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Physics-Informed Neural Networks (PINNs) have become a popular way to infer interpretable interaction parameters from noisy microbial time series, but practitioners face many tunable design choices (loss weights, regularisers, scaling,…

Quantitative Methods · Quantitative Biology 2025-09-03 Pedro Fontanarrosa , Chris P Barnes

Digital twin technology, when combined with physics-informed machine learning with simulation results of Aspen, offers transformative capabilities for industrial process monitoring, control, and optimization. In this work, the proposed…

Machine Learning · Computer Science 2026-03-27 Debadutta Patra , Ayush Bardhan Tripathy , Soumya Ranjan Sahu , Sucheta Panda

Physics-informed neural networks (PINNs) are numerical solvers that embed all the physical information of a system into the loss function of a neural network. In this way the learned solution accounts for data (if available), the governing…

Computational Physics · Physics 2025-07-30 Andrés Martínez-Esteban , Pablo Calvo-Barlés , Luis Martín-Moreno , Sergio G Rodrigo

Physics-informed neural networks (PINNs) are neural networks that embed the laws of dynamical systems modeled by differential equations into their loss function as constraints. In this work, we present a PINN framework applied to oncology.…

Machine Learning · Computer Science 2025-10-16 Kayode Olumoyin , Katarzyna Rejniak

Physics-Informed Neural Networks (PINNs) have recently emerged as a novel approach to simulate complex physical systems on the basis of both data observations and physical models. In this work, we investigate the use of PINNs for various…

Analysis of PDEs · Mathematics 2024-03-27 Guillaume Coulaud , Maxime Le , Régis Duvigneau

We introduce an optimized physics-informed neural network (PINN) trained to solve the problem of identifying and characterizing a surface breaking crack in a metal plate. PINNs are neural networks that can combine data and physics in the…

Machine Learning · Computer Science 2020-05-09 Khemraj Shukla , Patricio Clark Di Leoni , James Blackshire , Daniel Sparkman , George Em Karniadakis

We enhance machine learning algorithms for learning model parameters in complex systems represented by ordinary differential equations (ODEs) with domain decomposition methods. The study evaluates the performance of two approaches, namely…

Numerical Analysis · Mathematics 2024-10-03 Tirtho S. Saha , Alexander Heinlein , Cordula Reisch

Inferring biophysical parameters and hidden state variables from partial and noisy observations is a fundamental challenge in computational neuroscience. This problem is particularly difficult for fast - slow spiking and bursting models,…

Neural and Evolutionary Computing · Computer Science 2026-03-11 Changliang Wei , Yangyang Wang , Xueyu Zhu

In this work, we present the physics-informed neural network (PINN) model applied particularly to dynamic problems in solid mechanics. We focus on forward and inverse problems. Particularly, we show how a PINN model can be used efficiently…

Neural and Evolutionary Computing · Computer Science 2025-12-16 Vijay Kag , Venkatesh Gopinath

In this work, a physics-informed neural networks (PINNs) based algorithm is used for simulation of nonlinear 1D and 2D Burgers' type models. This scheme relies on a neural network built to approximate the problem solution and use a trial…

Machine Learning · Computer Science 2025-06-17 Ajeet Singh , Ram Jiwari , Vikram , Ujjwal Saini

Accurate dynamical modeling is essential for simulation and control of embodied systems, yet first-principles models of electromechanical systems often fail to capture complex dissipative effects such as joint friction, stray losses, and…

Machine Learning · Computer Science 2026-04-21 Youyuan Long , Gokhan Solak , Arash Ajoudani

Physics-informed neural networks (PINNs) impose known physical laws into the learning of deep neural networks, making sure they respect the physics of the process while decreasing the demand of labeled data. For systems represented by…

Physics-Informed Neural Networks (PINNs) integrate machine learning with differential equations to solve forward and inverse problems while ensuring that predictions adhere to physical laws. Physiologically based pharmacokinetic (PBPK)…

This work focuses on understanding the minimum eradication time for the controlled Susceptible-Infectious-Recovered (SIR) model in the time-homogeneous setting, where the infection and recovery rates are constant. The eradication time is…

Optimization and Control · Mathematics 2026-01-27 Minseok Kim , Yeongjong Kim , Yeoneung Kim

This study develops and analyzes a stochastic differential equation (SDE) model for the dynamics of hepatitis B virus (HBV) infection. While deterministic frameworks have yielded important insights into viral behavior, they cannot…

Dynamical Systems · Mathematics 2025-10-03 Abdallah Alsammani

Deep neural networks (DNNs) are becoming more prevalent in important safety-critical applications, where reliability in the prediction is paramount. Despite their exceptional prediction capabilities, current DNNs do not have an implicit…

Machine Learning · Computer Science 2021-05-14 David Betancourt , Rafi Muhanna

We introduce the Dynamic Influence Network (DIN), a novel visual analytics technique for representing and analyzing rule-based models of protein-protein interaction networks. Rule-based modeling has proved instrumental in developing…

Graphics · Computer Science 2017-11-06 Angus G. Forbes , Andrew Burks , Kristine Lee , Xing Li , Pierre Boutillier , Jean Krivine , Walter Fontana

The Hubble function characterizes a given Friedmann-Robertson-Walker spacetime and can be related to the densities of the cosmological fluids and their equations of state. We show how physics-informed neural networks (PINNs) emulate this…

Cosmology and Nongalactic Astrophysics · Physics 2024-03-25 Lennart Röver , Björn Malte Schäfer , Tilman Plehn

Physics-Informed Neural Network (PINN) is a novel multi-task learning framework useful for solving physical problems modeled using differential equations (DEs) by integrating the knowledge of physics and known constraints into the…

Machine Learning · Computer Science 2024-09-18 Shivprasad Kathane , Shyamprasad Karagadde

Physics-informed neural networks (PINNs) represent a significant advancement in scientific machine learning by integrating fundamental physical laws into their architecture through loss functions. PINNs have been successfully applied to…

Machine Learning · Computer Science 2024-07-16 Wei Zhou , Y. F. Xu
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