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Frontier Large Language Models (LLMs) pose unprecedented dual-use risks through the potential proliferation of chemical, biological, radiological, and nuclear (CBRN) weapons knowledge. We present the first comprehensive evaluation of 10…

Cryptography and Security · Computer Science 2025-10-27 Divyanshu Kumar , Nitin Aravind Birur , Tanay Baswa , Sahil Agarwal , Prashanth Harshangi

The rapid advancement of artificial intelligence has raised concerns about its potential to facilitate biological weapons development. We argue existing safety assessments of contemporary foundation AI models underestimate this risk,…

Computers and Society · Computer Science 2025-06-18 Roger Brent , T. Greg McKelvey

Discussions regarding the dual use of foundation models and the risks they pose have overwhelmingly focused on a narrow set of use cases and national security directives-in particular, how AI may enable the efficient construction of a class…

Computers and Society · Computer Science 2024-10-22 Heidy Khlaaf , Sarah Myers West , Meredith Whittaker

A concern about cutting-edge or "frontier" AI foundation models is that an adversary may use the models for preparing chemical, biological, radiological, nuclear, (CBRN), cyber, or other attacks. At least two methods can identify foundation…

Cryptography and Security · Computer Science 2024-05-21 Anthony M. Barrett , Krystal Jackson , Evan R. Murphy , Nada Madkour , Jessica Newman

Most frontier AI developers publicly document their safety evaluations of new AI models in model reports, including testing for chemical and biological (ChemBio) misuse risks. This practice provides a window into the methodology of these…

Computers and Society · Computer Science 2025-10-29 Tom Reed , Tegan McCaslin , Luca Righetti

The potential for rapidly-evolving frontier artificial intelligence (AI) models, especially large language models (LLMs), to facilitate bioterrorism or access to biological weapons has generated significant policy, academic, and public…

As foundation models grow in both popularity and capability, researchers have uncovered a variety of ways that the models can pose a risk to the model's owner, user, or others. Despite the efforts of measuring these risks via benchmarks and…

Cryptography and Security · Computer Science 2025-06-04 David Piorkowski , Michael Hind , John Richards , Jacquelyn Martino

Background: Large language models have demonstrated strong performance on general medical examinations, but subspecialty clinical reasoning remains challenging due to rapidly evolving guidelines and nuanced evidence hierarchies. Methods: We…

Artificial Intelligence · Computer Science 2026-02-19 Amir Hosseinian , MohammadReza Zare Shahneh , Umer Mansoor , Gilbert Szeto , Kirill Karlin , Nima Aghaeepour

If the authors of a recent Stanford report (Bommasani et al., 2021) on the opportunities and risks of "foundation models" are to be believed, these models represent a paradigm shift for AI and for the domains in which they will supposedly…

Computers and Society · Computer Science 2021-10-20 Su Lin Blodgett , Michael Madaio

To understand the risks posed by a new AI system, we must understand what it can and cannot do. Building on prior work, we introduce a programme of new "dangerous capability" evaluations and pilot them on Gemini 1.0 models. Our evaluations…

In pseudonymous online fora like Reddit, the benefits of self-disclosure are often apparent to users (e.g., I can vent about my in-laws to understanding strangers), but the privacy risks are more abstract (e.g., will my partner be able to…

Human-Computer Interaction · Computer Science 2024-12-20 Isadora Krsek , Anubha Kabra , Yao Dou , Tarek Naous , Laura A. Dabbish , Alan Ritter , Wei Xu , Sauvik Das

Large language models (LLMs) are increasingly deployed as tool-using agents, shifting safety concerns from harmful text generation to harmful task completion. Deployed systems often condition on user profiles or persistent memory, yet agent…

Artificial Intelligence · Computer Science 2026-03-18 Caglar Yildirim

Diffusion models (DMs) are regarded as one of the most advanced generative models today, yet recent studies suggest that they are vulnerable to backdoor attacks, which establish hidden associations between particular input patterns and…

Cryptography and Security · Computer Science 2024-08-23 Jiang Hao , Xiao Jin , Hu Xiaoguang , Chen Tianyou , Zhao Jiajia

Both model developers and policymakers seek to quantify and mitigate the risk of rapidly-evolving frontier artificial intelligence (AI) models, especially large language models (LLMs), to facilitate bioterrorism or access to biological…

High success rates on navigation-related tasks do not necessarily translate into reliable decision making by foundation models. To examine this gap, we evaluate current models on six diagnostic tasks spanning three settings: reasoning under…

