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Medical image registration is critical for aligning anatomical structures across imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound. Among existing techniques, non-rigid registration (NRR)…

Image and Video Processing · Electrical Eng. & Systems 2025-12-17 Sneha Sree C. , Dattesh Shanbhag , Sudhanya Chatterjee

Since its introduction, UNet has been leading a variety of medical image segmentation tasks. Although numerous follow-up studies have also been dedicated to improving the performance of standard UNet, few have conducted in-depth analyses of…

Image and Video Processing · Electrical Eng. & Systems 2024-06-24 Wenhui Zhu , Xiwen Chen , Peijie Qiu , Mohammad Farazi , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

We propose a fully unsupervised multi-modal deformable image registration method (UMDIR), which does not require any ground truth deformation fields or any aligned multi-modal image pairs during training. Multi-modal registration is a key…

Computer Vision and Pattern Recognition · Computer Science 2019-03-25 Chen Qin , Bibo Shi , Rui Liao , Tommaso Mansi , Daniel Rueckert , Ali Kamen

Background: In MR-guided proton therapy planning, aligning MR and CT images is key for MR-based CT synthesis, especially in mobile regions like the head-and-neck. Misalignments here can lead to less accurate synthetic CT (sCT) images,…

Deformable medical image registration is an essential task in computer-assisted interventions. This problem is particularly relevant to oncological treatments, where precise image alignment is necessary for tracking tumor growth, assessing…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Stefano Fogarollo , Gregor Laimer , Reto Bale , Matthias Harders

Deformable medical image registration is a fundamental task in medical image analysis with applications in disease diagnosis, treatment planning, and image-guided interventions. Despite significant advances in deep learning based…

Machine Learning · Computer Science 2026-02-10 Muhammad Zafar Iqbal , Ghazanfar Farooq Siddiqui , Anwar Ul Haq , Imran Razzak

Recent deep learning-based methods have shown promising results and runtime advantages in deformable image registration. However, analyzing the effects of hyperparameters and searching for optimal regularization parameters prove to be too…

Computer Vision and Pattern Recognition · Computer Science 2021-07-06 Tony C. W. Mok , Albert C. S. Chung

Medical image registration is crucial for various clinical and research applications including disease diagnosis or treatment planning which require alignment of images from different modalities, time points, or subjects. Traditional…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Ahsan Raza Siyal , Markus Haltmeier , Ruth Steiger , Malik Galijasevic , Elke Ruth Gizewski , Astrid Ellen Grams

In computer- and robot-assisted orthopedic surgery (CAOS), patient-specific surgical plans derived from preoperative imaging define target locations and implant trajectories. During surgery, these plans must be accurately transferred,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Luohong Wu , Matthias Seibold , Nicola A. Cavalcanti , Yunke Ao , Roman Flepp , Aidana Massalimova , Lilian Calvet , Philipp Fürnstahl

Registration plays an important role in medical image analysis. Deep learning-based methods have been studied for medical image registration, which leverage convolutional neural networks (CNNs) for efficiently regressing a dense deformation…

Computer Vision and Pattern Recognition · Computer Science 2022-08-16 Xiaoru Gao , GuoYan Zheng

In clinical practice, imaging modalities with functional characteristics, such as positron emission tomography (PET) and fractional anisotropy (FA), are often aligned with a structural reference (e.g., MRI, CT) for accurate interpretation…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Kyobin Choo , Hyunkyung Han , Jinyeong Kim , Chanyong Yoon , Seong Jae Hwang

The growing complexity and scale of visual model pre-training have made developing and deploying multi-task computer-aided diagnosis (CAD) systems increasingly challenging and resource-intensive. Furthermore, the medical imaging community…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Yitao Zhu , Yuan Yin , Zhenrong Shen , Zihao Zhao , Haiyu Song , Sheng Wang , Dinggang Shen , Qian Wang

In the field of clinical medicine, computed tomography (CT) is an effective medical imaging modality for the diagnosis of various pathologies. Compared with X-ray images, CT images can provide more information, including multi-planar slices…

Image and Video Processing · Electrical Eng. & Systems 2024-03-08 Jing Hu , Qinrui Fan , Shu Hu , Siwei Lyu , Xi Wu , Xin Wang

Cortical surface registration is a fundamental tool for neuroimaging analysis that has been shown to improve the alignment of functional regions relative to volumetric approaches. Classically, image registration is performed by optimizing a…

Computer Vision and Pattern Recognition · Computer Science 2022-03-25 Mohamed A. Suliman , Logan Z. J. Williams , Abdulah Fawaz , Emma C. Robinson

Surgical navigation based on multimodal image registration has played a significant role in providing intraoperative guidance to surgeons by showing the relative position of the target area to critical anatomical structures during surgery.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Jiazheng Wang , Zeyu Liu , Min Liu , Xiang Chen , Xinyao Yu , Yaonan Wang , Hang Zhang

While deep learning models have become the predominant method for medical image segmentation, they are typically not capable of generalizing to unseen segmentation tasks involving new anatomies, image modalities, or labels. Given a new…

Computer Vision and Pattern Recognition · Computer Science 2023-04-14 Victor Ion Butoi , Jose Javier Gonzalez Ortiz , Tianyu Ma , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

In order to tackle the difficulty associated with the ill-posed nature of the image registration problem, regularization is often used to constrain the solution space. For most learning-based registration approaches, the regularization…

Computer Vision and Pattern Recognition · Computer Science 2022-03-03 Zhe Xu , Jie Luo , Donghuan Lu , Jiangpeng Yan , Sarah Frisken , Jayender Jagadeesan , William Wells , Xiu Li , Yefeng Zheng , Raymond Tong

The federated learning paradigm is wellsuited for the field of medical image analysis, as it can effectively cope with machine learning on isolated multicenter data while protecting the privacy of participating parties. However, current…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Zhekai Zhou , Guibo Luo , Mingzhi Chen , Zhenyu Weng , Yuesheng Zhu

Medical image registration drives quantitative analysis across organs, modalities, and patient populations. Recent deep learning methods often combine low-level "trend-driven" computational blocks from computer vision, such as large-kernel…

Image and Video Processing · Electrical Eng. & Systems 2025-12-02 Bailiang Jian , Jiazhen Pan , Rohit Jena , Morteza Ghahremani , Hongwei Bran Li , Daniel Rueckert , Christian Wachinger , Benedikt Wiestler

Multi-modality medical images can provide relevant or complementary information for a target (organ, tumor or tissue). Registering multi-modality images to a common space can fuse these comprehensive information, and bring convenience for…

Image and Video Processing · Electrical Eng. & Systems 2021-08-31 Wangbin Ding , Lei Li , Xiahai Zhuang , Liqin Huang