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Clinical MRI frequently acquires anisotropic volumes with high in-plane resolution and low through-plane resolution to reduce acquisition time. Multiple orientations are therefore acquired to provide complementary anatomical information.…
The most sophisticated existing methods to generate 3D isotropic super-resolution (SR) from non-isotropic electron microscopy (EM) are based on learned dictionaries. Unfortunately, none of the existing methods generate practically…
Computed tomography (CT) is one of the most widely used non-invasive imaging modalities for medical diagnosis. In clinical practice, CT images are usually acquired with large slice thicknesses due to the high cost of memory storage and…
In motion-robust magnetic resonance imaging (MRI), slice-to-volume reconstruction is critical for recovering anatomically consistent 3D brain volumes from 2D slices, especially under accelerated acquisitions or patient motion. However, this…
Anisotropic low-resolution (LR) magnetic resonance (MR) images are fast to obtain but hinder automated processing. We propose to use denoising diffusion probabilistic models (DDPMs) to super-resolve these 2D-acquired LR MR slices. This…
The inability to acquire clean high-resolution (HR) electron microscopy (EM) images over a large brain tissue volume hampers many neuroscience studies. To address this challenge, we propose a deep-learning-based image super-resolution (SR)…
Magnetic resonance imaging (MRI) super-resolution (SR) methods that computationally enhance low-resolution acquisitions to approximate high-resolution quality offer a compelling alternative to expensive high-field scanners. In this work we…
Computed tomography (CT) samples with pathological annotations are difficult to obtain. As a result, the computer-aided diagnosis (CAD) algorithms are trained on small datasets (e.g., LIDC-IDRI with 1,018 samples), limiting their accuracies…
Neuropathological analyses benefit from spatially precise volumetric reconstructions that enhance anatomical delineation and improve morphometric accuracy. Our prior work has shown the feasibility of reconstructing 3D brain volumes from 2D…
Large-scale volumetric medical images with annotation are rare, costly, and time prohibitive to acquire. Self-supervised learning (SSL) offers a promising pre-training and feature extraction solution for many downstream tasks, as it only…
Although high resolution isotropic 3D medical images are desired in clinical practice, their acquisition is not always feasible. Instead, lower resolution images are upsampled to higher resolution using conventional interpolation methods.…
Volumetric imaging by fluorescence microscopy is often limited by anisotropic spatial resolution from inferior axial resolution compared to the lateral resolution. To address this problem, here we present a deep-learning-enabled…
To date, the most common approach for radiology deep learning pipelines is the use of end-to-end 3D networks based on models pre-trained on other tasks, followed by fine-tuning on the task at hand. In contrast, adjacent medical fields such…
Multi-contrast MRI methods acquire multiple images with different contrast weightings, which are used for the differentiation of the tissue types or quantitative mapping. However, the scan time needed to acquire multiple contrasts is…
Magnetic Resonance Imaging (MRI) represents an important diagnostic modality; however, its inherently slow acquisition process poses challenges in obtaining fully-sampled $k$-space data under motion. In the absence of fully-sampled…
High-resolution fMRI provides a window into the brain's mesoscale organization. Yet, higher spatial resolution increases scan times, to compensate for the low signal and contrast-to-noise ratio. This work introduces a deep learning-based 3D…
Deep learning-based dMRI super-resolution methods can effectively enhance image resolution by leveraging the learning capabilities of neural networks on large datasets. However, these methods tend to learn a fixed scale mapping between…
Volumetric biomedical microscopy has the potential to increase the diagnostic information extracted from clinical tissue specimens and improve the diagnostic accuracy of both human pathologists and computational pathology models.…
In Magnetic Resonance Imaging (MRI), image acquisitions are often undersampled in the measurement domain to accelerate the scanning process, at the expense of image quality. However, image quality is a crucial factor that influences the…
Automatic and accurate tumor segmentation on medical images is in high demand to assist physicians with diagnosis and treatment. However, it is difficult to obtain massive amounts of annotated training data required by the deep-learning…