Artificial Intelligence · Computer Science 2026-04-09 Jua Han , Jaeyoon Seo , Jungbin Min , Sieun Choi , Huichan Seo , Jihie Kim , Jean Oh

AI is undergoing a paradigm shift with the rise of models (e.g., BERT, DALL-E, GPT-3) that are trained on broad data at scale and are adaptable to a wide range of downstream tasks. We call these models foundation models to underscore their…

Machine Learning · Computer Science 2022-07-14 Rishi Bommasani , Drew A. Hudson , Ehsan Adeli , Russ Altman , Simran Arora , Sydney von Arx , Michael S. Bernstein , Jeannette Bohg , Antoine Bosselut , Emma Brunskill , Erik Brynjolfsson , Shyamal Buch , Dallas Card , Rodrigo Castellon , Niladri Chatterji , Annie Chen , Kathleen Creel , Jared Quincy Davis , Dora Demszky , Chris Donahue , Moussa Doumbouya , Esin Durmus , Stefano Ermon , John Etchemendy , Kawin Ethayarajh , Li Fei-Fei , Chelsea Finn , Trevor Gale , Lauren Gillespie , Karan Goel , Noah Goodman , Shelby Grossman , Neel Guha , Tatsunori Hashimoto , Peter Henderson , John Hewitt , Daniel E. Ho , Jenny Hong , Kyle Hsu , Jing Huang , Thomas Icard , Saahil Jain , Dan Jurafsky , Pratyusha Kalluri , Siddharth Karamcheti , Geoff Keeling , Fereshte Khani , Omar Khattab , Pang Wei Koh , Mark Krass , Ranjay Krishna , Rohith Kuditipudi , Ananya Kumar , Faisal Ladhak , Mina Lee , Tony Lee , Jure Leskovec , Isabelle Levent , Xiang Lisa Li , Xuechen Li , Tengyu Ma , Ali Malik , Christopher D. Manning , Suvir Mirchandani , Eric Mitchell , Zanele Munyikwa , Suraj Nair , Avanika Narayan , Deepak Narayanan , Ben Newman , Allen Nie , Juan Carlos Niebles , Hamed Nilforoshan , Julian Nyarko , Giray Ogut , Laurel Orr , Isabel Papadimitriou , Joon Sung Park , Chris Piech , Eva Portelance , Christopher Potts , Aditi Raghunathan , Rob Reich , Hongyu Ren , Frieda Rong , Yusuf Roohani , Camilo Ruiz , Jack Ryan , Christopher Ré , Dorsa Sadigh , Shiori Sagawa , Keshav Santhanam , Andy Shih , Krishnan Srinivasan , Alex Tamkin , Rohan Taori , Armin W. Thomas , Florian Tramèr , Rose E. Wang , William Wang , Bohan Wu , Jiajun Wu , Yuhuai Wu , Sang Michael Xie , Michihiro Yasunaga , Jiaxuan You , Matei Zaharia , Michael Zhang , Tianyi Zhang , Xikun Zhang , Yuhui Zhang , Lucia Zheng , Kaitlyn Zhou , Percy Liang

Concept Bottleneck Models (CBMs) have emerged as a cornerstone approach for interpretable machine learning, providing human-understandable intermediate representations through explicit concept activations. However, this interpretability…

Machine Learning · Computer Science 2026-05-26 Aditya Sridhar

Face recognition (FR) has been applied to nearly every aspect of daily life, but it is always accompanied by the underlying risk of leaking private information. At present, almost all attack models against FR rely heavily on the presence of…

Computer Vision and Pattern Recognition · Computer Science 2024-01-26 Yuanqing Huang , Huilong Chen , Yinggui Wang , Lei Wang

The combination of Deep Learning techniques and Raman spectroscopy shows great potential offering precise and prompt identification of pathogenic bacteria in clinical settings. However, the traditional closed-set classification approaches…

Quantitative Methods · Quantitative Biology 2023-10-24 Yaroslav Balytskyi , Nataliia Kalashnyk , Inna Hubenko , Alina Balytska , Kelly McNear

Adversarial examples crafted by an explicit adversary have attracted significant attention in machine learning. However, the security risk posed by a potential false friend has been largely overlooked. In this paper, we unveil the threat of…

Machine Learning · Computer Science 2021-12-14 Lue Tao , Lei Feng , Jinfeng Yi , Songcan Chen
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