for engineering, pathological biological mechanisms remain absent from computational theory. We hereby…

Neural and Evolutionary Computing · Computer Science 2025-03-18 Rosalia Moreddu , Michael Levin

Conventional electronics is founded on a paradigm where shaping perfect electrical elements is done at the fabrication plant, so as to make devices and systems identical, "eternally immutable". In nature, morphogenic evolutions are observed…

Since its foundations, more than one hundred years ago, the field of structural biology has strived to understand and analyze the properties of molecules and their interactions by studying the structure that they take in 3D space. However,…

Biomolecules · Quantitative Biology 2023-02-27 Gabriele Corso

Topology Optimization seeks to find the best design that satisfies a set of constraints while maximizing system performance. Traditional iterative optimization methods like SIMP can be computationally expensive and get stuck in local…

Machine Learning · Computer Science 2023-03-20 Giorgio Giannone , Faez Ahmed

Understanding how cells respond to external stimuli is a central challenge in biomedical research and drug development. Current computational frameworks for modelling cellular responses remain restricted to two-dimensional representations,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Reed Naidoo , Matt De Vries , Olga Fourkioti , Vicky Bousgouni , Mar Arias-Garcia , Maria Portillo-Malumbres , Chris Bakal

Delineation of curvilinear structures is an important problem in Computer Vision with multiple practical applications. With the advent of Deep Learning, many current approaches on automatic delineation have focused on finding more powerful…

Computer Vision and Pattern Recognition · Computer Science 2017-12-07 Agata Mosinska , Pablo Marquez-Neila , Mateusz Kozinski , Pascal Fua

The evolution of computer architecture has led to a paradigm shift from traditional single-core processors to multi-core and domain-specific architectures that address the increasing demands of modern computational workloads. This paper…

Partial Differential Equations are infinite dimensional encoded representations of physical processes. However, imbibing multiple observation data towards a coupled representation presents significant challenges. We present a fully…

Machine Learning · Computer Science 2020-03-09 Gurpreet Singh , Soumyajit Gupta , Matt Lease , Clint N. Dawson

The increasing demands of sustainable energy, electronics, and biomedical applications call for next-generation functional materials with unprecedented properties. Of particular interest are emerging materials that display exceptional…