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Object segmentation is an important step in the workflow of computational pathology. Deep learning based models generally require large amount of labeled data for precise and reliable prediction. However, collecting labeled data is…

Computer Vision and Pattern Recognition · Computer Science 2020-07-08 Navid Alemi Koohbanani , Mostafa Jahanifar , Neda Zamani Tajadin , Nasir Rajpoot

Diffusion models have been demonstrated as strong priors for solving general inverse problems. Most existing Diffusion model-based Inverse Problem Solvers (DIS) employ a plug-and-play approach to guide the sampling trajectory with either…

Computer Vision and Pattern Recognition · Computer Science 2024-07-18 Jiankun Zhao , Bowen Song , Liyue Shen

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Image segmentation methods are usually trained with pixel-level annotations, which require significant human effort to collect. The most common solution to address this constraint is to implement weakly-supervised pipelines trained with…

Computer Vision and Pattern Recognition · Computer Science 2020-08-26 Miriam Bellver , Amaia Salvador , Jordi Torres , Xavier Giro-i-Nieto

Class-agnostic counting (CAC) aims to estimate the number of objects in images without being restricted to predefined categories. However, while current exemplar-based CAC methods offer flexibility at inference time, they still rely heavily…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Giacomo Pacini , Lorenzo Bianchi , Luca Ciampi , Nicola Messina , Giuseppe Amato , Fabrizio Falchi

Segmenting tumors in histological images is vital for cancer diagnosis. While fully supervised models excel with pixel-level annotations, creating such annotations is labor-intensive and costly. Accurate histopathology image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Yinsheng He , Xingyu Li , Roger J. Zemp

Nuclei segmentation is a fundamental prerequisite in the digital pathology workflow. The development of automated methods for nuclei segmentation enables quantitative analysis of the wide existence and large variances in nuclei morphometry…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Yi Lin , Zeyu Wang , Dong Zhang , Kwang-Ting Cheng , Hao Chen

Instance segmentation for unlabeled imaging modalities is a challenging but essential task as collecting expert annotation can be expensive and time-consuming. Existing works segment a new modality by either deploying a pre-trained model…

Computer Vision and Pattern Recognition · Computer Science 2022-04-08 Leander Lauenburg , Zudi Lin , Ruihan Zhang , Márcia dos Santos , Siyu Huang , Ignacio Arganda-Carreras , Edward S. Boyden , Hanspeter Pfister , Donglai Wei

Accurate cell segmentation is critical for biological and medical imaging studies. Although recent deep learning models have advanced this task, most methods are limited to generic cell segmentation, lacking the ability to differentiate…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Bisheng Wang , Jaime S. Cardoso , Lin Wu

Although instance segmentation methods have improved considerably, the dominant paradigm is to rely on fully-annotated training images, which are tedious to obtain. To alleviate this reliance, and boost results, semi-supervised approaches…

Computer Vision and Pattern Recognition · Computer Science 2023-12-15 Tariq Berrada , Camille Couprie , Karteek Alahari , Jakob Verbeek

We present a high-performance method that can achieve mask-level instance segmentation with only bounding-box annotations for training. While this setting has been studied in the literature, here we show significantly stronger performance…

Computer Vision and Pattern Recognition · Computer Science 2020-12-07 Zhi Tian , Chunhua Shen , Xinlong Wang , Hao Chen

Camouflaged Object Segmentation (COS) faces significant challenges due to the scarcity of annotated data, where meticulous pixel-level annotation is both labor-intensive and costly, primarily due to the intricate object-background…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Cheng Lei , Jie Fan , Xinran Li , Tianzhu Xiang , Ao Li , Ce Zhu , Le Zhang

Segmentation of objects in microscopy images is required for many biomedical applications. We introduce object-centric embeddings (OCEs), which embed image patches such that the spatial offsets between patches cropped from the same object…

Machine Learning · Computer Science 2023-10-13 Steffen Wolf , Manan Lalit , Henry Westmacott , Katie McDole , Jan Funke

Background: The quantitative analysis of microscope videos often requires instance segmentation and tracking of cellular and subcellular objects. The traditional method consists of two stages: (1) performing instance object segmentation of…

Image and Video Processing · Electrical Eng. & Systems 2021-05-25 Quan Liu , Isabella M. Gaeta , Mengyang Zhao , Ruining Deng , Aadarsh Jha , Bryan A. Millis , Anita Mahadevan-Jansen , Matthew J. Tyska , Yuankai Huo

Human-annotated labels are often prone to noise, and the presence of such noise will degrade the performance of the resulting deep neural network (DNN) models. Much of the literature (with several recent exceptions) of learning with noisy…

Machine Learning · Computer Science 2021-03-24 Hao Cheng , Zhaowei Zhu , Xingyu Li , Yifei Gong , Xing Sun , Yang Liu

Purpose: Non-invasive grading of prostate cancer (PCa) from micro-ultrasound (micro-US) could expedite triage and guide biopsies toward the most aggressive regions, yet current models struggle to infer tissue micro-structure at coarse…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Emma Willis , Tarek Elghareb , Paul F. R. Wilson , Minh Nguyen Nhat To , Mohammad Mahdi Abootorabi , Amoon Jamzad , Brian Wodlinger , Parvin Mousavi , Purang Abolmaesumi

Accurate and efficient registration of whole slide images (WSIs) is essential for high-resolution, nuclei-level analysis in multi-stained tissue slides. We propose a novel coarse-to-fine framework CORE for accurate nuclei-level registration…

Obtaining a large amount of labeled data in medical imaging is laborious and time-consuming, especially for histopathology. However, it is much easier and cheaper to get unlabeled data from whole-slide images (WSIs). Semi-supervised…

Image and Video Processing · Electrical Eng. & Systems 2020-08-13 Zeyu Gao , Pargorn Puttapirat , Jiangbo Shi , Chen Li

Weakly supervised instance segmentation (WSIS) using only image-level labels is a challenging task due to the difficulty of aligning coarse annotations with the finer task. However, with the advancement of deep neural networks (DNNs), WSIS…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Zecheng Li , Zening Zeng , Yuqi Liang , Jin-Gang Yu

Instance segmentation is an important computer vision problem which remains challenging despite impressive recent advances due to deep learning-based methods. Given sufficient training data, fully supervised methods can yield excellent…

Computer Vision and Pattern Recognition · Computer Science 2023-03-22 Paul Hilt , Maedeh Zarvandi , Edgar Kaziakhmedov , Sourabh Bhide , Maria Leptin , Constantin Pape , Anna Kreshuk