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Large language models (LLMs) such as ChatGPT have gained considerable interest across diverse research communities. Their notable ability for text completion and generation has inaugurated a novel paradigm for language-interfaced problem…

Quantitative Methods · Quantitative Biology 2024-02-22 Hengchuang Yin , Zhonghui Gu , Fanhao Wang , Yiparemu Abuduhaibaier , Yanqiao Zhu , Xinming Tu , Xian-Sheng Hua , Xiao Luo , Yizhou Sun

Large language models (LLMs) can perform recommendation tasks by taking prompts written in natural language as input. Compared to traditional methods such as collaborative filtering, LLM-based recommendation offers advantages in handling…

Information Retrieval · Computer Science 2025-07-21 Genki Kusano , Kosuke Akimoto , Kunihiro Takeoka

Large Language Models (LLMs) have demonstrated their transformative potential across numerous disciplinary studies, reshaping the existing research methodologies and fostering interdisciplinary collaboration. However, a systematic…

Computation and Language · Computer Science 2025-07-14 Lu Xiang , Yang Zhao , Yaping Zhang , Chengqing Zong

With the advent of Large Language Models (LLMs), generating rule-based data for real-world applications has become more accessible. Due to the inherent ambiguity of natural language and the complexity of rule sets, especially in long…

Computation and Language · Computer Science 2025-04-21 Teng Wang , Zhenqi He , Wing-Yin Yu , Xiaojin Fu , Xiongwei Han

Large language models (LLMs) have shown remarkable capabilities in general domains, but their application to multi-omics biology remains underexplored. To address this gap, we introduce Biology-Instructions, the first large-scale…

In large language models (LLM)-based recommendation systems (LLM-RSs), accurately predicting user preferences by leveraging the general knowledge of LLMs is possible without requiring extensive training data. By converting recommendation…

Information Retrieval · Computer Science 2024-12-20 Genki Kusano , Kosuke Akimoto , Kunihiro Takeoka

Prevailing large language models (LLMs) are capable of human responses simulation through its unprecedented content generation and reasoning abilities. However, it is not clear whether and how to leverage LLMs to simulate field experiments.…

Artificial Intelligence · Computer Science 2024-08-20 Yaoyu Chen , Yuheng Hu , Yingda Lu

Large language models (LLMs) have demonstrated remarkable capabilities in solving complex open-domain tasks, guided by comprehensive instructions and demonstrations provided in the form of prompts. However, these prompts can be lengthy,…

Artificial Intelligence · Computer Science 2023-11-20 Cho-Jui Hsieh , Si Si , Felix X. Yu , Inderjit S. Dhillon

Our team participated in the BioASQ 2024 Task12b and Synergy tasks to build a system that can answer biomedical questions by retrieving relevant articles and snippets from the PubMed database and generating exact and ideal answers. We…

Computation and Language · Computer Science 2024-07-10 Wenxin Zhou , Thuy Hang Ngo

The emergence of Large Language Models (LLMs) has achieved tremendous success in the field of Natural Language Processing owing to diverse training paradigms that empower LLMs to effectively capture intricate linguistic patterns and…

Information Retrieval · Computer Science 2024-07-04 Lemei Zhang , Peng Liu , Yashar Deldjoo , Yong Zheng , Jon Atle Gulla

This comprehensive review delves into the pivotal role of prompt engineering in unleashing the capabilities of Large Language Models (LLMs). The development of Artificial Intelligence (AI), from its inception in the 1950s to the emergence…

Computation and Language · Computer Science 2025-06-18 Banghao Chen , Zhaofeng Zhang , Nicolas Langrené , Shengxin Zhu

Protein sequence design, determined by amino acid sequences, are essential to protein engineering problems in drug discovery. Prior approaches have resorted to evolutionary strategies or Monte-Carlo methods for protein design, but often…

Large language models have demonstrated outstanding performance on a wide range of tasks such as question answering and code generation. On a high level, given an input, a language model can be used to automatically complete the sequence in…

Computation and Language · Computer Science 2023-05-31 Luca Beurer-Kellner , Marc Fischer , Martin Vechev

The field of prompt engineering is becoming an essential phenomenon in artificial intelligence. It is altering how data scientists interact with large language models (LLMs) for analytics applications. This research paper shares empirical…

Digital Libraries · Computer Science 2026-02-03 Snehasish Paul , Rohit Kumar , Laxman Das

Multimodal large language models (MLLMs) equip pre-trained large-language models (LLMs) with visual capabilities. While textual prompting in LLMs has been widely studied, visual prompting has emerged for more fine-grained and free-form…

Large Language Models (LLMs) have emerged as powerful tools in various research domains. This article examines their potential through a literature review and firsthand experimentation. While LLMs offer benefits like cost-effectiveness and…

Human-Computer Interaction · Computer Science 2024-04-10 M. Namvarpour , A. Razi

The performance of large language models (LLMs) is significantly influenced by the quality of the prompts provided. In response, researchers have developed enormous prompt engineering strategies aimed at modifying the prompt text to enhance…

Computation and Language · Computer Science 2024-10-23 Zhiyuan He , Huiqiang Jiang , Zilong Wang , Yuqing Yang , Luna Qiu , Lili Qiu

Large Language Models (LLMs) have emerged as powerful candidates to inform clinical decision-making processes. While these models play an increasingly prominent role in shaping the digital landscape, two growing concerns emerge in…

Computation and Language · Computer Science 2024-04-24 Raphael Poulain , Hamed Fayyaz , Rahmatollah Beheshti

The rapid advancement of large language models (LLMs) has opened new boundaries in the extraction and synthesis of medical knowledge, particularly within evidence synthesis. This paper reviews the state-of-the-art applications of LLMs in…

This paper assesses the potential for large language models (LLMs) to serve as assistive tools in the creative writing process, by means of a single, in-depth case study. In the course of the study, we develop interactive and multi-voice…

Computation and Language · Computer Science 2023-12-08 Murray Shanahan , Catherine Clarke