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In this article, we propose new Bayesian methods for selecting and estimating a sparse coefficient vector for skewed heteroscedastic response. Our novel Bayesian procedures effectively estimate the median and other quantile functions,…

Methodology · Statistics 2017-07-04 Libo Wang , Yuanyuan Tang , Debajyoti Sinha , Debdeep Pati , Stuart Lipsitz

We consider the problem of inferring the values of an arbitrary set of variables (e.g., risk of diseases) given other observed variables (e.g., symptoms and diagnosed diseases) and high-dimensional signals (e.g., MRI images or EEG). This is…

Machine Learning · Statistics 2019-02-07 Hao Wang , Chengzhi Mao , Hao He , Mingmin Zhao , Tommi S. Jaakkola , Dina Katabi

Dimension reduction techniques are among the most essential analytical tools in the analysis of high-dimensional data. Generalized principal component analysis (PCA) is an extension to standard PCA that has been widely used to identify…

Structural breaks have been commonly seen in applications. Specifically for detection of change points in time, research gap still remains on the setting in ultra high dimension, where the covariates may bear spurious correlations. In this…

Methodology · Statistics 2021-06-10 Xin Liu , Liwen Zhang , Zhen Zhang

In segmentation problems, inference on change-point position and model selection are two difficult issues due to the discrete nature of change-points. In a Bayesian context, we derive exact, non-asymptotic, explicit and tractable formulae…

Computation · Statistics 2015-12-31 Guillem Rigaill , Emilie Lebarbier , Stéphane Robin

Reliable real-time analysis of sensor data is essential for structural health monitoring (SHM) of high-value assets, yet a major challenge is to obtain spatially resolved full-field aleatoric and epistemic uncertainties for trustworthy…

Machine Learning · Computer Science 2025-12-04 Hanbin Cho , Jecheon Yu , Hyeonbin Moon , Jiyoung Yoon , Junhyeong Lee , Giyoung Kim , Jinhyoung Park , Seunghwa Ryu

Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

The analysis of the three-dimensional structure of proteins is an important topic in molecular biochemistry. Structure plays a critical role in defining the function of proteins and is more strongly conserved than amino acid sequence over…

Applications · Statistics 2015-01-19 Abel Rodriguez , Scott C. Schmidler

Feature screening approaches are effective in selecting active features from data with ultrahigh dimensionality and increasing complexity; however, the majority of existing feature screening approaches are either restricted to a univariate…

Methodology · Statistics 2023-05-09 Shaofei Zhao , Guifang Fu

Multidimensional scaling (MDS) is a widely used approach to representing high-dimensional, dependent data. MDS works by assigning each observation a location on a low-dimensional geometric manifold, with distance on the manifold…

Methodology · Statistics 2023-08-16 Bolun Liu , Shane Lubold , Adrian E. Raftery , Tyler H. McCormick

Recently, several Bayesian deep learning methods have been proposed for semi-supervised medical image segmentation. Although they have achieved promising results on medical benchmarks, some problems are still existing. Firstly, their…

Computer Vision and Pattern Recognition · Computer Science 2022-06-22 Jianfeng Wang , Thomas Lukasiewicz

Feature screening is a powerful tool in the analysis of high dimensional data. When the sample size $N$ and the number of features $p$ are both large, the implementation of classic screening methods can be numerically challenging. In this…

Methodology · Statistics 2019-03-12 Xingxiang Li , Runze Li , Zhiming Xia , Chen Xu

The ability to engineer optimized protein variants has transformative potential for biotechnology and medicine. Prior sequence-based optimization methods struggle with the high-dimensional complexities due to the epistasis effect and the…

Artificial Intelligence · Computer Science 2026-01-19 Jiahao Wang , Shuangjia Zheng

This paper presents a hierarchical Bayesian model to reconstruct sparse images when the observations are obtained from linear transformations and corrupted by an additive white Gaussian noise. Our hierarchical Bayes model is well suited to…

Data Analysis, Statistics and Probability · Physics 2011-01-19 Nicolas Dobigeon , Alfred O. Hero , Jean-Yves Tourneret

Screening mammograms is the gold standard for detecting breast cancer early. While a good amount of work has been performed on mammography image classification, especially with deep neural networks, there has not been much exploration into…

Machine Learning · Computer Science 2020-08-14 Anika Tabassum , Naimul Khan

While previous distribution shift detection approaches can identify if a shift has occurred, these approaches cannot localize which specific features have caused a distribution shift -- a critical step in diagnosing or fixing any underlying…

Machine Learning · Computer Science 2021-07-16 Sean Kulinski , Saurabh Bagchi , David I. Inouye

Learning the structure of Bayesian networks from data is known to be a computationally challenging, NP-hard problem. The literature has long investigated how to perform structure learning from data containing large numbers of variables,…

Computation · Statistics 2019-10-25 Marco Scutari , Claudia Vitolo , Allan Tucker

A ubiquitous feature of data of our era is their extra-large sizes and dimensions. Analyzing such high-dimensional data poses significant challenges, since the feature dimension is often much larger than the sample size. This thesis…

Statistics Theory · Mathematics 2025-09-11 Kai Yang

Computer experiments are becoming increasingly important in scientific investigations. In the presence of uncertainty, analysts employ probabilistic sensitivity methods to identify the key-drivers of change in the quantities of interest.…

Methodology · Statistics 2024-07-02 Isadora Antoniano-Villalobos , Emanuele Borgonovo , Xuefei Lu

Locks and dams are critical pieces of inland waterways. However, many components of existing locks have been in operation past their designed lifetime. To ensure safe and cost effective operations, it is therefore important to monitor the…

Applications · Statistics 2018-12-14 Matthew Parno , Devin O'Connor , Matthew Smith