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Agent-based simulation is an indispensable paradigm for studying complex systems. These systems can comprise billions of agents, requiring the computing resources of multiple servers to simulate. Unfortunately, the state-of-the-art…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-30 Lukas Breitwieser , Ahmad Hesam , Abdullah Giray Yağlıkçı , Mohammad Sadrosadati , Fons Rademakers , Onur Mutlu

Motivation: Agent-based modeling is an indispensable tool for studying complex biological systems. However, existing simulators do not always take full advantage of modern hardware and often have a field-specific software design. Results:…

Agent-based modeling plays an essential role in gaining insights into biology, sociology, economics, and other fields. However, many existing agent-based simulation platforms are not suitable for large-scale studies due to the low…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-04-25 Lukas Breitwieser , Ahmad Hesam , Fons Rademakers , Juan Gómez Luna , Onur Mutlu

Researchers in biology are faced with the tough challenge of developing high-performance computer simulations of their increasingly complex agent-based models. BioDynaMo is an open-source agent-based simulation platform that aims to…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-06-29 Ahmad Hesam , Lukas Breitwieser , Fons Rademakers , Zaid Al-Ars

Molecular dynamics (MD) simulation is a powerful tool for studying biomolecular structural changes, molecular recognition, transmembrane transport, and functional mechanisms. However, its practical bottleneck lies not only in software…

Quantitative Methods · Quantitative Biology 2026-04-22 Zhenyu Ma , Chunyi Yang , Yuyang Song , Jingyi Zhu , Letian Yang , Limei Xu , Min Xiao , Xukai Jiang

Understanding human behavior in built environments is critical for designing functional, user centered urban spaces. Traditional approaches, such as manual observations, surveys, and simplified simulations, often fail to capture the…

Artificial Intelligence · Computer Science 2024-12-30 Ariel Noyman , Kai Hu , Kent Larson

Simulating and predicting planetary-scale techno-social systems poses heavy computational and modeling challenges. The DARPA SocialSim program set the challenge to model the evolution of GitHub, a large collaborative software-development…

Recent advances in large language models (LLMs) have opened new avenues for applying multi-agent systems in very large-scale simulations. However, there remain several challenges when conducting multi-agent simulations with existing…

Multiagent Systems · Computer Science 2024-10-29 Xuchen Pan , Dawei Gao , Yuexiang Xie , Yushuo Chen , Zhewei Wei , Yaliang Li , Bolin Ding , Ji-Rong Wen , Jingren Zhou

In this work, we introduce MedAgentSim, an open-source simulated clinical environment with doctor, patient, and measurement agents designed to evaluate and enhance LLM performance in dynamic diagnostic settings. Unlike prior approaches, our…

Computation and Language · Computer Science 2025-10-02 Mohammad Almansoori , Komal Kumar , Hisham Cholakkal

Agent-based modeling and network science have been used extensively to advance our understanding of emergent collective behavior in systems that are composed of a large number of simple interacting individuals or agents. With the increasing…

Multiagent Systems · Computer Science 2019-03-14 Marcos Cardinot , Colm O'Riordan , Josephine Griffith , Matjaž Perc

Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly…

Quantitative Methods · Quantitative Biology 2025-04-17 Kerri-Ann Norton , Daniel Bergman , Harsh Vardhan Jain , Trachette Jackson

Human-like Agents with diverse and dynamic personalities could serve as an essential design probe in the process of user-centered design, thereby enabling designers to enhance the user experience of interactive applications. In this…

Human-Computer Interaction · Computer Science 2024-06-18 Jiale Li , Jiayang Li , Jiahao Chen , Yifan Li , Shijie Wang , Hugo Zhou , Minjun Ye , Yunsheng Su

Current AI agent frameworks commit early to a single interaction protocol, a fixed tool integration strategy, and static user models, limiting their deployment across diverse interaction paradigms. To address these constraints, we introduce…

Artificial Intelligence · Computer Science 2026-03-25 Alfred Shen , Aaron Shen

We present Megaverse, a new 3D simulation platform for reinforcement learning and embodied AI research. The efficient design of our engine enables physics-based simulation with high-dimensional egocentric observations at more than 1,000,000…

Machine Learning · Computer Science 2021-07-22 Aleksei Petrenko , Erik Wijmans , Brennan Shacklett , Vladlen Koltun

We introduce GenAgent, unifying visual understanding and generation through an agentic multimodal model. Unlike unified models that face expensive training costs and understanding-generation trade-offs, GenAgent decouples these capabilities…

Computer Vision and Pattern Recognition · Computer Science 2026-01-29 Kaixun Jiang , Yuzheng Wang , Junjie Zhou , Pandeng Li , Zhihang Liu , Chen-Wei Xie , Zhaoyu Chen , Yun Zheng , Wenqiang Zhang

Creating end-to-end bioinformatics workflows requires diverse domain expertise, which poses challenges for both junior and senior researchers as it demands a deep understanding of both genomics concepts and computational techniques. While…

Due to decelerating gains in single-core CPU performance, computationally expensive simulations are increasingly executed on highly parallel hardware platforms. Agent-based simulations, where simulated entities act with a certain degree of…

Multiagent Systems · Computer Science 2018-07-04 Jiajian Xiao , Philipp Andelfinger , David Eckhoff , Wentong Cai , Alois Knoll

Multi-agent large language model simulations have the potential to model complex human behaviors and interactions. If the mechanics are set up properly, unanticipated and valuable social dynamics can surface. However, it is challenging to…

Multiagent Systems · Computer Science 2026-04-22 Jenny Ma , Riya Sahni , Karthik Sreedhar , Lydia B. Chilton

Agent-based modeling and simulation tools provide a mature platform for development of complex simulations. They however, have not been applied much in the domain of mainstream modeling and simulation of computer networks. In this article,…

Networking and Internet Architecture · Computer Science 2017-08-07 Muaz A. Niazi , Amir Hussain

We introduce a new software toolbox for agent-based simulation. Facilitating rapid prototyping by offering a user-friendly Python API, its core rests on an efficient C++ implementation to support simulation of large-scale multi-agent…

Computational Finance · Quantitative Finance 2022-09-22 Peter Belcak , Jan-Peter Calliess , Stefan Zohren
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