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Molecular dynamics (MD) simulations are essential tools in computational chemistry and drug discovery, offering crucial insights into dynamic molecular behavior. However, their utility is significantly limited by substantial computational…

Chemical Physics · Physics 2025-09-04 Bin Feng , Jiying Zhang , Xinni Zhang , Zijing Liu , Yu Li

Small integration time steps limit molecular dynamics (MD) simulations to millisecond time scales. Markov state models (MSMs) and equation-free approaches learn low-dimensional kinetic models from MD simulation data by performing…

Computational Physics · Physics 2020-07-03 Hythem Sidky , Wei Chen , Andrew L. Ferguson

Simulation is a widely used tool in robotics to reduce hardware consumption and gather large-scale data. Despite previous efforts to simulate optical tactile sensors, there remain challenges in efficiently synthesizing images and…

Robotics · Computer Science 2024-05-02 Yongqiang Zhao , Kun Qian , Boyi Duan , Shan Luo

Machine learning is a powerful tool for extracting valuable information and making various predictions from diverse datasets. Traditional machine learning algorithms rely on well-defined input and output variables; however, there are…

Machine Learning · Computer Science 2025-02-05 Anh T. Hoang , Zsolt J. Viharos

The evolution of molecular dynamics (MD) simulations has been intimately linked to that of computing hardware. For decades following the creation of MD, simulations have improved with computing power along the three principal dimensions of…

The embedded systems engineering industry faces increasing demands for more functionality, rapidly evolving components, and shrinking schedules. Abilities to quickly adapt to changes, develop products with safe design, minimize project…

Systems and Control · Computer Science 2010-10-21 Bernhard Fischer

The advancement of machine learning and the availability of large-scale reaction datasets have accelerated the development of data-driven models for computer-aided synthesis planning (CASP) in the past decade. Here, we detail the newest…

We describe and implement iMapD, a computer-assisted approach for accelerating the exploration of uncharted effective Free Energy Surfaces (FES), and more generally for the extraction of coarse-grained, macroscopic information from…

Molecular simulation is a scientific tool dealing with challenges in material science and biology. This is reflected in a permanent development and enhancement of algorithms within scientific simulation packages. Here, we present…

The Finite Element Method (FEM) is widely used in engineering and scientific computing, but its pre-processing, solver configuration, and post-processing stages are often time-consuming and require specialized knowledge. This paper proposes…

Machine Learning · Computer Science 2025-10-15 Tao Zhang , Zhenhai Liu , Yong Xin , Yongjun Jiao

Component-Based Development (CBD) is a popular approach to mitigating the costs of creating software systems. However, it is not clear to what extent the core component selection and adaptation activities of CBD can be implemented to…

Software Engineering · Computer Science 2022-05-11 Todd Wareham , Marieke Sweers

Molecular Density Functional Theory (MDFT) offers an efficient implicit- solvent method to estimate molecule solvation free-energies whereas conserving a fully molecular representation of the solvent. Even within a second order ap-…

Soft Condensed Matter · Physics 2014-06-12 Volodymyr P. Sergiievskyi , Guillaume Jeanmairet , Maximilien Levesque , Daniel Borgis

Meshfree simulation methods are emerging as compelling alternatives to conventional mesh-based approaches, particularly in the fields of Computational Fluid Dynamics (CFD) and continuum mechanics. In this publication, we provide a…

Machine Learning · Computer Science 2024-03-21 Paulami Banerjee , Mohan Padmanabha , Chaitanya Sanghavi , Isabel Michel , Simone Gramsch

A tutorial introduction to the technique of Molecular Dynamics (MD) is given, and some characteristic examples of applications are described. The purpose and scope of these simulations and the relation to other simulation methods is…

Disordered Systems and Neural Networks · Physics 2009-11-10 Kurt Binder , Jurgen Horbach , Walter Kob , Wolfgang Paul , Fathollah Varnik

We develop an online optimisation algorithm for in situ calibration of collision models in simulations of rarefied gas flows. The online optimised collision models are able to achieve similar accuracy to Direct Molecular Simulation (DMS) at…

Fluid Dynamics · Physics 2024-11-21 Nicholas Daultry Ball , Jonathan F. MacArt , Justin Sirignano

Developing modern systems software is a complex task that combines business logic programming and Software Performance Engineering (SPE). The later is an experimental and labor-intensive activity focused on optimizing the system for a given…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-06-05 Carlo Curino , Neha Godwal , Brian Kroth , Sergiy Kuryata , Greg Lapinski , Siqi Liu , Slava Oks , Olga Poppe , Adam Smiechowski , Ed Thayer , Markus Weimer , Yiwen Zhu

The introduction of accelerator devices such as graphics processing units (GPUs) has had profound impact on molecular dynamics simulations and has enabled order-of-magnitude performance advances using commodity hardware. To fully reap these…

Computational Physics · Physics 2020-10-28 Szilárd Páll , Artem Zhmurov , Paul Bauer , Mark Abraham , Magnus Lundborg , Alan Gray , Berk Hess , Erik Lindahl

Ab initio molecular dynamics (AIMD) based on density functional theory (DFT) has become a workhorse for studying the structure, dynamics, and reactions in condensed matter systems. Currently, AIMD simulations are primarily carried out at…

Chemical Physics · Physics 2025-06-10 Ritama Kar , Sagarmoy Mandal , Vaishali Thakkur , Bernd Meyer , Nisanth N. Nair

Multi-modal fusion is of great significance in neuroscience which integrates information from different modalities and can achieve better performance than uni-modal methods in downstream tasks. Current multi-modal fusion methods in brain…

Artificial Intelligence · Computer Science 2026-04-03 Rui Dong , Xiaotong Zhang , Jiaxing Li , Yueying Li , Jiayin Wei , Youyong Kong

Molecular Dynamics studies of chemical processes in solution are of great value in a wide spectrum of applications, which range from nano-technology to pharmaceutical chemistry. However, these calculations are affected by severe finite-size…

Chemical Physics · Physics 2015-04-20 Claudio Perego , Matteo Salvalaglio , Michele Parrinello
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