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Transcription factors are proteins that regulate the expression of genes by binding to specific genomic regions known as Transcription Factor Binding Sites (TFBSs), typically located in the promoter regions of those genes. Accurate…

Machine Learning · Computer Science 2025-02-04 Nimisha Ghosh , Pratik Dutta , Daniele Santoni

Accurate prediction of binding sites of a given protein, to which ligands can bind, is a critical step in structure-based computational drug discovery. Recently, Equivariant Graph Neural Networks (GNNs) have emerged as a powerful paradigm…

Machine Learning · Computer Science 2026-03-23 Animesh , Plaban Kumar Bhowmick , Pralay Mitra

Dynamic link prediction is a research hot in complex networks area, especially for its wide applications in biology, social network, economy and industry. Compared with static link prediction, dynamic one is much more difficult since…

Social and Information Networks · Computer Science 2021-10-05 Jinyin Chen , Xueke Wang , Xuanheng Xu

Link prediction is a cornerstone of the Web ecosystem, powering applications from recommendation and search to knowledge graph completion and collaboration forecasting. However, large-scale networks present unique challenges: they contain…

Social and Information Networks · Computer Science 2026-01-29 Zhejian Yang , Songwei Zhao , Zilin Zhao , Hechang Chen

Transcription factors (TFs) regulate gene expression through complex and co-operative mechanisms. While many TFs act together, the logic underlying TFs binding and their interactions is not fully understood yet. Most current approaches for…

Machine Learning · Computer Science 2026-03-13 Pietro Demurtas , Ferdinando Zanchetta , Giovanni Perini , Rita Fioresi

Advanced automated AI techniques allow us to classify protein sequences and discern their biological families and functions. Conventional approaches for classifying these protein families often focus on extracting N-Gram features from the…

Quantitative Methods · Quantitative Biology 2024-10-24 Bahar Ali , Anwar Shah , Malik Niaz , Musadaq Mansoord , Sami Ullah , Muhammad Adnan

Interpretability in Graph Convolutional Networks (GCNs) has been explored to some extent in computer vision in general, yet, in the medical domain, it requires further examination. Moreover, most of the interpretability approaches for GCNs,…

Computer Vision and Pattern Recognition · Computer Science 2021-03-30 Anees Kazi , Soroush Farghadani , Nassir Navab

ASD is a complicated neurodevelopmental disorder marked by variation in symptom presentation and neurological underpinnings, making early and objective diagnosis extremely problematic. This paper presents a Graph Convolutional Network (GCN)…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Adnan Ferdous Ashrafi , Hasanul Kabir

Recently, graph convolutional networks (GCNs) have shown great potential for the task of graph matching. It can integrate graph node feature embedding, node-wise affinity learning and matching optimization together in a unified end-to-end…

Computer Vision and Pattern Recognition · Computer Science 2019-11-19 Bo Jiang , Pengfei Sun , Jin Tang , Bin Luo

Temporal Graph Learning, which aims to model the time-evolving nature of graphs, has gained increasing attention and achieved remarkable performance recently. However, in reality, graph structures are often incomplete and noisy, which…

Machine Learning · Computer Science 2023-08-16 Haozhen Zhang , Xueting Han , Xi Xiao , Jing Bai

The combination of the traditional convolutional network (i.e., an auto-encoder) and the graph convolutional network has attracted much attention in clustering, in which the auto-encoder extracts the node attribute feature and the graph…

Computer Vision and Pattern Recognition · Computer Science 2021-08-13 Zhihao Peng , Hui Liu , Yuheng Jia , Junhui Hou

Noise and inconsistency commonly exist in real-world information networks, due to inherent error-prone nature of human or user privacy concerns. To date, tremendous efforts have been made to advance feature learning from networks, including…

Machine Learning · Computer Science 2019-12-30 Min Shi , Yufei Tang , Xingquan Zhu , Jianxun Liu

Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regulatory regions on the DNA is a key…

Populations and Evolution · Quantitative Biology 2015-11-09 Murat Tuğrul , Tiago Paixão , Nicholas H. Barton , Gašper Tkačik

Predicting the effect of amino acid mutations on enzyme thermodynamic stability (DDG) is fundamental to protein engineering and drug design. While recent deep learning approaches have shown promise, they often process sequence and structure…

Machine Learning · Computer Science 2025-11-10 Abigail Lin

Graph convolutional network (GCN) is generalization of convolutional neural network (CNN) to work with arbitrarily structured graphs. A binary adjacency matrix is commonly used in training a GCN. Recently, the attention mechanism allows the…

Machine Learning · Statistics 2022-03-03 Chao Shang , Qinqing Liu , Ko-Shin Chen , Jiangwen Sun , Jin Lu , Jinfeng Yi , Jinbo Bi

Graph convolutional networks (GCNs) have been very successful in modeling non-Euclidean data structures, like sequences of body skeletons forming actions modeled as spatio-temporal graphs. Most GCN-based action recognition methods use deep…

Computer Vision and Pattern Recognition · Computer Science 2021-04-26 Negar Heidari , Alexandros Iosifidis

Graph Neural Networks (GNNs) have demonstrated significant success in learning from graph-structured data but often struggle on heterophilous graphs, where connected nodes differ in features or class labels. This limitation arises from…

Machine Learning · Computer Science 2025-09-30 Zhongtian Sun , Anoushka Harit , Alexandra Cristea , Christl A. Donnelly , Pietro Liò

For the weakly supervised task of electrocardiogram (ECG) rhythm classification, convolutional neural networks (CNNs) and long short-term memory (LSTM) networks are two increasingly popular classification models. This work investigates…

Machine Learning · Computer Science 2019-12-03 Nora Vogt

We present an attention-based spatial graph convolution (AGC) for graph neural networks (GNNs). Existing AGCs focus on only using node-wise features and utilizing one type of attention function when calculating attention weights. Instead,…

Computer Vision and Pattern Recognition · Computer Science 2023-03-06 Yang Li , Yuichi Tanaka

Convolutional Neural Networks (CNNs) have become widely adopted for medical image segmentation tasks, demonstrating promising performance. However, the inherent inductive biases in convolutional architectures limit their ability to model…

Computer Vision and Pattern Recognition · Computer Science 2024-05-03 Ziya Ata Yazıcı , İlkay Öksüz , Hazım Kemal Ekenel
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