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Access to real clinical data is often restricted due to privacy obligations, creating significant barriers for healthcare research. Synthetic datasets provide a promising solution, enabling secure data sharing and model development.…

Machine Learning · Computer Science 2024-10-24 Nicholas I-Hsien Kuo , Blanca Gallego , Louisa Jorm

Data privacy is a critical challenge in modern medical workflows as the adoption of electronic patient records has grown rapidly. Stringent data protection regulations limit access to clinical records for training and integrating machine…

Healthcare research and development face significant obstacles due to data scarcity and stringent privacy regulations, such as HIPAA and the GDPR, restricting access to essential real-world medical data. These limitations impede innovation,…

Machine Learning · Computer Science 2025-10-17 Md Ibrahim Shikder Mahin , Md Shamsul Arefin , Md Tanvir Hasan

As a pragmatic data augmentation tool, data synthesis has generally returned dividends in performance for deep learning based medical image analysis. However, generating corresponding segmentation masks for synthetic medical images is…

Image and Video Processing · Electrical Eng. & Systems 2023-03-23 Xiaodan Xing , Giorgos Papanastasiou , Simon Walsh , Guang Yang

Kidneys are the filter of the human body. About 10% of the global population is thought to be affected by Chronic Kidney Disease (CKD), which causes kidney function to decline. To protect in danger patients from additional kidney damage,…

ML models in healthcare are typically evaluated using curated real-world EHR data. A key limitation of such evaluations is that they may fail to assess the robustness of ML models to changes in the data at deployment, which is a common…

Machine Learning · Computer Science 2026-05-12 Roben Delos Reyes , Daniel Capurro , Nicholas Geard

Chronic Kidney Disease (CKD) has infected almost 800 million people around the world. Around 1.7 million people die each year because of it. Detecting CKD in the initial stage is essential for saving millions of lives. Many researchers have…

Machine Learning · Computer Science 2022-03-04 Md. Taufiqul Haque Khan Tusar , Md. Touhidul Islam , Foyjul Islam Raju

Synthetic cardiac MRI (CMRI) generation has emerged as a promising strategy to overcome the scarcity of annotated medical imaging data. Recent advances in GANs, VAEs, diffusion probabilistic models, and flow-matching techniques aim to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Ishan Kumarasinghe , Dasuni Kawya , Madhura Edirisooriya , Isuri Devindi , Isuru Nawinne , Vajira Thambawita

AI systems in healthcare research have shown potential to increase patient throughput and assist clinicians, yet progress is constrained by limited access to real patient data. To address this issue, we present a zero-shot, knowledge-guided…

Although computer-aided diagnosis (CADx) and detection (CADe) systems have made significant progress in various medical domains, their application is still limited in specialized fields such as otorhinolaryngology. In the latter, current…

Image and Video Processing · Electrical Eng. & Systems 2025-08-11 Chiara Baldini , Kaisar Kushibar , Richard Osuala , Simone Balocco , Oliver Diaz , Karim Lekadir , Leonardo S. Mattos

$\textbf{Background:}$ At the onset of a pandemic, such as COVID-19, data with proper labeling/attributes corresponding to the new disease might be unavailable or sparse. Machine Learning (ML) models trained with the available data, which…

Individual patient data (IPD) are essential for statistical inference in clinical research. However, privacy concerns, high data-sharing costs, and restrictive access often make IPD unavailable. Conventional synthetic data generation…

Applications · Statistics 2025-09-23 Zixuan Zhao , Zexin Ren , Guannan Zhai , Feifang Hu , Will Ma , En Xie , Qian Shi

Enhancing reproducibility and data accessibility is essential to scientific research. However, ensuring data privacy while achieving these goals is challenging, especially in the medical field, where sensitive data are often commonplace.…

Methodology · Statistics 2025-09-24 Marta Cipriani , Lorenzo Di Rocco , Maria Puopolo , Marco Alfò

Causal inference is essential for developing and evaluating medical interventions, yet real-world medical datasets are often difficult to access due to regulatory barriers. This makes synthetic data a potentially valuable asset that enables…

Machine Learning · Computer Science 2025-10-22 Harry Amad , Zhaozhi Qian , Dennis Frauen , Julianna Piskorz , Stefan Feuerriegel , Mihaela van der Schaar

We provide new algorithms for two tasks relating to heterogeneous tabular datasets: clustering, and synthetic data generation. Tabular datasets typically consist of heterogeneous data types (numerical, ordinal, categorical) in columns, but…

Machine Learning · Computer Science 2024-04-22 Chandrani Kumari , Rahul Siddharthan

We study the behavior of a Time-Aware Long Short-Term Memory Autoencoder, a state-of-the-art method, in the context of learning latent representations from irregularly sampled patient data. We identify a key issue in the way such recurrent…

Machine Learning · Computer Science 2019-02-12 Duc Thanh Anh Luong , Varun Chandola

Ensuring the generalisability of clinical machine learning (ML) models across diverse healthcare settings remains a significant challenge due to variability in patient demographics, disease prevalence, and institutional practices. Existing…

Machine Learning · Computer Science 2025-04-30 Bradley Segal , Joshua Fieggen , David Clifton , Lei Clifton

Mixed-frequency data, where variables are observed at different temporal resolutions, commonly occur in economic and financial studies. Classical synthetic control methods (SCM) are ill-suited for such data, often necessitating aggregation…

Methodology · Statistics 2026-05-13 Lu Zhang , Shijin Gong , Xinyu Zhang

Analysis of multivariate healthcare time series data is inherently challenging: irregular sampling, noisy and missing values, and heterogeneous patient groups with different dynamics violating exchangeability. In addition, interpretability…

Machine Learning · Computer Science 2023-11-15 Onur Poyraz , Pekka Marttinen

Chronic kidney disease (CKD) is a gradual loss of renal function over time, and it increases the risk of mortality, decreased quality of life, as well as serious complications. The prevalence of CKD has been increasing in the last couple of…

Machine Learning · Computer Science 2020-11-18 Jinghe Zhang , Kamran Kowsari , Mehdi Boukhechba , James Harrison , Jennifer Lobo , Laura Barnes
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