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Transcription factors are proteins that regulate the expression of genes by binding to specific genomic regions known as Transcription Factor Binding Sites (TFBSs), typically located in the promoter regions of those genes. Accurate…
Accurate prediction of binding sites of a given protein, to which ligands can bind, is a critical step in structure-based computational drug discovery. Recently, Equivariant Graph Neural Networks (GNNs) have emerged as a powerful paradigm…
Dynamic link prediction is a research hot in complex networks area, especially for its wide applications in biology, social network, economy and industry. Compared with static link prediction, dynamic one is much more difficult since…
Link prediction is a cornerstone of the Web ecosystem, powering applications from recommendation and search to knowledge graph completion and collaboration forecasting. However, large-scale networks present unique challenges: they contain…
Transcription factors (TFs) regulate gene expression through complex and co-operative mechanisms. While many TFs act together, the logic underlying TFs binding and their interactions is not fully understood yet. Most current approaches for…
Advanced automated AI techniques allow us to classify protein sequences and discern their biological families and functions. Conventional approaches for classifying these protein families often focus on extracting N-Gram features from the…
Interpretability in Graph Convolutional Networks (GCNs) has been explored to some extent in computer vision in general, yet, in the medical domain, it requires further examination. Moreover, most of the interpretability approaches for GCNs,…
ASD is a complicated neurodevelopmental disorder marked by variation in symptom presentation and neurological underpinnings, making early and objective diagnosis extremely problematic. This paper presents a Graph Convolutional Network (GCN)…
Recently, graph convolutional networks (GCNs) have shown great potential for the task of graph matching. It can integrate graph node feature embedding, node-wise affinity learning and matching optimization together in a unified end-to-end…
Temporal Graph Learning, which aims to model the time-evolving nature of graphs, has gained increasing attention and achieved remarkable performance recently. However, in reality, graph structures are often incomplete and noisy, which…
The combination of the traditional convolutional network (i.e., an auto-encoder) and the graph convolutional network has attracted much attention in clustering, in which the auto-encoder extracts the node attribute feature and the graph…
Noise and inconsistency commonly exist in real-world information networks, due to inherent error-prone nature of human or user privacy concerns. To date, tremendous efforts have been made to advance feature learning from networks, including…
Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regulatory regions on the DNA is a key…
Predicting the effect of amino acid mutations on enzyme thermodynamic stability (DDG) is fundamental to protein engineering and drug design. While recent deep learning approaches have shown promise, they often process sequence and structure…
Graph convolutional network (GCN) is generalization of convolutional neural network (CNN) to work with arbitrarily structured graphs. A binary adjacency matrix is commonly used in training a GCN. Recently, the attention mechanism allows the…
Graph convolutional networks (GCNs) have been very successful in modeling non-Euclidean data structures, like sequences of body skeletons forming actions modeled as spatio-temporal graphs. Most GCN-based action recognition methods use deep…
Graph Neural Networks (GNNs) have demonstrated significant success in learning from graph-structured data but often struggle on heterophilous graphs, where connected nodes differ in features or class labels. This limitation arises from…
For the weakly supervised task of electrocardiogram (ECG) rhythm classification, convolutional neural networks (CNNs) and long short-term memory (LSTM) networks are two increasingly popular classification models. This work investigates…
We present an attention-based spatial graph convolution (AGC) for graph neural networks (GNNs). Existing AGCs focus on only using node-wise features and utilizing one type of attention function when calculating attention weights. Instead,…
Convolutional Neural Networks (CNNs) have become widely adopted for medical image segmentation tasks, demonstrating promising performance. However, the inherent inductive biases in convolutional architectures limit their ability to model…