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Natural language processing (NLP) is a key technology to extract important patient information from clinical narratives to support healthcare applications. The rapid development of large language models (LLMs) has revolutionized many NLP…

Computation and Language · Computer Science 2025-09-08 Cheng Peng , Xinyu Dong , Mengxian Lyu , Daniel Paredes , Yaoyun Zhang , Yonghui Wu

We consider the protein sequence engineering problem, which aims to find protein sequences with high fitness levels, starting from a given wild-type sequence. Directed evolution has been a dominating paradigm in this field which has an…

Machine Learning · Computer Science 2025-01-20 Yinkai Wang , Jiaxing He , Yuanqi Du , Xiaohui Chen , Jianan Canal Li , Li-Ping Liu , Xiaolin Xu , Soha Hassoun

Emerging topics in biomedical research are continuously expanding, providing a wealth of information about genes and their function. This rapid proliferation of knowledge presents unprecedented opportunities for scientific discovery and…

Genomics · Quantitative Biology 2024-12-25 Zhijian Chen , Chuan Hu , Min Wu , Qingqing Long , Xuezhi Wang , Yuanchun Zhou , Meng Xiao

Large Language Models (LLMs) have gained widespread popularity due to their ability to perform ad-hoc Natural Language Processing (NLP) tasks with a simple natural language prompt. Part of the appeal for LLMs is their approachability to the…

Human-Computer Interaction · Computer Science 2025-02-25 Aditi Mishra , Utkarsh Soni , Anjana Arunkumar , Jinbin Huang , Bum Chul Kwon , Chris Bryan

This project investigates the efficacy of Large Language Models (LLMs) in understanding and extracting scientific knowledge across specific domains and to create a deep learning framework: Knowledge AI. As a part of this framework, we…

Computation and Language · Computer Science 2024-08-12 Balaji Muralidharan , Hayden Beadles , Reza Marzban , Kalyan Sashank Mupparaju

The advent of immersive Virtual Reality applications has transformed various domains, yet their integration with advanced artificial intelligence technologies like Visual Language Models remains underexplored. This study introduces a…

Robotics · Computer Science 2024-08-06 Mikhail Konenkov , Artem Lykov , Daria Trinitatova , Dzmitry Tsetserukou

Predicting molecular properties is a critical component of drug discovery. Recent advances in deep learning, particularly Graph Neural Networks (GNNs), have enabled end-to-end learning from molecular structures, reducing reliance on manual…

Computation and Language · Computer Science 2025-09-26 Peng Zhou , Lai Hou Tim , Zhixiang Cheng , Kun Xie , Chaoyi Li , Wei Liu , Xiangxiang Zeng

Natural Language Processing (NLP) is an essential subset of artificial intelligence. It has become effective in several domains, such as healthcare, finance, and media, to identify perceptions, opinions, and misuse, among others. Privacy is…

Computation and Language · Computer Science 2025-01-20 Andrick Adhikari , Sanchari Das , Rinku Dewri

We introduce VLM-Lens, a toolkit designed to enable systematic benchmarking, analysis, and interpretation of vision-language models (VLMs) by supporting the extraction of intermediate outputs from any layer during the forward pass of…

Computation and Language · Computer Science 2025-10-03 Hala Sheta , Eric Huang , Shuyu Wu , Ilia Alenabi , Jiajun Hong , Ryker Lin , Ruoxi Ning , Daniel Wei , Jialin Yang , Jiawei Zhou , Ziqiao Ma , Freda Shi

Protein language models (PLMs) have emerged as powerful tools to detect complex patterns of protein sequences. However, the capability of PLMs to fully capture information on protein sequences might be limited by focusing on single…

Machine Learning · Computer Science 2025-05-27 Hazem Alsamkary , Mohamed Elshaffei , Mohamed Elkerdawy , Ahmed Elnaggar

Social media data has been of interest to Natural Language Processing (NLP) practitioners for over a decade, because of its richness in information, but also challenges for automatic processing. Since language use is more informal,…

Autoformalization, the conversion of natural language mathematics into formal languages, offers significant potential for advancing mathematical reasoning. However, existing efforts are limited to formal languages with substantial online…

Deciphering the function of unseen protein sequences is a fundamental challenge with broad scientific impact, yet most existing methods depend on task-specific adapters or large-scale supervised fine-tuning. We introduce the…

Machine Learning · Computer Science 2025-10-14 Xinhui Chen , Zuchao Li , Mengqi Gao , Yufeng Zhang , Chak Tou Leong , Haoyang Li , Jiaqi Chen

Computational biology and bioinformatics provide vast data gold-mines from protein sequences, ideal for Language Models taken from NLP. These LMs reach for new prediction frontiers at low inference costs. Here, we trained two…

Although large language models (LLMs) have advanced the state-of-the-art in NLP significantly, deploying them for downstream applications is still challenging due to cost, responsiveness, control, or concerns around privacy and security. As…

Computation and Language · Computer Science 2023-11-01 Dong-Ho Lee , Jay Pujara , Mohit Sewak , Ryen W. White , Sujay Kumar Jauhar

Large Language Models (LLMs) excel in handling general knowledge tasks, yet they struggle with user-specific personalization, such as understanding individual emotions, writing styles, and preferences. Personalized Large Language Models…

Artificial Intelligence · Computer Science 2025-09-23 Jiahong Liu , Zexuan Qiu , Zhongyang Li , Quanyu Dai , Wenhao Yu , Jieming Zhu , Minda Hu , Menglin Yang , Tat-Seng Chua , Irwin King

Large language models (LLMs) are increasingly used in natural language processing tasks. Recommender systems traditionally use methods such as collaborative filtering and matrix factorization, as well as advanced techniques like deep…

Information Retrieval · Computer Science 2024-09-13 Makbule Gulcin Ozsoy

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis…

Computation and Language · Computer Science 2025-03-07 Jiyue Jiang , Zikang Wang , Yuheng Shan , Heyan Chai , Jiayi Li , Zixian Ma , Xinrui Zhang , Yu Li

Motivated by the remarkable progress of large language models (LLMs) in objective tasks like mathematics and coding, there is growing interest in their potential to simulate human behavior--a capability with profound implications for…

Computation and Language · Computer Science 2026-01-23 Yuxuan Lei , Tianfu Wang , Jianxun Lian , Zhengyu Hu , Defu Lian , Xing Xie

Recent studies have demonstrated the feasibility of modeling single-cell data as natural languages and the potential of leveraging powerful large language models (LLMs) for understanding cell biology. However, a comprehensive evaluation of…

Quantitative Methods · Quantitative Biology 2025-05-14 Fan Zhang , Tianyu Liu , Zhihong Zhu , Hao Wu , Haixin Wang , Donghao Zhou , Yefeng Zheng , Kun Wang , Xian Wu , Pheng-Ann Heng
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