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As machine learning (ML) continue to be integrated into healthcare systems that affect clinical decision making, new strategies will need to be incorporated in order to effectively detect and evaluate subgroup disparities to ensure…

Machine Learning · Computer Science 2021-07-19 Charles Lu , Andreanne Lemay , Katharina Hoebel , Jayashree Kalpathy-Cramer

Model-based recursive partitioning (MOB) can be used to identify subgroups with differing treatment effects. The detection rate of treatment-by-covariate interactions and the accuracy of identified subgroups using MOB depend strongly on the…

Applications · Statistics 2022-09-07 Cynthia Huber , Norbert Benda , Tim Friede

Detection of easily missed hidden patterns with fast processing power makes machine learning (ML) indispensable to today's healthcare system. Though many ML applications have already been discovered and many are still under investigation,…

Machine Learning · Computer Science 2023-07-27 Mrinmoy Roy , Sarwar J. Minar , Porarthi Dhar , A T M Omor Faruq

Although deep learning (DL) models have shown great success in many medical image analysis tasks, deployment of the resulting models into real clinical contexts requires: (1) that they exhibit robustness and fairness across different…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Raghav Mehta , Changjian Shui , Tal Arbel

Medical image analysis models can exhibit performance disparities across patient subgroups, threatening clinical safety and fairness. Existing methods typically address this issue by optimizing accuracy and fairness metrics for visible…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Milad Masroor , Cuong Nguyen , Kevin Wells , Gustavo Carneiro

Unequal representation of demographic groups in training data poses challenges to model generalisation across populations. Standard practice assumes that balancing subgroup representation optimises performance. However, recent empirical…

Machine Learning · Computer Science 2025-12-11 Anissa Alloula , Charles Jones , Zuzanna Wakefield-Skorniewska , Francesco Quinzan , Bartłomiej Papież

Automated mammography screening plays an important role in early breast cancer detection. However, current machine learning models, developed on some training datasets, may exhibit performance degradation and bias when deployed in…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Amit Kumar Kundu , Florence X. Doo , Vaishnavi Patil , Amitabh Varshney , Joseph Jaja

Identifying patient subgroups with different treatment responses is an important task to inform medical recommendations, guidelines, and the design of future clinical trials. Existing approaches for treatment effect estimation primarily…

Methodology · Statistics 2025-12-10 Vincent Jeanselme , Chang Ho Yoon , Fabian Falck , Brian Tom , Jessica Barrett

Clinical time series data are critical for patient monitoring and predictive modeling. These time series are typically multivariate and often comprise hundreds of heterogeneous features from different data sources. The grouping of features…

Machine Learning · Computer Science 2025-11-12 Fedor Sergeev , Manuel Burger , Polina Leshetkina , Vincent Fortuin , Gunnar Rätsch , Rita Kuznetsova

Despite the constant development of new bias mitigation methods for machine learning, no method consistently succeeds, and a fundamental question remains unanswered: when and why do bias mitigation techniques fail? In this paper, we…

Machine Learning · Computer Science 2025-07-15 Anissa Alloula , Charles Jones , Ben Glocker , Bartłomiej W. Papież

Supervised deep learning models require significant amount of labeled data to achieve an acceptable performance on a specific task. However, when tested on unseen data, the models may not perform well. Therefore, the models need to be…

Computer Vision and Pattern Recognition · Computer Science 2024-01-01 Akshit Achara , Ram Krishna Pandey

Medical studies frequently require to extract the relationship between each covariate and the outcome with statistical confidence measures. To do this, simple parametric models are frequently used (e.g. coefficients of linear regression)…

Machine Learning · Computer Science 2023-05-02 Zachary Izzo , Ruishan Liu , James Zou

The ability to detect and adapt to changes in data distributions is crucial to maintain the accuracy and reliability of machine learning models. Detection is generally approached by observing the drift of model performance from a global…

Machine Learning · Computer Science 2025-05-22 Flavio Giobergia , Eliana Pastor , Luca de Alfaro , Elena Baralis

Machine learning (ML) is poised to drive innovations in clinical microbiomics, such as in disease diagnostics and prognostics. However, the successful implementation of ML in these domains necessitates the development of reproducible,…

Genomics · Quantitative Biology 2024-12-02 Natasha K. Dudek , Mariam Chakhvadze , Saba Kobakhidze , Omar Kantidze , Yuriy Gankin

When analyzing the behavior of machine learning algorithms, it is important to identify specific data subgroups for which the considered algorithm shows different performance with respect to the entire dataset. The intervention of domain…

Machine Learning · Computer Science 2021-08-18 Eliana Pastor , Luca de Alfaro , Elena Baralis

High model performance, on average, can hide that models may systematically underperform on subgroups of the data. We consider the tabular setting, which surfaces the unique issue of outcome heterogeneity - this is prevalent in areas such…

Machine Learning · Computer Science 2022-10-25 Nabeel Seedat , Jonathan Crabbé , Ioana Bica , Mihaela van der Schaar

Clinical data informs the personalization of health care with a potential for more effective disease management. In practice, this is achieved by subgrouping, whereby clusters with similar patient characteristics are identified and then…

Applications · Statistics 2024-04-17 Christof Naumzik , Alice Kongsted , Werner Vach , Stefan Feuerriegel

The task of subgroup discovery (SD) is to find interpretable descriptions of subsets of a dataset that stand out with respect to a target attribute. To address the problem of mining large numbers of redundant subgroups, subgroup set…

Machine Learning · Computer Science 2021-03-16 Hugo M. Proença , Peter Grünwald , Thomas Bäck , Matthijs van Leeuwen

In biomedical Subgroup Discovery, practitioners are interested in discovering interpretable and homogeneous subgroups within a group of patients. In this paper, assuming that healthy subjects (i.e., controls) share common but irrelevant…

Machine Learning · Computer Science 2026-05-21 Robin Louiset , Edouard Duchesnay , Benoit Dufumier , Antoine Grigis , Pietro Gori

Subgroup discovery is a descriptive and exploratory data mining technique to identify subgroups in a population that exhibit interesting behavior with respect to a variable of interest. Subgroup discovery has numerous applications in…

Machine Learning · Computer Science 2022-07-19 Ali Arab , Dev Arora , Jialin Lu , Martin Ester