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The human brain forms functional networks on all spatial scales. Modern fMRI scanners allow to resolve functional brain data in high resolutions, allowing to study large-scale networks that relate to cognitive processes. The analysis of…

Neurons and Cognition · Quantitative Biology 2019-05-14 Melanie Weber , Johannes Stelzer , Emil Saucan , Alexander Naitsat , Gabriele Lohmann , Jürgen Jost

A complete understanding of the brain requires an integrated description of the numerous scales of neural organization. It means studying the interplay of genes, synapses, and even whole brain regions which ultimately leads to different…

Neurons and Cognition · Quantitative Biology 2022-08-09 Charley Presigny , Fabrizio De Vico Fallani

At rest, human brain functional networks display striking modular architecture in which coherent clusters of brain regions are activated. The modular account of brain function is pervasive, reliable, and reproducible. Yet, a complementary…

Simplicial complexes are generalized network structures able to encode interactions occurring between more than two nodes. Simplicial complexes describe a large variety of complex interacting systems ranging from brain networks, to social…

Physics and Society · Physics 2016-06-22 Owen T. Courtney , Ginestra Bianconi

New representations of tree-structured data objects, using ideas from topological data analysis, enable improved statistical analyses of a population of brain artery trees. A number of representations of each data tree arise from…

Applications · Statistics 2014-11-26 Paul Bendich , J. S. Marron , Ezra Miller , Alex Pieloch , Sean Skwerer

Deep neural network architectures often consist of repetitive structural elements. We introduce an approach that reveals these patterns and can be broadly applied to the study of deep learning. Similarly to how a power strip helps untangle…

Statistical Mechanics · Physics 2025-07-03 Donghee Lee , Hye-Sung Lee , Jaeok Yi

Correlations in the signal observed via functional Magnetic Resonance Imaging (fMRI), are expected to reveal the interactions in the underlying neural populations through hemodynamic response. In particular, they highlight distributed set…

Applications · Statistics 2012-02-07 Gaël Varoquaux , Alexandre Gramfort , Jean Baptiste Poline , Bertrand Thirion

We study how the topology of a data set $M = M_a \cup M_b \subseteq \mathbb{R}^d$, representing two classes $a$ and $b$ in a binary classification problem, changes as it passes through the layers of a well-trained neural network, i.e., with…

Machine Learning · Computer Science 2020-04-14 Gregory Naitzat , Andrey Zhitnikov , Lek-Heng Lim

Higher-order information is crucial for relational learning in many domains where relationships extend beyond pairwise interactions. Hypergraphs provide a natural framework for modeling such relationships, which has motivated recent…

Machine Learning · Computer Science 2025-02-21 Raphael Pellegrin , Lukas Fesser , Melanie Weber

Complex networks are frequently employed to model physical or virtual complex systems. When certain entities exist across multiple systems simultaneously, unveiling their corresponding relationships across the networks becomes crucial. This…

Physics and Society · Physics 2025-04-16 Rui Tang , Ziyun Yong , Shuyu Jiang , Xingshu Chen , Yaofang Liu , Yi-Cheng Zhang , Gui-Quan Sun , Wei Wang

In the last years complex networks tools contributed to provide insights on the structure of research, through the study of collaboration, citation and co-occurrence networks. The network approach focuses on pairwise relationships, often…

Physics and Society · Physics 2018-03-14 Vsevolod Salnikov , Daniele Cassese , Renaud Lambiotte , Nick S. Jones

Complex systems, represented as dynamic networks, comprise of components that influence each other via direct and/or indirect interactions. Recent research has shown the importance of using Higher-Order Networks (HONs) for modeling and…

Social and Information Networks · Computer Science 2020-10-13 Mandana Saebi , Jian Xu , Lance M. Kaplan , Bruno Ribeiro , Nitesh V. Chawla

Encoding brain regions and their connections as a network of nodes and edges captures many of the possible paths along which information can be transmitted as humans process and perform complex behaviors. Because cognitive processes involve…

Neurons and Cognition · Quantitative Biology 2016-12-21 Ann Sizemore , Chad Giusti , Ari Kahn , Richard F. Betzel , Danielle S. Bassett

Dense Associative Memories or Modern Hopfield Networks have many appealing properties of associative memory. They can do pattern completion, store a large number of memories, and can be described using a recurrent neural network with a…

Neural and Evolutionary Computing · Computer Science 2021-07-29 Dmitry Krotov

In the past two decades, extensive research has been conducted on the (co)homology of various models of random simplicial complexes. So far, it has always been examined merely as a list of groups. This paper expands upon this by describing…

Algebraic Topology · Mathematics 2024-08-21 Jon V. Kogan

Higher-order interactions underlie complex phenomena in systems such as biological and artificial neural networks, but their study is challenging due to the scarcity of tractable models. By leveraging a generalisation of the maximum entropy…

Disordered Systems and Neural Networks · Physics 2025-12-10 Miguel Aguilera , Pablo A. Morales , Fernando E. Rosas , Hideaki Shimazaki

We use topological data analysis (TDA) to study how data transforms as it passes through successive layers of a deep neural network (DNN). We compute the persistent homology of the activation data for each layer of the network and summarize…

Machine Learning · Computer Science 2022-05-09 Matthew Wheeler , Jose Bouza , Peter Bubenik

The brain is a highly complex system. Most of such complexity stems from the intermingled connections between its parts, which give rise to rich dynamics and to the emergence of high-level cognitive functions. Disentangling the underlying…

Neurons and Cognition · Quantitative Biology 2023-08-14 Vito Dichio , Fabrizio De Vico Fallani

The effectiveness of Spatio-temporal Graph Neural Networks (STGNNs) in time-series applications is often limited by their dependence on fixed, hand-crafted input graph structures. Motivated by insights from the Topological Data Analysis…

Machine Learning · Computer Science 2025-03-20 Viet The Nguyen , Duy Anh Pham , An Thai Le , Jans Peter , Gunther Gust

Understanding the response of an output variable to multi-dimensional inputs lies at the heart of many data exploration endeavours. Topology-based methods, in particular Morse theory and persistent homology, provide a useful framework for…

Graphics · Computer Science 2022-08-16 Yarden Livnat , Dan Maljovec , Attila Gyulassy , Dr Baptiste Mouginot , Valerio Pascucci
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