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Experiments have revealed a nontrivial cancer-inhibiting capability of liquid media treated by the plasma jet capable of forming thinly stratified self-organized patterns at a plasma-liquid interface. A pronounced cancer depressing activity…
Background: Biological effects of extra-low-frequency (ELF) magnetic fields (MFs) have lacked a credible mechanism of interaction between MFs and living material. Objectives: To examine the effect of ELF-MFs on cancer cells. Methods: Five…
Micro-environmental acidity is a common feature of the tumor. One of the causes behind tumor acidity is lactate production by hypoxic cells of the tumor. Hypoxia is a direct result of the establishment of oxygen gradients. It is commonly…
An inverse procedure is proposed and tested which aims at recovering the a priori unknown functional and structural information from global signals of living brains activity. To this end we consider a Leaky-Integrate and Fire (LIF) model…
Breast cancer is one of the most challenging global health problems among women. This study investigates the intricate breast tumor microenvironment (TME) dynamics utilizing data from Mammary-specific Polyomavirus Middle T Antigen…
The effectiveness of oncolytic virotherapy is significantly affected by several elements of the tumour microenvironment, which reduce the ability of the virus to infect cancer cells. In this work, we focus on the influence of hypoxia on…
Protein-protein interaction networks associated with diseases have gained prominence as an area of research. We investigate algebraic and topological indices for protein-protein interaction networks of 11 human cancers derived from the…
Bacterial cancer therapy exploits anaerobic bacteria's ability to target hypoxia tumor regions, yet the interactions among tumor growth, bacterial colonization, oxygen levels, immunosuppressive cytokines, and bacterial communication remain…
To simplify mathematical models of disease spread, we often assume equal contact rates among hosts, but real-world scenarios differ. Network-based frameworks help capture these complexities and structural variations in actual systems. We…
The cellular phenotype is described by a complex network of molecular interactions. Elucidating network properties that distinguish disease from the healthy cellular state is therefore of critical importance for gaining systems-level…
In the study of cancer evolution and therapeutic strategies, scientific evidence shows that a key dynamics lies in the tumor-environment interaction. In particular, oxygen concentration plays a central role in the determination of the…
In a mathematical model of interacting biological organisms, where external interventions may alter behavior over time, traditional models that assume fixed parameters usually do not capture the evolving dynamics. In oncology, this is…
We present a minimal non-Hermitian model where a topologically nontrivial complex energy spectrum is induced by inter-particle interactions. Our model consists of a one-dimensional chain with a dynamical non-Hermitian gauge field with…
Mitogen-activated protein kinase (MAPK) signaling pathways play an essential role in the transduction of environmental stimuli to the nucleus, thereby regulating a variety of cellular processes, including cell proliferation, differentiation…
A synfire chain is a simple neural network model which can propagate stable synchronous spikes called a pulse packet and widely researched. However how synfire chains coexist in one network remains to be elucidated. We have studied the…
We introduce the Hyperedge-triggered Hawkes (HTH) process for inferring higher-order interaction structure in multi-cellular systems from asynchronous event-time data. Beyond standard pairwise excitation, the HTH intensity includes a term…
We deduce a model for glioma invasion making use of DTI data and accounting for the dynamics of brain tissue being actively degraded by tumor cells via excessive acidity production, but also according to the local orientation of tissue…
We propose and study a class of parabolic-ODE models involving chemotaxis and haptotaxis of a species following signals indirectly produced by another, non-motile one. The setting is motivated by cancer invasion mediated by interactions…
Eukaryotic cells transmit information by signaling through complex networks of interacting proteins. Here we develop a theoretical and computational framework that relates the biophysics of protein-protein interactions (PPIs) within a…
The pathway of the oxygen evolution reaction at the Pt(111)/water interface is disclosed through constant Fermi level molecular dynamics. Upon the application of a positive bias potential H 2 O ads and OH ads adsorbates are found to arrange…