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In the stochastic formulation of chemical kinetics, the stationary moments of the population count of species can be described via a set of linear equations. However, except for some specific cases such as systems with linear reaction…

Quantitative Methods · Quantitative Biology 2017-01-02 Khem Raj Ghusinga , Cesar A. Vargas-Garcia , Andrew Lamperski , Abhyudai Singh

In this paper, the stability of fractional differential equations (FDEs) with unknown parameters is studied. FDEs bring many advantages to model the physical systems in the nature or man-made systems in the industry. Because this…

Systems and Control · Computer Science 2020-08-13 Mehmet Emir Koksal

We explore situations in which certain stochastic and high-dimensional deterministic systems behave effectively as low-dimensional dynamical systems. We define and study moment maps, maps on spaces of low-order moments of evolving…

Other Condensed Matter · Physics 2016-08-31 D. Barkley , I. G. Kevrekidis , A. M. Stuart

Model-based prediction of stochastic noise in biomolecular reactions often resorts to approximation with unknown precision. As a result, unexpected stochastic fluctuation causes a headache for the designers of biomolecular circuits. This…

Molecular Networks · Quantitative Biology 2018-08-07 Yuta Sakurai , Yutaka Hori

Moment dynamics in stochastic chemical kinetics often involve an infinite chain of coupled equations, where lower-order moments depend on higher-order ones, making them analytically intractable. Moment bounding via semidefinite programming…

Optimization and Control · Mathematics 2026-04-07 Tomoki Sadatoshi , Antonis Papachristodoulou , Yutaka Hori

The dynamics of many open quantum systems are described by stochastic master equations. In the discrete-time case, we recall the structure of the derived quantum filter governing the evolution of the density operator conditioned to the…

Optimization and Control · Mathematics 2015-03-23 Pierre Six , Philippe Campagne-Ibarcq , Landry Bretheau , Benjamin Huard , Pierre Rouchon

In a wide range of applications, the stochastic properties of the observed time series change over time. The changes often occur gradually rather than abruptly: the properties are (approximately) constant for some time and then slowly start…

Methodology · Statistics 2015-04-03 Michael Vogt , Holger Dette

In a wide range of applications, the stochastic properties of the observed time series change over time. The changes often occur gradually rather than abruptly: the prop- erties are (approximately) constant for some time and then slowly…

Methodology · Statistics 2014-03-18 Michael Vogt , Holger Dette

We study the structure of stationary non equilibrium states for interacting particle systems from a microscopic viewpoint. In particular we discuss two different discrete geometric constructions. We apply both of them to determine non…

Statistical Mechanics · Physics 2017-09-15 Leonardo De Carlo , Davide Gabrielli

Homeostasis, broadly speaking, refers to the maintenance of a stable internal state when faced with external stimuli. Failure to manage these regulatory processes can lead to different diseases or death. Most physiologists and cell…

Dynamical Systems · Mathematics 2025-05-20 Christopher J. Ryzowicz , Richard Bertram , Bhargav R. Karamched

Inferring parameters of models of biochemical kinetics from single-cell data remains challenging because of the uncertainty arising from the intractability of the likelihood function of stochastic reaction networks. Such uncertainty falls…

Quantitative Methods · Quantitative Biology 2025-01-14 Zekai Li , Mauricio Barahona , Philipp Thomas

Fractional derivative and delay are important tools in modeling memory properties in the natural system. This work deals with the stability analysis of a fractional order delay differential equation \begin{equation*} D^\alpha x(t)=\delta…

Dynamical Systems · Mathematics 2022-08-29 Sachin Bhalekar , Deepa Gupta

Homeostasis refers to a phenomenon whereby the output $x_o$ of a system is approximately constant on variation of an input $\mathcal{I}$. Homeostasis occurs frequently in biochemical networks and in other networks of interacting elements…

Molecular Networks · Quantitative Biology 2021-05-27 Yangyang Wang , Zhengyuan Huang , Fernando Antoneli , Martin Golubitsky

The work analyzes the stability of the quantum eigenstates when they are submitted to fluctuations by using the stochastic generalization of the Madelung quantum hydrodynamic approach. In the limit of sufficiently slow kinetics, the quantum…

Quantum Physics · Physics 2020-12-01 Simone Chiarelli , Piero Chiarelli

Homeostasis occurs in a biological system when a chosen output variable remains approximately constant despite changes in an input variable. In this work we specifically focus on biological systems which may be represented as chemical…

Quantitative Methods · Quantitative Biology 2024-07-19 Jiaxin Jin , Grzegorz A. Rempala

Many systems in biology, physics and engineering can be described by systems of ordinary differential equation containing many parameters. When studying the dynamic behavior of these large, nonlinear systems, it is useful to identify and…

Molecular Networks · Quantitative Biology 2016-04-13 Heather A. Harrington , Dhagash Mehta , Helen M. Byrne , Jonathan D. Hauenstein

Straightforward method for the derivation of linearized version of stochastic stability analysis of the nonlinear differential equations is presented. Methods for the study of large time behavior of the moments are exposed. These general…

Mathematical Physics · Physics 2012-12-07 Gyorgy Steinbrecher , Xavier Garbet

Changes in environmental or system parameters often drive major biological transitions, including ecosystem collapse, disease outbreaks, and tumor development. Analyzing the stability of steady states in dynamical systems provides critical…

Populations and Evolution · Quantitative Biology 2025-05-02 Joseph Cummings , Kyle J. -M. Dahlin , Elizabeth Gross , Jonathan D. Hauenstein

We consider stochastic models of chemical reaction networks with time dependent input rates and several types of molecules. We prove that, in despite of strong time dependence of input rates, there is a kind of homeostasis phenomenon: far…

Mathematical Physics · Physics 2012-01-18 V. A. Malyshev , A. D. Manita , A. A. Zamyatin

Statistical models provide a powerful and useful class of approximations for calculating reaction rates by bypassing the need for detailed, and often difficult, dynamical considerations. Such approaches invariably invoke specific…

Chemical Physics · Physics 2020-04-01 Sourav Karmakar , Pankaj Kumar Yadav , Srihari Keshavamurthy
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