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Recent efforts in Machine Learning (ML) interpretability have focused on creating methods for explaining black-box ML models. However, these methods rely on the assumption that simple approximations, such as linear models or decision-trees,…

Machine Learning · Computer Science 2019-06-13 Owen Lahav , Nicholas Mastronarde , Mihaela van der Schaar

In pharmaceutical R&D, predicting the efficacy of a pharmaceutical in treating a particular disease prior to clinical testing or any real-world use has been challenging. In this paper, we propose a flexible and modular machine…

Machine Learning · Computer Science 2025-09-10 Adrien Couetoux , Thomas Devenyns , Lise Diagne , David Champagne , Pierre-Yves Mousset , Chris Anagnostopoulos

Recent methodological developments have introduced new black-box approaches to better estimate heterogeneous treatment effects; however, these methods fall short of providing interpretable characterizations of the underlying individuals who…

Methodology · Statistics 2025-08-19 Melody Huang , Tiffany M. Tang , Ana M. Kenney

Deep learning methods for ophthalmic diagnosis have shown considerable success in tasks like segmentation and classification. However, their widespread application is limited due to the models being opaque and vulnerable to making a wrong…

Image and Video Processing · Electrical Eng. & Systems 2021-01-29 Amitojdeep Singh , Sourya Sengupta , Mohammed Abdul Rasheed , Varadharajan Jayakumar , Vasudevan Lakshminarayanan

Since 2006, deep learning (DL) has become a rapidly growing research direction, redefining state-of-the-art performances in a wide range of areas such as object recognition, image segmentation, speech recognition and machine translation. In…

Machine Learning · Computer Science 2016-12-23 Rui Zhao , Ruqiang Yan , Zhenghua Chen , Kezhi Mao , Peng Wang , Robert X. Gao

Correctly assessing the malignancy of breast lesions identified during ultrasound examinations is crucial for effective clinical decision-making. However, the current "golden standard" relies on manual BI-RADS scoring by clinicians, often…

Machine Learning · Computer Science 2024-08-29 Alek Fröhlich , Thiago Ramos , Gustavo Cabello , Isabela Buzatto , Rafael Izbicki , Daniel Tiezzi

Metaphor detection (MD) suffers from limited training data. In this paper, we started with a linguistic rule called Metaphor Identification Procedure and then proposed a novel multi-task learning framework to transfer knowledge in basic…

Computation and Language · Computer Science 2023-05-29 Shenglong Zhang , Ying Liu

Deep learning assisted digital pathology has the potential to impact clinical practice in significant ways. In recent studies, deep neural network (DNN) enabled analysis outperforms human pathologists. Increasing sizes and complexity of the…

Image and Video Processing · Electrical Eng. & Systems 2024-06-04 Haowen Zhou , Steven , Lin , Mark Watson , Cory T. Bernadt , Oumeng Zhang , Ramaswamy Govindan , Richard J. Cote , Changhuei Yang

This research aims to improve dietetic-nutritional treatment using state-of-the-art RGB-D sensors and virtual reality (VR) technology. Recent studies show that adherence to treatment can be improved using multimedia technologies. However,…

Computer Vision and Pattern Recognition · Computer Science 2020-07-03 Andrés Fuster-Guilló , Jorge Azorín-López , Marcelo Saval-Calvo , Juan Miguel Castillo-Zaragoza , Nahuel Garcia-DUrso , Robert B Fisher

Effective management of Type 1 Diabetes requires continuous glucose monitoring and precise insulin adjustments to prevent hyperglycemia and hypoglycemia. With the growing adoption of wearable glucose monitors and mobile health applications,…

Machine Learning · Computer Science 2026-01-22 Giorgia Rigamonti , Mirko Paolo Barbato , Davide Marelli , Paolo Napoletano

The key to success in machine learning (ML) is the use of effective data representations. Traditionally, data representations were hand-crafted. Recently it has been demonstrated that, given sufficient data, deep neural networks can learn…

Machine Learning · Computer Science 2018-11-09 Ivan Olier , Oghenejokpeme I. Orhobor , Joaquin Vanschoren , Ross D. King

In healthcare there is a pursuit for employing interpretable algorithms to assist healthcare professionals in several decision scenarios. Following the Predictive, Descriptive and Relevant (PDR) framework, the definition of interpretable…

In critical decision support systems based on medical imaging, the reliability of AI-assisted decision-making is as relevant as predictive accuracy. Although deep learning models have demonstrated significant accuracy, they frequently…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Hua Xu , Julián D. Arias-Londoño , Juan I. Godino-Llorente

Image-based precision medicine aims to personalize treatment decisions based on an individual's unique imaging features so as to improve their clinical outcome. Machine learning frameworks that integrate uncertainty estimation as part of…

Machine Learning · Computer Science 2023-08-11 Joshua Durso-Finley , Jean-Pierre Falet , Raghav Mehta , Douglas L. Arnold , Nick Pawlowski , Tal Arbel

Background: Mental stress and its consequent mental disorders (MDs) are significant public health issues. With the advent of machine learning (ML), there's potential to harness computational techniques for better understanding and…

Parkinson's Disease (PD) medication management presents unique challenges due to heterogeneous disease progression and treatment response. Neurologists must balance symptom control with optimal dopaminergic dosing based on functional…

Machine Learning · Computer Science 2025-08-15 Ricardo Diaz-Rincon , Muxuan Liang , Adolfo Ramirez-Zamora , Benjamin Shickel

Causal inference is capable of estimating the treatment effect (i.e., the causal effect of treatment on the outcome) to benefit the decision making in various domains. One fundamental challenge in this research is that the treatment…

Machine Learning · Computer Science 2021-12-28 Qian Li , Zhichao Wang , Shaowu Liu , Gang Li , Guandong Xu

Explainability is key to enhancing artificial intelligence's trustworthiness in medicine. However, several issues remain concerning the actual benefit of explainable models for clinical decision-making. Firstly, there is a lack of consensus…

Image and Video Processing · Electrical Eng. & Systems 2023-12-18 Kazuma Kobayashi , Yasuyuki Takamizawa , Mototaka Miyake , Sono Ito , Lin Gu , Tatsuya Nakatsuka , Yu Akagi , Tatsuya Harada , Yukihide Kanemitsu , Ryuji Hamamoto

Estimating causal effects of continuous treatments is a common problem in practice, for example, in studying average dose-response functions. Classical analyses typically assume that all confounders are fully observed, whereas in real-world…

Statistics Theory · Mathematics 2026-04-14 Shuyuan Chen , Peng Zhang , Yifan Cui

Recent advancements in the acquisition of various brain data sources have created new opportunities for integrating multimodal brain data to assist in early detection of complex brain disorders. However, current data integration approaches…

Image and Video Processing · Electrical Eng. & Systems 2023-05-26 Reza Shirkavand , Liang Zhan , Heng Huang , Li Shen , Paul M. Thompson