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Genomic phenotypes, such as DNA methylation and chromatin accessibility, can be used to characterize the transcriptional and regulatory activity of DNA within a cell. Recent technological advances have made it possible to measure such…

Methodology · Statistics 2016-11-15 Jean Morrison , Noah Simon , Daniela Witten

Batch normalization (BN) is a ubiquitous operation in deep neural networks, primarily used to improve stability and regularization during training. BN centers and scales feature maps using sample means and variances, which are naturally…

Machine Learning · Statistics 2026-02-04 Sofia Ivolgina , P. Thomas Fletcher , Baba C. Vemuri

Graph neural networks (GNNs) have emerged as powerful tools for learning protein structures by capturing spatial relationships at the residue level. However, existing GNN-based methods often face challenges in learning multiscale…

Machine Learning · Computer Science 2026-02-03 Shih-Hsin Wang , Yuhao Huang , Taos Transue , Justin Baker , Jonathan Forstater , Thomas Strohmer , Bao Wang

Linear shrinkage estimators of a covariance matrix --- defined by a weighted average of the sample covariance matrix and a pre-specified shrinkage target matrix --- are popular when analysing high-throughput molecular data. However, their…

Methodology · Statistics 2018-09-24 Harry Gray , Gwenaël G. R. Leday , Catalina A. Vallejos , Sylvia Richardson

The bug triaging process, an essential process of assigning bug reports to the most appropriate developers, is related closely to the quality and costs of software development. As manual bug assignment is a labor-intensive task, especially…

Software Engineering · Computer Science 2022-03-02 Hongrun Wu , Yutao Ma , Zhenglong Xiang , Chen Yang , Keqing He

Graphical models are commonly used to discover associations within gene or protein networks for complex diseases such as cancer. Most existing methods estimate a single graph for a population, while in many cases, researchers are interested…

Clustering and community detection with multiple graphs have typically focused on aligned graphs, where there is a mapping between nodes across the graphs (e.g., multi-view, multi-layer, temporal graphs). However, there are numerous…

Social and Information Networks · Computer Science 2019-04-11 Guilherme Gomes , Vinayak Rao , Jennifer Neville

Functional graphical models explore dependence relationships of random processes. This is achieved through estimating the precision matrix of the coefficients from the Karhunen-Loeve expansion. This paper deals with the problem of…

Methodology · Statistics 2021-10-14 Ilias Moysidis , Bing Li

We define a general class of network formation models, Statistical Exponential Random Graph Models (SERGMs), that nest standard exponential random graph models (ERGMs) as a special case. We provide the first general results on when these…

Physics and Society · Physics 2014-06-26 Arun G. Chandrasekhar , Matthew O. Jackson

Estimation of intracellular gene networks has been a critical component of single-cell transcriptomic data analysis, which can provide crucial insights into the complex interplay between genes, facilitating the discovery of the biological…

Applications · Statistics 2026-01-12 Jingyuan Yang , Tao Li , Tianyi Wang , Shuangge Ma , Mengyun Wu

Multi-sourced datasets are common in studies of variable interactions, for example, individual-level fMRI integration, cross-domain recommendation, etc, where each source induces a related but distinct dependency structure. Joint learning…

Methodology · Statistics 2025-12-08 Shixiang Liu , Yanhang Zhang , Zhifan Li , Jianxin Yin

Graph convolutional networks (GCNs) can effectively capture the features of related nodes and improve the performance of the model. More attention is paid to employing GCN in Skeleton-Based action recognition. But existing methods based on…

Computer Vision and Pattern Recognition · Computer Science 2020-12-08 Tingwei Li , Ruiwen Zhang , Qing Li

Laplacian regularized stratified models (LRSM) are models that utilize the explicit or implicit network structure of the sub-problems as defined by the categorical features called strata (e.g., age, region, time, forecast horizon, etc.),…

Machine Learning · Statistics 2023-05-05 Ziheng Cheng , Junzi Zhang , Akshay Agrawal , Stephen Boyd

Graphs from complex systems often share a partial underlying structure across domains while retaining individual features. Thus, identifying common structures can shed light on the underlying signal, for instance, when applied to scientific…

Methodology · Statistics 2022-04-05 Katherine Tsai , Oluwasanmi Koyejo , Mladen Kolar

Joint saliency map (JSM) [1] was developed to assign high joint saliency values to the corresponding saliency structures (called Joint Saliency Structures, JSSs) but zero or low joint saliency values to the outliers (or mismatches) that are…

Computer Vision and Pattern Recognition · Computer Science 2013-04-04 Zhuangming Shen , Jiuai Sun , Hui Zhang , Binjie Qin

Joint models (JMs) for longitudinal and time-to-event data are an important class of biostatistical models in health and medical research. When the study population consists of heterogeneous subgroups, the standard JM may be inadequate and…

Methodology · Statistics 2024-10-31 Sida Chen , Danilo Alvares , Marco Palma , Jessica K. Barrett

We propose a heterogeneous graph mamba network (HGMN) as the first exploration in leveraging the selective state space models (SSSMs) for heterogeneous graph learning. Compared with the literature, our HGMN overcomes two major challenges:…

Machine Learning · Computer Science 2024-05-24 Zhenyu Pan , Yoonsung Jeong , Xiaoda Liu , Han Liu

Recent advances in Spatial Transcriptomics (ST) pair histology images with spatially resolved gene expression profiles, enabling predictions of gene expression across different tissue locations based on image patches. This opens up new…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Aniruddha Ganguly , Debolina Chatterjee , Wentao Huang , Jie Zhang , Alisa Yurovsky , Travis Steele Johnson , Chao Chen

This paper presents a novel method for structural data recognition using a large number of graph models. In general, prevalent methods for structural data recognition have two shortcomings: 1) Only a single model is used to capture…

Machine Learning · Computer Science 2020-04-15 Tomo Miyazaki , Shinichiro Omachi

Stochastic blockmodels (SBM) and their variants, $e.g.$, mixed-membership and overlapping stochastic blockmodels, are latent variable based generative models for graphs. They have proven to be successful for various tasks, such as…

Machine Learning · Computer Science 2019-05-15 Nikhil Mehta , Lawrence Carin , Piyush Rai