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Inferring the structural properties of a protein from its amino acid sequence is a challenging yet important problem in biology. Structures are not known for the vast majority of protein sequences, but structure is critical for…

Machine Learning · Computer Science 2019-10-17 Tristan Bepler , Bonnie Berger

We consider the problem of learning discriminative representations for data in a high-dimensional space with distribution supported on or around multiple low-dimensional linear subspaces. That is, we wish to compute a linear injective map…

Machine Learning · Statistics 2022-10-07 Druv Pai , Michael Psenka , Chih-Yuan Chiu , Manxi Wu , Edgar Dobriban , Yi Ma

Graph learning is currently dominated by graph kernels, which, while powerful, suffer some significant limitations. Convolutional Neural Networks (CNNs) offer a very appealing alternative, but processing graphs with CNNs is not trivial. To…

Computer Vision and Pattern Recognition · Computer Science 2019-09-04 Antoine Jean-Pierre Tixier , Giannis Nikolentzos , Polykarpos Meladianos , Michalis Vazirgiannis

The representation of graphs is commonly based on the adjacency matrix concept. This formulation is the foundation of most algebraic and computational approaches to graph processing. The advent of deep learning language models offers a wide…

Artificial Intelligence · Computer Science 2025-12-16 Ezequiel Lopez-Rubio

Accurately predicting drug-target binding affinity (DTA) in silico is a key task in drug discovery. Most of the conventional DTA prediction methods are simulation-based, which rely heavily on domain knowledge or the assumption of having the…

Machine Learning · Computer Science 2020-04-06 Xuan Lin

Graph neural networks (GNNs) have become a powerful tool for processing graph-structured data but still face challenges in effectively aggregating and propagating information between layers, which limits their performance. We tackle this…

Machine Learning · Computer Science 2023-02-09 Maxim Fishman , Chaim Baskin , Evgenii Zheltonozhskii , Almog David , Ron Banner , Avi Mendelson

Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the…

Genomics · Quantitative Biology 2015-04-09 Andrew L. Beam , Alison Motsinger-Reif , Jon Doyle

Classical supervised classification tasks search for a nonlinear mapping that maps each encoded feature directly to a probability mass over the labels. Such a learning framework typically lacks the intuition that encoded features from the…

Computer Vision and Pattern Recognition · Computer Science 2020-06-11 Cat P. Le , Yi Zhou , Jie Ding , Vahid Tarokh

Raster well-log images are digital representations of well-logs data generated over the years. Raster digital well logs represent bitmaps of the log image in a rectangular array of black (zeros) and white dots (ones) called pixels. Experts…

Geophysics · Physics 2022-10-12 M Quamer Nasim , Narendra Patwardhan , Tannistha Maiti , Tarry Singh

Learning vectorized embeddings is fundamental to many recommender systems for user-item matching. To enable efficient online inference, representation binarization, which embeds latent features into compact binary sequences, has recently…

Information Retrieval · Computer Science 2025-06-04 Yankai Chen , Yue Que , Xinni Zhang , Chen Ma , Irwin King

In Natural Language Processing (NLP), it is important to detect the relationship between two sequences or to generate a sequence of tokens given another observed sequence. We call the type of problems on modelling sequence pairs as sequence…

Computation and Language · Computer Science 2018-10-26 Lei Yu

Sequential data such as time series, video, or text can be challenging to analyse as the ordered structure gives rise to complex dependencies. At the heart of this is non-commutativity, in the sense that reordering the elements of a…

Machine Learning · Computer Science 2021-08-02 Csaba Toth , Patric Bonnier , Harald Oberhauser

Event sequence data record series of discrete events in the time order of occurrence. They are commonly observed in a variety of applications ranging from electronic health records to network logs, with the characteristics of large-scale,…

Human-Computer Interaction · Computer Science 2020-06-26 Yi Guo , Shunan Guo , Zhuochen Jin , Smiti Kaul , David Gotz , Nan Cao

Regression on medical image sequences can capture temporal image pattern changes and predict images at missing or future time points. However, existing geodesic regression methods limit their regression performance by a strong underlying…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Hao Bai , Yi Hong

Time series data, defined by equally spaced points over time, is essential in fields like medicine, telecommunications, and energy. Analyzing it involves tasks such as classification, clustering, prototyping, and regression. Classification…

Machine Learning · Computer Science 2025-02-27 Ali Ismail-Fawaz

Modern data analysis pipelines are becoming increasingly complex due to the presence of multi-view information sources. While graphs are effective in modeling complex relationships, in many scenarios a single graph is rarely sufficient to…

Machine Learning · Statistics 2019-04-02 Uday Shankar Shanthamallu , Jayaraman J. Thiagarajan , Huan Song , Andreas Spanias

Recent studies in DNA sequence classification have leveraged sophisticated machine learning techniques, achieving notable accuracy in categorizing complex genomic data. Among these, methods such as k-mer counting have proven effective in…

Genomics · Quantitative Biology 2024-01-26 Şükrü Ozan

Graph-based convolutional model such as non-local block has shown to be effective for strengthening the context modeling ability in convolutional neural networks (CNNs). However, its pixel-wise computational overhead is prohibitive which…

Computer Vision and Pattern Recognition · Computer Science 2021-09-01 Xiangtai Li , Xia Li , Ansheng You , Li Zhang , Guangliang Cheng , Kuiyuan Yang , Yunhai Tong , Zhouchen Lin

Semi-supervised learning (SSL) has made notable advancements in medical image segmentation (MIS), particularly in scenarios with limited labeled data and significantly enhancing data utilization efficiency. Previous methods primarily focus…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Mengzhu Wang , Jiao Li , Houcheng Su , Nan Yin , Liang Yang , Shen Li

Analysis of single-cell RNA sequencing data is often conducted through network projections such as coexpression networks, primarily due to the abundant availability of network analysis tools for downstream tasks. However, this approach has…

Quantitative Methods · Quantitative Biology 2025-12-24 Wan He , Daniel I. Bolnick , Samuel V. Scarpino , Tina Eliassi-Rad