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Although the biostatistical scientific literature publishes new methods at a very high rate, many of these developments are not trustworthy enough to be adopted by the scientific community. We propose a framework to think about how a piece…
Statistical analysis is an important tool to distinguish systematic from chance findings. Current statistical analyses rely on distributional assumptions reflecting the structure of some underlying model, which if not met lead to problems…
This article reviews how empirical research of exploratory search is conducted. We investigated aspects of interdisciplinarity, study settings and evaluation methodologies from a systematically selected sample of 231 publications from…
Empirical research plays a fundamental role in the machine learning domain. At the heart of impactful empirical research lies the development of clear research hypotheses, which then shape the design of experiments. The execution of…
We warn against a common but incomplete understanding of empirical research in machine learning that leads to non-replicable results, makes findings unreliable, and threatens to undermine progress in the field. To overcome this alarming…
A representative researcher has repeated opportunities for empirical research. To process findings, she must impose an "identifying assumption." She conducts research when the assumption is sufficiently plausible (taking into account both…
The study of associations and their causal explanations is a central research activity whose methodology varies tremendously across fields. Even within specialized subfields, comparisons across textbooks and journals reveals that the basics…
The tension between qualitative theorizing and quantitative methods is pervasive in the social sciences, and poses a constant challenge to empirical research. But in science studies as an interdisciplinary specialty, there are additional…
One can argue that one of the main roles of the subject of statistics is to characterize what the evidence in collected data says about questions of scientific interest. There are two broad questions that we will refer to as the estimation…
Topological models of empirical and formal inquiry are increasingly prevalent. They have emerged in such diverse fields as domain theory [1, 16], formal learning theory [18], epistemology and philosophy of science [10, 15, 8, 9, 2],…
Statistical modeling is a powerful tool for developing and testing theories by way of causal explanation, prediction, and description. In many disciplines there is near-exclusive use of statistical modeling for causal explanation and the…
Testing hypotheses is an issue of primary importance in the scientific research, as well as in many other human activities. Much clarification about it can be achieved if the process of learning from data is framed in a stochastic model of…
This paper serves as a literature review of methodology concerning the (modern) causal inference methods to address the causal estimand with observational/survey data that have been or will be used in social science research. Mainly, this…
The last decades saw dramatic progress in brain research. These advances were often buttressed by probing single variables to make circumscribed discoveries, typically through null hypothesis significance testing. New ways for generating…
Empirical studies on formal methods and tools are rare. In this paper, we provide guidelines for such studies. We mention their main ingredients and then define nine different study strategies (laboratory experiments with software and human…
Unlike the Probability Theory based on additivity, Statistical Inference seems to hesitate between "Additivity" and a so-called "Maxitivity" approach. After a brief overview of three types of principles for any (parametric) statistical…
In clinical research and clinical decision-making, it is important to know if a study changes or only supports the current standards of care for specific disease management. We define such a change as transformative and a support as…
Statistical inference as a formal scientific method to covert experience to knowledge has proven to be elusively difficult. While frequentist and Bayesian methodologies have been accepted in the contemporary era as two dominant schools of…
Within the biological, physical, and social sciences, there are two broad quantitative traditions: statistical and mathematical modeling. Both traditions have the common pursuit of advancing our scientific knowledge, but these traditions…
Public-use survey data are an important source of information for researchers in social science and health studies to build statistical models and make inferences on the target finite population. This paper presents two general inferential…