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One of the most fundamental problems in causal inference is the estimation of a causal effect when variables are confounded. This is difficult in an observational study, because one has no direct evidence that all confounders have been…

Machine Learning · Statistics 2014-11-03 Ricardo Silva , Robin Evans

How can we understand classification decisions made by deep neural networks? Many existing explainability methods rely solely on correlations and fail to account for confounding, which may result in potentially misleading explanations. To…

Machine Learning · Computer Science 2020-03-02 Yash Goyal , Amir Feder , Uri Shalit , Been Kim

Conventional methods in causal effect inferencetypically rely on specifying a valid set of control variables. When this set is unknown or misspecified, inferences will be erroneous. We propose a method for inferring average causal effects…

Methodology · Statistics 2021-06-14 Ludvig Hult , Dave Zachariah

The discovery of discriminatory bias in human or automated decision making is a task of increasing importance and difficulty, exacerbated by the pervasive use of machine learning and data mining. Currently, discrimination discovery largely…

Computers and Society · Computer Science 2019-11-05 Bilal Qureshi , Faisal Kamiran , Asim Karim , Salvatore Ruggieri , Dino Pedreschi

We study causal effect estimation from a mixture of observational and interventional data in a confounded linear regression model with multivariate treatments. We show that the statistical efficiency in terms of expected squared error can…

Recently, interpretable machine learning has re-explored concept bottleneck models (CBM). An advantage of this model class is the user's ability to intervene on predicted concept values, affecting the downstream output. In this work, we…

Machine Learning · Computer Science 2024-10-29 Sonia Laguna , Ričards Marcinkevičs , Moritz Vandenhirtz , Julia E. Vogt

Methods that rely on proxies, without imposing strong parametric structure, are increasingly used to deal with unobserved variables in causal inference. One influential line of this work reconstructs latent distributions used to identify…

Methodology · Statistics 2026-05-12 Helen Guo , Ilya Shpitser , Elizabeth L. Ogburn

Causal inference has gained much popularity in recent years, with interests ranging from academic, to industrial, to educational, and all in between. Concurrently, the study and usage of neural networks has also grown profoundly (albeit at…

Machine Learning · Statistics 2024-05-07 Demetrios Papakostas , Andrew Herren , P. Richard Hahn , Francisco Castillo

When making treatment selection decisions, it is essential to include a causal effect estimation analysis to compare potential outcomes under different treatments or controls, assisting in optimal selection. However, merely estimating…

Machine Learning · Statistics 2024-10-08 Sherly Alfonso-Sánchez , Kristina P. Sendova , Cristián Bravo

Deep learning models trained on extensive Electronic Health Records (EHR) data have achieved high accuracy in diagnosis prediction, offering the potential to assist clinicians in decision-making and treatment planning. However, these models…

Artificial Intelligence · Computer Science 2025-09-30 Xiaoxue Han , Pengfei Hu , Jun-En Ding , Chang Lu , Feng Liu , Yue Ning

In this paper we study approaches for dealing with treatment when developing a clinical prediction model. Analogous to the estimand framework recently proposed by the European Medicines Agency for clinical trials, we propose a…

We address the problem of causal effect estimation where hidden confounders are present, with a focus on two settings: instrumental variable regression with additional observed confounders, and proxy causal learning. Our approach uses a…

Machine Learning · Computer Science 2025-03-12 Haotian Sun , Antoine Moulin , Tongzheng Ren , Arthur Gretton , Bo Dai

Causal treatment effect estimation is a key problem that arises in a variety of real-world settings, from personalized medicine to governmental policy making. There has been a flurry of recent work in machine learning on estimating causal…

Machine Learning · Computer Science 2020-10-22 Niki Kilbertus , Matt J. Kusner , Ricardo Silva

Estimating causal effects from observational data informs us about which factors are important in an autonomous system, and enables us to take better decisions. This is important because it has applications in selecting a treatment in…

Machine Learning · Computer Science 2021-10-29 Plabon Shaha , Talha Islam Zadid , Ismat Rahman , Md. Mosaddek Khan

Causal inference is fundamental to empirical scientific discoveries in natural and social sciences; however, in the process of conducting causal inference, data management problems can lead to false discoveries. Two such problems are (i)…

Databases · Computer Science 2023-05-16 Brit Youngmann , Michael Cafarella , Babak Salimi , Anna Zeng

Causal inference from observational data can be viewed as a missing data problem arising from a hypothetical population-scale randomized trial matched to the observational study. This links a target trial protocol with a corresponding…

Methodology · Statistics 2022-07-27 Andrew Yiu , Edwin Fong , Stephen Walker , Chris Holmes

Improving public policy is one of the key roles of governments, and they can do this in an evidence-based way using administrative data. Causal inference for observational data improves on current practice of using descriptive or predictive…

Applications · Statistics 2023-01-18 Elena Tartaglia , Peter Rankin

Explaining the decisions of black-box models is a central theme in the study of trustworthy ML. Numerous measures have been proposed in the literature; however, none of them take an axiomatic approach to causal explainability. In this work,…

Machine Learning · Computer Science 2024-02-20 Gagan Biradar , Vignesh Viswanathan , Yair Zick

Discovering the causal effect of a decision is critical to nearly all forms of decision-making. In particular, it is a key quantity in drug development, in crafting government policy, and when implementing a real-world machine learning…

Machine Learning · Computer Science 2020-03-04 Limor Gultchin , Matt J. Kusner , Varun Kanade , Ricardo Silva

This work extends causal inference with stochastic confounders. We propose a new approach to variational estimation for causal inference based on a representer theorem with a random input space. We estimate causal effects involving latent…

Machine Learning · Statistics 2021-01-26 Thanh Vinh Vo , Pengfei Wei , Wicher Bergsma , Tze-Yun Leong