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Medical imaging datasets are inherently high dimensional with large variability and low sample sizes that limit the effectiveness of deep learning algorithms. Recently, generative adversarial networks (GANs) with the ability to synthesize…

Image and Video Processing · Electrical Eng. & Systems 2024-12-13 Apoorva Sikka , Skand Peri , Jitender Singh Virk , Usma Niyaz , Deepti R. Bathula

Alzheimer's disease (AD) diagnosis requires integrating neuroimaging with heterogeneous clinical evidence and reasoning under established criteria, yet most multimodal models remain opaque and weakly guideline-aligned. We present…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Qiuhui Chen , Yushan Deng , Xuancheng Yao , Yi Hong

The integration of multimodal medical imaging can provide complementary and comprehensive information for the diagnosis of Alzheimer's disease (AD). However, in clinical practice, since positron emission tomography (PET) is often missing,…

Computational Engineering, Finance, and Science · Computer Science 2024-12-03 Fuyou Mao , Lixin Lin , Ming Jiang , Dong Dai , Chao Yang , Hao Zhang , Yan Tang

Alzheimer's disease, a neurodegenerative disorder, is associated with neural, genetic, and proteomic factors while affecting multiple cognitive and behavioral faculties. Traditional AD prediction largely focuses on univariate disease…

Early detection of Alzheimer's disease (AD) and identification of potential risk/beneficial factors are important for planning and administering timely interventions or preventive measures. In this paper, we learn a disease model for AD…

Machine Learning · Computer Science 2018-12-04 Parvathy Sudhir Pillai , Tze-Yun Leong

Alzheimer s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, where early detection is essential for timely intervention and improved patient outcomes. Traditional diagnostic methods are…

The deployment and application of Large Language Models (LLMs) is hindered by their memory inefficiency, computational demands, and the high costs of API inferences. Traditional distillation methods, which transfer the capabilities of LLMs…

Computation and Language · Computer Science 2024-11-21 Yifei Zhang , Bo Pan , Chen Ling , Yuntong Hu , Liang Zhao

Alzheimer's disease (AD) is a common form of dementia that severely impacts patient health. As AD impairs the patient's language understanding and expression ability, the speech of AD patients can serve as an indicator of this disease. This…

Audio and Speech Processing · Electrical Eng. & Systems 2023-07-07 Hongmin Cai , Xiaoke Huang , Zhengliang Liu , Wenxiong Liao , Haixing Dai , Zihao Wu , Dajiang Zhu , Hui Ren , Quanzheng Li , Tianming Liu , Xiang Li

The increased amount of multi-modal medical data has opened the opportunities to simultaneously process various modalities such as imaging and non-imaging data to gain a comprehensive insight into the disease prediction domain. Recent…

Machine Learning · Computer Science 2021-11-24 Mahsa Ghorbani , Mojtaba Bahrami , Anees Kazi , Mahdieh SoleymaniBaghshah , Hamid R. Rabiee , Nassir Navab

Deep learning (DL) has been used in the automatic diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) with brain imaging data. However, previous methods have not fully exploited the relation between brain image and…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Luoyao Kang , Haifan Gong , Xiang Wan , Haofeng Li

In medical vision, different imaging modalities provide complementary information. However, in practice, not all modalities may be available during inference or even training. Previous approaches, e.g., knowledge distillation or image…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Aishik Konwer , Xiaoling Hu , Joseph Bae , Xuan Xu , Chao Chen , Prateek Prasanna

Multiple modalities of biomarkers have been proved to be very sensitive in assessing the progression of Alzheimer's disease (AD), and using these modalities and machine learning algorithms, several approaches have been proposed to assist in…

Machine Learning · Statistics 2017-12-05 Chen Fang , Panuwat Janwattanapong , Chunfei Li , Malek Adjouadi

Early and accurate detection of Alzheimer's disease (AD) is crucial for enabling timely intervention and improving outcomes. However, developing reliable machine learning (ML) models for AD diagnosis is challenging due to limited labeled…

Machine Learning · Computer Science 2025-11-27 Abolfazl Moslemi , Hossein Peyvandi

A large number of papers have introduced novel machine learning and feature extraction methods for automatic classification of AD. However, they are difficult to reproduce because key components of the validation are often not readily…

Medical image anomaly detection faces unique challenges due to subtle, heterogeneous anomalies embedded in complex anatomical structures. Through systematic Grad-CAM analysis, we reveal that discriminative activation maps fail on medical…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Xijun Lu , Hongying Liu , Fanhua Shang , Yanming Hui , Liang Wan

Machine learning approaches for Alzheimer's disease (AD) diagnosis face a fundamental challenges. Clinical assessments are expensive and invasive, leaving ground truth labels available for only a fraction of neuroimaging datasets. We…

Machine Learning · Computer Science 2026-03-23 Alireza Moayedikia , Sara Fin

The success of deep convolutional neural networks is partially attributed to the massive amount of annotated training data. However, in practice, medical data annotations are usually expensive and time-consuming to be obtained. Considering…

Image and Video Processing · Electrical Eng. & Systems 2020-10-06 Kang Li , Lequan Yu , Shujun Wang , Pheng-Ann Heng

Alzheimer's Disease (AD) is one of the most concerned neurodegenerative diseases. In the last decade, studies on AD diagnosis attached great significance to artificial intelligence (AI)-based diagnostic algorithms. Among the diverse…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Yechong Huang , Jiahang Xu , Yuncheng Zhou , Tong Tong , Xiahai Zhuang , the Alzheimer's Disease Neuroimaging Initiative

Multispectral pedestrian detection has been shown to be effective in improving performance within complex illumination scenarios. However, prevalent double-stream networks in multispectral detection employ two separate feature extraction…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Zizhao Chen , Yeqiang Qian , Xiaoxiao Yang , Chunxiang Wang , Ming Yang

Accurate diagnosis of Alzheimer's disease (AD) requires effectively integrating multimodal data and clinical expertise. However, existing methods often struggle to fully utilize multimodal information and lack structured mechanisms to…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Qiuhui Chen , Jintao Wang , Gang Wang , Yi Hong