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Quantitative analysis of the dynamics of tiny cellular and sub-cellular structures, known as particles, in time-lapse cell microscopy sequences requires the development of a reliable multi-target tracking method capable of tracking numerous…

Computer Vision and Pattern Recognition · Computer Science 2015-07-24 Seyed Hamid Rezatofighi , Stephen Gould , Ba Tuong Vo , Ba-Ngu Vo , Katarina Mele , Richard Hartley

Cells count become a challenging problem when the cells move in a continuous stream, and their boundaries are difficult for visual detection. To resolve this problem we modified the training and decision making processes using curriculum…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Danil Afonchikov , Elena Kornaeva , Irina Makovik , Alexey Kornaev

We focus on the biological problem of tracking organelles as they move through cells. In the past, most intracellular movements were recorded manually, however, the results are too incomplete to capture the full complexity of organelle…

Applications · Statistics 2015-09-17 Vasileios Maroulas , Andreas Nebenführ

In many multiobject tracking applications, including radar and sonar tracking, after prefiltering the received signal, measurement data is typically structured in cells. The cells, e.g., represent different range and bearing values.…

Signal Processing · Electrical Eng. & Systems 2024-06-04 Thomas Kropfreiter , Jason L. Williams , Florian Meyer

Biological cells, by definition, are the basic units which contain the fundamental molecules of life of which all living things are composed. Understanding how they function and differentiating cells from one another therefore is of…

Signal Processing · Electrical Eng. & Systems 2021-01-07 Hassan Raji , Muhammad Tayyab , Jianye Sui , Seyed Reza Mahmoodi , Mehdi Javanmard

Applications, ranging from tracking molecular motion within cells to analyzing complex animal foraging behavior, require algorithms for associating a collection of spot-like particles in one image with particles contained in another image.…

Quantitative Methods · Quantitative Biology 2013-04-23 Alexander Mont , Aubrey V. Wiegel , Diego Krapf , Christopher P. Calderon

We propose a cell segmentation method for analyzing images of densely clustered cells. The method combines the strengths of marker-controlled watershed transformation and a convolutional neural network (CNN). We demonstrate the method…

Image and Video Processing · Electrical Eng. & Systems 2020-04-06 Filip Lux , Petr Matula

Cell tracking enables data extraction from time-lapse "cell movies" and promotes modeling biological processes at the single-cell level. We introduce a new fully automated computational strategy to track accurately cells across frames in…

Computer Vision and Pattern Recognition · Computer Science 2017-06-23 Athanasios D. Balomenos , Panagiotis Tsakanikas , Elias S. Manolakos

Cell formation problem is among the first obstacles the designer of cellular production systems must overcome. This paper presents a critical analysis of the various criteria and constraints considered in the literature. The objective is to…

Computational Engineering, Finance, and Science · Computer Science 2020-07-23 Menouar Boulif , Karim Atif

Conventional cell tracking methods detect multiple cells in each frame (detection) and then associate the detection results in successive time-frames (association). Most cell tracking methods perform the association task independently from…

Computer Vision and Pattern Recognition · Computer Science 2020-02-27 Junya Hayashida , Kazuya Nishimura , Ryoma Bise

Conventional multi-stage cell tracking approaches rely heavily on detection or segmentation in each frame as a prerequisite, requiring substantial resources for high-quality segmentation masks and increasing the overall prediction time. To…

Image and Video Processing · Electrical Eng. & Systems 2025-10-14 Yaxuan Song , Jianan Fan , Heng Huang , Mei Chen , Weidong Cai

Single-object tracking is a well-known and challenging research topic in computer vision. Over the last two decades, numerous researchers have proposed various algorithms to solve this problem and achieved promising results. Recently,…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Janani Thangavel , Thanikasalam Kokul , Amirthalingam Ramanan , Subha Fernando

Image segmentation enables to extract quantitative measures from scans that can serve as imaging biomarkers for diseases. However, segmentation quality can vary substantially across scans, and therefore yield unfaithful estimates in the…

Image and Video Processing · Electrical Eng. & Systems 2020-11-03 J. Senapati , A. Guha Roy , S. Pölsterl , D. Gutmann , S. Gatidis , C. Schlett , A. Peters , F. Bamberg , C. Wachinger

Single-cell reference atlases are large-scale, cell-level maps that capture cellular heterogeneity within an organ using single cell genomics. Given their size and cellular diversity, these atlases serve as high-quality training data for…

Genomics · Quantitative Biology 2022-11-09 Jan Engelmann , Leon Hetzel , Giovanni Palla , Lisa Sikkema , Malte Luecken , Fabian Theis

Many important computer vision applications are naturally formulated as regression problems. Within medical imaging, accurate regression models have the potential to automate various tasks, helping to lower costs and improve patient…

Machine Learning · Computer Science 2023-11-08 Fredrik K. Gustafsson , Martin Danelljan , Thomas B. Schön

Automatic detection and tracking of cells in microscopy images are major applications of computer vision technologies in both biomedical research and clinical practice. Though machine learning methods are increasingly common in these…

Computer Vision and Pattern Recognition · Computer Science 2023-12-07 Nikomidisz Eftimiu , Michal Kozubek

Modern machine learning methods including deep learning have achieved great success in predictive accuracy for supervised learning tasks, but may still fall short in giving useful estimates of their predictive {\em uncertainty}. Quantifying…

Tracking all nuclei of an embryo in noisy and dense fluorescence microscopy data is a challenging task. We build upon a recent method for nuclei tracking that combines weakly-supervised learning from a small set of nuclei center point…

Computer Vision and Pattern Recognition · Computer Science 2022-08-25 Peter Hirsch , Caroline Malin-Mayor , Anthony Santella , Stephan Preibisch , Dagmar Kainmueller , Jan Funke

Semantic segmentation of microscopy cell images by deep learning is a significant technique. We considered that the Transformers, which have recently outperformed CNNs in image recognition, could also be improved and developed for cell…

Computer Vision and Pattern Recognition · Computer Science 2026-04-29 Hinako Mitsuoka , Kazuhiro Hotta

Cell counting in biomedical imaging is pivotal for various clinical applications, yet the interpretability of deep learning models in this domain remains a significant challenge. We propose a novel prototype-based method for interpretable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Abdurahman Ali Mohammed , Wallapak Tavanapong , Catherine Fonder , Donald S. Sakaguchi