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Protein secondary structure prediction is an important problem in bioinformatics. Inspired by the recent successes of deep neural networks, in this paper, we propose an end-to-end deep network that predicts protein secondary structures from…

Biomolecules · Quantitative Biology 2016-04-27 Zhen Li , Yizhou Yu

In this work we detail a novel open source library, called MMLSpark, that combines the flexible deep learning library Cognitive Toolkit, with the distributed computing framework Apache Spark. To achieve this, we have contributed Java…

The automation of scientific research workflows has emerged as a transformative frontier in artificial intelligence, yet existing autonomous research agents remain largely domain-agnostic, lacking the specialized reasoning, method…

Artificial Intelligence · Computer Science 2026-05-05 Bing Zhou , Xiao Huang , Huan Ning , Qiusheng Wu , Diya Li , Ziyi Zhang

Distributed-Something coordinates the distribution of any Dockerized workflow using on-demand computational infrastructure from Amazon Web Services to enable at-scale workflows where neither computing power nor data storage are limited by…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-07-03 Erin Weisbart , Beth A. Cimini

Principal Component Analysis (PCA) and its nonlinear extension Kernel PCA (KPCA) are widely used across science and industry for data analysis and dimensionality reduction. Modern deep learning tools have achieved great empirical success,…

Machine Learning · Computer Science 2023-02-23 Francesco Tonin , Qinghua Tao , Panagiotis Patrinos , Johan A. K. Suykens

Secure aggregation is widely used in horizontal Federated Learning (FL), to prevent leakage of training data when model updates from data owners are aggregated. Secure aggregation protocols based on Homomorphic Encryption (HE) have been…

Cryptography and Security · Computer Science 2022-08-16 Zizhen Liu , Si Chen , Jing Ye , Junfeng Fan , Huawei Li , Xiaowei Li

We present a generalization of the well-known problem of learning k-juntas in R^n, and a novel tensor algorithm for unraveling the structure of high-dimensional distributions. Our algorithm can be viewed as a higher-order extension of…

Computational Complexity · Computer Science 2012-04-17 Santosh S. Vempala , Ying Xiao

Nonlinear component analysis such as kernel Principle Component Analysis (KPCA) and kernel Canonical Correlation Analysis (KCCA) are widely used in machine learning, statistics and data analysis, but they can not scale up to big datasets.…

Machine Learning · Computer Science 2016-01-12 Bo Xie , Yingyu Liang , Le Song

Sparse principal component analysis (PCA) improves interpretability of the classic PCA by introducing sparsity into the dimension-reduction process. Optimization models for sparse PCA, however, are generally non-convex, non-smooth and more…

Optimization and Control · Mathematics 2024-01-09 Lei Wang , Xin Liu , Yin Zhang

Principal Subspace Analysis (PSA) -- and its sibling, Principal Component Analysis (PCA) -- is one of the most popular approaches for dimensionality reduction in signal processing and machine learning. But centralized PSA/PCA solutions are…

Machine Learning · Computer Science 2021-11-25 Arpita Gang , Bingqing Xiang , Waheed U. Bajwa

AlphaFold predicts protein structures from the amino acid sequence at or near experimental resolution, solving the 50-year-old protein folding challenge, leading to progress by transforming large-scale genomics data into protein structures.…

Biomolecules · Quantitative Biology 2021-11-16 Bozitao Zhong , Xiaoming Su , Minhua Wen , Sichen Zuo , Liang Hong , James Lin

Principal component analysis (PCA) is a key tool in the field of data dimensionality reduction. Various methods have been proposed to extend PCA to the union of subspace (UoS) setting for clustering data that comes from multiple subspaces…

Machine Learning · Statistics 2026-01-21 Javier Salazar Cavazos , Jeffrey A Fessler , Laura Balzano

This paper presents a new software model designed for distributed sonic signal detection runtime using machine learning algorithms called DeLMA. A new algorithm--Acoustic Data-mining Accelerator (ADA)--is also presented. ADA is a robust yet…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-09-14 Peter Dugan , John Zollweg , Marian Popescu , Denise Risch , Herve Glotin , Yann LeCun , and Christopher Clark

Today's scientific challenges, from climate modeling to Inertial Confinement Fusion design to novel material design, require exploring huge design spaces. In order to enable high-impact scientific discovery, we need to scale up our ability…

Distributed system as e.g. artificial immune systems, complex adaptive systems, or multi-agent systems are widely used in Computer Science, e.g. for network security, optimisations, or simulations. In these systems, small entities move…

Multiagent Systems · Computer Science 2008-05-14 Michael Hilker

The unprecedented volume of data from the Square Kilometre Array (SKA) telescopes will require the implementation of robust and solid strategies for efficient data processing and management. In this context, the SKA Regional Centre Network…

Instrumentation and Methods for Astrophysics · Physics 2025-12-22 Edgar Ribeiro João , Manuel Parra-Royón , Julián Garrido

Microservice architecture is widely adopted among distributed systems. It follows the modular approach that decomposes large software applications into independent services. Kubernetes has become the standard tool for managing these…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-02-07 Kavindu Gunathilake , Indrajith Ekanayake

Nowadays, with the widespread of smartphones and other portable gadgets equipped with a variety of sensors, data is ubiquitous available and the focus of machine learning has shifted from being able to infer from small training samples to…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-07-07 Radu Cristian Ionescu

In this paper we present a formal description of PROSA, a P2P resource management system heavily inspired by social networks. Social networks have been deeply studied in the last two decades in order to understand how communities of people…

Distributed, Parallel, and Cluster Computing · Computer Science 2007-05-23 V. Nicosia , G. Mangioni , V. Carchiolo , M. Malgeri

Research increasingly relies on computational methods to analyze experimental data and predict molecular properties. Current approaches often require researchers to use a variety of tools for statistical analysis and machine learning,…

Quantitative Methods · Quantitative Biology 2025-12-01 Luke Rimmo Lego , Samantha Gauthier , Denver Jn. Baptiste
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