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Antibody binding site prediction plays a pivotal role in computational immunology and therapeutic antibody design. Existing sequence or structure methods rely on single-view features and fail to identify antibody-specific binding sites on…

Machine Learning · Computer Science 2025-09-12 Hongzong Li , Jiahao Ma , Zhanpeng Shi , Rui Xiao , Fanming Jin , Ye-Fan Hu , Hangjun Che , Jian-Dong Huang

We study multimodal survival analysis integrating clinical text, tabular covariates, and genomic profiles using locally deployable large language models (LLMs). As many institutions face tight computational and privacy constraints, this…

Machine Learning · Computer Science 2026-03-24 Moritz Gögl , Christopher Yau

Survival analysis is a task to model the time until an event of interest occurs, widely used in clinical and biomedical research. A key challenge is to model patient heterogeneity while also adapting risk predictions to both individual…

Machine Learning · Computer Science 2025-10-31 Hyeonjun Lee , Hyungseob Shin , Gunhee Nam , Hyeonsoo Lee

Accurately predicting the survival rate of cancer patients is crucial for aiding clinicians in planning appropriate treatment, reducing cancer-related medical expenses, and significantly enhancing patients' quality of life. Multimodal…

Computer Vision and Pattern Recognition · Computer Science 2024-03-15 Liangrui Pan , Yijun Peng , Yan Li , Xiang Wang , Wenjuan Liu , Liwen Xu , Qingchun Liang , Shaoliang Peng

Although current prompt learning methods have successfully been designed to effectively reuse the large pre-trained models without fine-tuning their large number of parameters, they still have limitations to be addressed, i.e., without…

Machine Learning · Computer Science 2023-12-05 Zongqian Wu , Yujing Liu , Mengmeng Zhan , Jialie Shen , Ping Hu , Xiaofeng Zhu

Existing Transformer-based RGBT tracking methods either use cross-attention to fuse the two modalities, or use self-attention and cross-attention to model both modality-specific and modality-sharing information. However, the significant…

Computer Vision and Pattern Recognition · Computer Science 2023-04-25 Yabin Zhu , Chenglong Li , Xiao Wang , Jin Tang , Zhixiang Huang

When oncologists estimate cancer patient survival, they rely on multimodal data. Even though some multimodal deep learning methods have been proposed in the literature, the majority rely on having two or more independent networks that share…

Image and Video Processing · Electrical Eng. & Systems 2022-09-13 Numan Saeed , Ikboljon Sobirov , Roba Al Majzoub , Mohammad Yaqub

Benefiting from the powerful expressive capability of graphs, graph-based approaches have achieved impressive performance in various biomedical applications. Most existing methods tend to define the adjacency matrix among samples manually…

Machine Learning · Computer Science 2021-07-02 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yao Zhao

Existed pre-training methods either focus on single-modal tasks or multi-modal tasks, and cannot effectively adapt to each other. They can only utilize single-modal data (i.e. text or image) or limited multi-modal data (i.e. image-text…

Computation and Language · Computer Science 2022-03-15 Wei Li , Can Gao , Guocheng Niu , Xinyan Xiao , Hao Liu , Jiachen Liu , Hua Wu , Haifeng Wang

Managing fluid balance in dialysis patients is crucial, as improper management can lead to severe complications. In this paper, we propose a multimodal approach that integrates visual features from lung ultrasound images with clinical data…

Image and Video Processing · Electrical Eng. & Systems 2024-10-04 Tianqi Yang , Nantheera Anantrasirichai , Oktay Karakuş , Marco Allinovi , Alin Achim

Automatic emotion recognition is an active research topic with wide range of applications. Due to the high manual annotation cost and inevitable label ambiguity, the development of emotion recognition dataset is limited in both scale and…

Audio and Speech Processing · Electrical Eng. & Systems 2020-09-08 Jingjun Liang , Ruichen Li , Qin Jin

Accurate molecular property prediction (MPP) is a critical step in modern drug development. However, the scarcity of experimental validation data poses a significant challenge to AI-driven research paradigms. Under few-shot learning…

Machine Learning · Computer Science 2025-05-20 Yifan Dai , Xuanbai Ren , Tengfei Ma , Qipeng Yan , Yiping Liu , Yuansheng Liu , Xiangxiang Zeng

Self-supervised learning is an efficient pre-training method for medical image analysis. However, current research is mostly confined to specific-modality data pre-training, consuming considerable time and resources without achieving…

Computer Vision and Pattern Recognition · Computer Science 2023-12-01 Yiwen Ye , Yutong Xie , Jianpeng Zhang , Ziyang Chen , Qi Wu , Yong Xia

Learning multimodal representations from medical images and other data sources can provide richer information for decision-making. While various multimodal models have been developed for this, they overlook learning features that are both…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Boyu Chen , Weiye Bao , Junjie Liu , Michael Shen , Bo Peng , Paul Taylor , Zhu Li , Mengyue Yang

Pre-trained vision-language models (VLMs) have shown remarkable generalization capabilities via prompting, which leverages VLMs as knowledge bases to extract information beneficial for downstream tasks. However, existing methods primarily…

Computer Vision and Pattern Recognition · Computer Science 2024-04-25 Xiaoyu Qiu , Hao Feng , Yuechen Wang , Wengang Zhou , Houqiang Li

We present a framework for optimizing prompts in vision-language models to elicit multimodal reasoning without model retraining. Using an evolutionary algorithm to guide prompt updates downstream of visual tasks, our approach improves upon…

Computation and Language · Computer Science 2025-04-01 Sid Bharthulwar , John Rho , Katrina Brown

The integrative analysis of histopathological images and genomic data has received increasing attention for survival prediction of human cancers. However, the existing studies always hold the assumption that full modalities are available.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Junjie Zhou , Jiao Tang , Yingli Zuo , Peng Wan , Daoqiang Zhang , Wei Shao

Risk stratification is a key tool in clinical decision-making, yet current approaches often fail to translate sophisticated survival analysis into actionable clinical criteria. We present a novel method for unsupervised machine learning…

The diagnosis and prognosis of cancer are typically based on multi-modal clinical data, including histology images and genomic data, due to the complex pathogenesis and high heterogeneity. Despite the advancements in digital pathology and…

Quantitative Methods · Quantitative Biology 2024-04-15 Zeyu Zhang , Yuanshen Zhao , Jingxian Duan , Yaou Liu , Hairong Zheng , Dong Liang , Zhenyu Zhang , Zhi-Cheng Li

Due to the severe lack of labeled data, existing methods of medical visual question answering usually rely on transfer learning to obtain effective image feature representation and use cross-modal fusion of visual and linguistic features to…

Multimedia · Computer Science 2021-05-04 Haifan Gong , Guanqi Chen , Sishuo Liu , Yizhou Yu , Guanbin Li