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With the rapid advancements in large language model (LLM) technology and the emergence of bioinformatics-specific language models (BioLMs), there is a growing need for a comprehensive analysis of the current landscape, computational…

Large language models (LLMs) offer significant potential to accelerate systematic literature reviews (SLRs), yet current approaches often rely on brittle, manually crafted prompts that compromise reliability and reproducibility. This…

Computation and Language · Computer Science 2025-09-03 Teo Susnjak

The reasoning abilities of Large Language Models (LLMs) are attracting increasing attention. In this work, we focus on causal reasoning and address the task of establishing causal relationships based on correlation information, a highly…

Computation and Language · Computer Science 2024-12-19 Eleni Sgouritsa , Virginia Aglietti , Yee Whye Teh , Arnaud Doucet , Arthur Gretton , Silvia Chiappa

The proliferation of Large Language Models (LLMs) has introduced critical security challenges, where adversarial actors can manipulate input prompts to cause significant harm and circumvent safety alignments. These prompt-based attacks…

A Large Language Model (LLM) represents a cutting-edge artificial intelligence model that generates coherent content, including grammatically precise sentences, human-like paragraphs, and syntactically accurate code snippets. LLMs can play…

Software Engineering · Computer Science 2023-12-11 Robson Santos , Italo Santos , Cleyton Magalhaes , Ronnie de Souza Santos

Large Language Models (LLMs), with their remarkable task-handling capabilities and innovative outputs, have catalyzed significant advancements across a spectrum of fields. However, their proficiency within specialized domains such as…

Quantitative Methods · Quantitative Biology 2024-03-05 Yin Fang , Xiaozhuan Liang , Ningyu Zhang , Kangwei Liu , Rui Huang , Zhuo Chen , Xiaohui Fan , Huajun Chen

Context: The emergence of Large Language Models (LLMs) has significantly transformed Software Engineering (SE) by providing innovative methods for analyzing software repositories. Objectives: Our objective is to establish a practical…

Software Engineering · Computer Science 2024-12-13 Vincenzo de Martino , Joel Castaño , Fabio Palomba , Xavier Franch , Silverio Martínez-Fernández

Large language models (LLMs) can be used as accessible and intelligent chatbots by constructing natural language queries and directly inputting the prompt into the large language model. However, different prompt' constructions often lead to…

Computation and Language · Computer Science 2023-12-14 Jinta Weng , Jiarui Zhang , Yue Hu , Daidong Fa , Xiaofeng Xuand , Heyan Huang

Large language models (LLMs) are rapidly transforming materials science. This review examines recent LLM applications across the materials discovery pipeline, focusing on three key areas: mining scientific literature , predictive modelling,…

Computation and Language · Computer Science 2025-11-17 Fengxu Yang , Weitong Chen , Jack D. Evans

Coreference resolution in biomedical texts presents unique challenges due to complex domain-specific terminology, high ambiguity in mention forms, and long-distance dependencies between coreferring expressions. In this work, we present a…

Computation and Language · Computer Science 2025-10-30 Nourah M Salem , Elizabeth White , Michael Bada , Lawrence Hunter

In this paper, we propose a novel prompting approach aimed at enhancing the ability of Large Language Models (LLMs) to generate accurate Python code. Specifically, we introduce a prompt template designed to improve the quality and…

Software Engineering · Computer Science 2025-06-16 Rogelio Cruz , Jonatan Contreras , Francisco Guerrero , Ezequiel Rodriguez , Carlos Valdez , Citlali Carrillo

Large Language Models (LLMs) are increasingly adopted for applications in healthcare, reaching the performance of domain experts on tasks such as question answering and document summarisation. Despite their success on these tasks, it is…

Computation and Language · Computer Science 2025-05-20 Aishik Nagar , Viktor Schlegel , Thanh-Tung Nguyen , Hao Li , Yuping Wu , Kuluhan Binici , Stefan Winkler

Large Language Models (LLMs) have significantly advanced software engineering (SE) tasks, with prompt engineering techniques enhancing their performance in code-related areas. However, the rapid development of foundational LLMs such as the…

Software Engineering · Computer Science 2024-11-05 Guoqing Wang , Zeyu Sun , Zhihao Gong , Sixiang Ye , Yizhou Chen , Yifan Zhao , Qingyuan Liang , Dan Hao

Prompt engineering is essential for optimizing large language models (LLMs), yet the link between prompt structures and task performance remains underexplored. This work introduces an evolutionary approach that combines context-free grammar…

Computation and Language · Computer Science 2025-04-22 Gabriel Machado Santos , Rita Maria da Silva Julia , Marcelo Zanchetta do Nascimento

Large Language Models (LLMs) are widely used in Automated Essay Scoring (AES) due to their ability to capture semantic meaning. Traditional fine-tuning approaches required technical expertise, limiting accessibility for educators with…

Computation and Language · Computer Science 2025-05-01 Kaixun Yang , Mladen Raković , Dragan Gašević , Guanliang Chen

Recent work on extending coreference resolution across domains and languages relies on annotated data in both the target domain and language. At the same time, pre-trained large language models (LMs) have been reported to exhibit strong…

Computation and Language · Computer Science 2023-11-16 Nghia T. Le , Alan Ritter

This paper demonstrates that language models are strong structure-based protein designers. We present LM-Design, a generic approach to reprogramming sequence-based protein language models (pLMs), that have learned massive sequential…

Machine Learning · Computer Science 2023-02-10 Zaixiang Zheng , Yifan Deng , Dongyu Xue , Yi Zhou , Fei YE , Quanquan Gu

Large language models (LLMs) are increasingly utilized in various complex reasoning tasks due to their excellent instruction following capability. However, the model's performance is highly dependent on the open-ended characteristics of the…

Computation and Language · Computer Science 2026-04-28 Zhenzhen Huang , Chaoning Zhang , Fachrina Dewi Puspitasari , Jiaquan Zhang , Yitian Zhou , Shuxu Chen , Yang Yang

This survey reviews how large language models (LLMs) are transforming synthetic training data generation in both natural language and code domains. By producing artificial but task-relevant examples, these models can significantly augment…

Computation and Language · Computer Science 2025-11-21 Mihai Nadas , Laura Diosan , Andreea Tomescu

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

Artificial Intelligence · Computer Science 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang