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A universal and flexible design method for freeform surface that can modulate the distribution of an zero-\'etendue source to an arbitrary irradiance distribution is a significant challenge in the field of non-imaging optics. Current design…

Optics · Physics 2023-03-31 Haoqiang Wang , Zihan Zang , Yunpeng Xu , Yanjun Han , Hongtao Li , Yi Luo

In this work, we analyze a diffuse-interface model for tumor growth, subject to multiplicative white noises, posed on a bounded domain $\mathcal{O} \subset \mathbb{R}^d$, $d=2,3$. The model couples a stochastic incompressible convective…

Analysis of PDEs · Mathematics 2026-05-29 Kalpana Rawat , Kumarasamy Sakthivel

Our objective is the calibration of mathematical tumor growth models from a single multiparametric scan. The target problem is the analysis of preoperative Glioblastoma (GBM) scans. To this end, we present a fully automatic tumor-growth…

Medical Physics · Physics 2020-01-28 Klaudius Scheufele , Shashank Subramanian , George Biros

A two-dimensional free boundary model for the growth of multi-layer tumors has been proposed in [S. Cui, J. Escher: ARMA 191 (2009) 173-193] where the authors derive well-posedness in a functional analytic setting, the stationary solutions…

Analysis of PDEs · Mathematics 2012-04-12 Martin Kohlmann

Glioblastoma is among the most aggressive brain tumors in adults, characterized by patient-specific invasion patterns driven by the underlying brain microstructure. In this work, we present a proof-of-concept for a mathematical model of GBL…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 D. Cerrone , D. Riccobelli , S. Gazzoni , P. Vitullo , F. Ballarin , J. Falco , F. Acerbi , A. Manzoni , P. Zunino , P. Ciarletta

This paper presents a linear computational technique based on cubic trigonometric cubic B-splines for time fractional burgers' equation. The nonlinear advection term is approximated by a new linearization technique which is very efficient…

Numerical Analysis · Mathematics 2017-09-06 Muhammad Yaseen , Muhammad Abbas

A limited mobility nonequilibrium solid-on-solid dynamical model for kinetic surface growth is introduced as a simple description for the morphological evolution of a growing interface under random vapor deposition and surface diffusion…

Statistical Mechanics · Physics 2007-05-23 S. Das Sarma , P. Punyindu

Molecular data from tumor profiles is high dimensional. Tumor profiles can be characterized by tens of thousands of gene expression features. Due to the size of the gene expression feature set machine learning methods are exposed to noisy…

Machine Learning · Computer Science 2020-07-14 Martin Palazzo , Pierre Beauseroy , Patricio Yankilevich

Theoretical and computational tools that can be used in the clinic to predict neoplastic progression and propose individualized optimal treatment strategies to control cancer growth is desired. To develop such a predictive model, one must…

Cell Behavior · Quantitative Biology 2015-05-20 Salvatore Torquato

The ability to estimate how a tumor might evolve in the future could have tremendous clinical benefits, from improved treatment decisions to better dose distribution in radiation therapy. Recent work has approached the glioma growth…

Accurately modeling the spatiotemporal evolution of tumor morphology from baseline imaging is a pre-requisite for developing digital twin frameworks that can simulate disease progression and treatment response. Most existing approaches…

Image and Video Processing · Electrical Eng. & Systems 2025-10-01 Moinak Bhattacharya , Gagandeep Singh , Prateek Prasanna

In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalization of a phase field…

Analysis of PDEs · Mathematics 2019-06-27 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

In the present work, we investigate a model of the invasion of healthy tissue by cancer cells which is described by a system of nonlinear PDEs consisting of a cross-diffusion-reaction equation and two additional nonlinear ordinary…

Numerical Analysis · Mathematics 2023-07-18 Shahin Heydari , Petr Knobloch , Thoma Wick

In this contribution, the non-local, integro-partial differential system of equations proposed by Hillen et al. (Bull. Math. Biol. 75, 2013, no.1, 161-184) to account for the the tumor growth paradox (or the observation that some incomplete…

Analysis of PDEs · Mathematics 2019-03-13 Isai Padilla , Ramón G. Plaza

We study a free boundary problem modelling the growth of non-necrotic tumors with fluid-like tissues. The fluid velocity satisfies Stokes equations with a source determined by the proliferation rate of tumor cells which depends on the…

Analysis of PDEs · Mathematics 2008-06-10 Junde Wu , Shangbin Cui

Radiation therapy outcomes are decided by two key parameters, dose and timing, whose best values vary substantially across patients. This variability is especially critical in the treatment of brain cancer, where fractionated or staged…

Medical Physics · Physics 2025-06-24 Hao Peng , Steve Jiang , Robert Timmerman

The surroundings of a cancerous tumor impact how it grows and develops in humans. New data from early breast cancer patients contains information on the collagen fibers surrounding the tumorous tissue -- offering hope of finding additional…

Applications · Statistics 2022-06-30 Sean Kent , Menggang Yu

Radiation Therapy (XRT) is one of the most common cancer treatment methods. In this paper, a new mathematical model is proposed for the population dynamics of heterogeneous tumor cells following external beam radiation treatment. According…

Quantitative Methods · Quantitative Biology 2018-01-23 Amin Oroji , Shantia Yarahmadian , Sarkhosh Seddighi , Mohd Omar

In this paper, an innovative microwave imaging (MI) approach for breast tumor diagnosis is proposed that employs a differential formulation of the inverse scattering problem (ISP) at hand to exploit arbitrary-fidelity priors on the…

Signal Processing · Electrical Eng. & Systems 2024-01-08 Francesco Zardi , Luca Tosi , Marco Salucci , Andrea Massa

In this article, we study the numerical solution of the one dimensional nonlinear sine-Gordon by using the modified cubic B-spline differential quadrature method. The scheme is a combination of a modified cubic B spline basis function and…

Numerical Analysis · Mathematics 2014-10-03 H. S. Shukla , Mohammad Tamsir , Vineet K. Srivastava
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