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Recent advancements in machine learning (ML) are transforming the field of structural biology. For example, AlphaFold, a groundbreaking neural network for protein structure prediction, has been widely adopted by researchers. The…

Large language models (LLMs) excel at handling human queries, but they can occasionally generate flawed or unexpected responses. Understanding their internal states is crucial for understanding their successes, diagnosing their failures,…

Computation and Language · Computer Science 2025-02-24 Xuansheng Wu , Jiayi Yuan , Wenlin Yao , Xiaoming Zhai , Ninghao Liu

Vision-language models encode images and text in a joint space, minimizing the distance between corresponding image and text pairs. How are language and images organized in this joint space, and how do the models encode meaning and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Isabel Papadimitriou , Huangyuan Su , Thomas Fel , Sham Kakade , Stephanie Gil

While sparse autoencoders (SAEs) successfully extract interpretable features from language models, applying them to audio generation faces unique challenges: audio's dense nature requires compression that obscures semantic meaning, and…

Machine Learning · Computer Science 2025-10-31 Nathan Paek , Yongyi Zang , Qihui Yang , Randal Leistikow

Sparse autoencoders (SAEs) are used to decompose neural network activations into human-interpretable features. Typically, features learned by a single SAE are used for downstream applications. However, it has recently been shown that SAEs…

Machine Learning · Computer Science 2025-05-23 Soham Gadgil , Chris Lin , Su-In Lee

The mechanisms behind multilingual capabilities in Large Language Models (LLMs) have been examined using neuron-based or internal-activation-based methods. However, these methods often face challenges such as superposition and layer-wise…

Computation and Language · Computer Science 2025-05-28 Boyi Deng , Yu Wan , Yidan Zhang , Baosong Yang , Fuli Feng

Sparse autoencoders (SAEs) have emerged as a powerful technique for decomposing language model representations into interpretable features. Current interpretation methods infer feature semantics from activation patterns, but overlook that…

Machine Learning · Computer Science 2026-02-02 Yiting Liu , Zhi-Hong Deng

Fine-tuning Pre-trained protein language models (PLMs) has emerged as a prominent strategy for enhancing downstream prediction tasks, often outperforming traditional supervised learning approaches. As a widely applied powerful technique in…

Computation and Language · Computer Science 2024-04-24 Yang Tan , Mingchen Li , Bingxin Zhou , Bozitao Zhong , Lirong Zheng , Pan Tan , Ziyi Zhou , Huiqun Yu , Guisheng Fan , Liang Hong

While sparse autoencoders (SAEs) have generated significant excitement, a series of negative results have added to skepticism about their usefulness. Here, we establish a conceptual distinction that reconciles competing narratives…

Machine Learning · Computer Science 2025-07-01 Kenny Peng , Rajiv Movva , Jon Kleinberg , Emma Pierson , Nikhil Garg

Sparse autoencoders (SAEs) have recently emerged as a powerful tool for interpreting the features learned by large language models (LLMs). By reconstructing features with sparsely activated networks, SAEs aim to recover complex superposed…

Machine Learning · Computer Science 2026-03-05 Jingyi Cui , Qi Zhang , Yifei Wang , Yisen Wang

Sparse Autoencoders (SAEs) have emerged as a promising solution for decomposing large language model representations into interpretable features. However, Paulo and Belrose (2025) have highlighted instability across different initialization…

Machine Learning · Computer Science 2025-06-24 Seonglae Cho , Harryn Oh , Donghyun Lee , Luis Eduardo Rodrigues Vieira , Andrew Bermingham , Ziad El Sayed

Sparse Autoencoders (SAEs) are widely employed for mechanistic interpretability and model steering. Within this context, steering is by design performed by means of decoding altered SAE intermediate representations. This procedure…

Machine Learning · Computer Science 2025-12-08 Antonio Bărbălau , Cristian Daniel Păduraru , Teodor Poncu , Alexandru Tifrea , Elena Burceanu

Speech holds promise as a cost-effective and non-invasive biomarker for neurological conditions such as Parkinson's disease (PD). While deep learning systems trained on raw audio can find subtle signals not available from hand-crafted…

Audio and Speech Processing · Electrical Eng. & Systems 2025-07-24 Peter Plantinga , Jen-Kai Chen , Roozbeh Sattari , Mirco Ravanelli , Denise Klein

Recent work on sparse autoencoders (SAEs) has shown promise in extracting interpretable features from neural networks and addressing challenges with polysemantic neurons caused by superposition. In this paper, we apply SAEs to the early…

Machine Learning · Computer Science 2024-09-10 Liv Gorton

Recovering meaningful concepts from language model activations is a central aim of interpretability. While existing feature extraction methods aim to identify concepts that are independent directions, it is unclear if this assumption can…

Protein structure prediction often hinges on multiple sequence alignments (MSAs), which underperform on low-homology and orphan proteins. We introduce PLAME, a lightweight MSA design framework that leverages evolutionary embeddings from…

Machine Learning · Computer Science 2025-09-29 Hanqun Cao , Xinyi Zhou , Zijun Gao , Chenyu Wang , Xin Gao , Zhi Zhang , Cesar de la Fuente-Nunez , Chunbin Gu , Ge Liu , Pheng-Ann Heng

The high-level concepts that a neural network uses to perform computation need not be aligned to individual neurons (Smolensky, 1986). Language model interpretability research has thus turned to techniques such as \textit{sparse…

Computation and Language · Computer Science 2026-02-02 Aryaman Arora , Zhengxuan Wu , Jacob Steinhardt , Sarah Schwettmann

Sparse autoencoders (SAEs) have recently emerged as a powerful tool for language model steering. Prior work has explored top-k SAE latents for steering, but we observe that many dimensions among the top-k latents capture non-semantic…

Computation and Language · Computer Science 2025-10-03 Jiaqing Xie

Sparse autoencoders (SAEs) are one of the main methods to interpret the inner workings of deep neural networks (DNNs), decomposing activations into higher-dimensional features. However, they exhibit critical shortcomings where a large…

Machine Learning · Computer Science 2026-05-19 Michał Brzozowski , Neo Christopher Chung

The ImageNet hierarchy provides a structured taxonomy of object categories, offering a valuable lens through which to analyze the representations learned by deep vision models. In this work, we conduct a comprehensive analysis of how vision…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Matthew Lyle Olson , Musashi Hinck , Neale Ratzlaff , Changbai Li , Phillip Howard , Vasudev Lal , Shao-Yen Tseng