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The use of causal language in observational studies has raised concerns about overstatement in scientific communication. While some argue that such language should be reserved for randomized controlled trials, others contend that rigorous…

Physics and Society · Physics 2025-08-18 Jun Wang , Bei Yu

This study explores the potential of natural language models, including large language models, to extract causal relations from medical texts, specifically from Clinical Practice Guidelines (CPGs). The outcomes causality extraction from…

Computation and Language · Computer Science 2024-07-16 Seethalakshmi Gopalakrishnan , Luciana Garbayo , Wlodek Zadrozny

Many causal claims, such as "sugar causes hyperactivity," are disputed or outdated. Yet research on causality extraction from text has almost entirely neglected counterclaims of causation. To close this gap, we conduct a thorough literature…

Computation and Language · Computer Science 2026-01-08 Tim Hagen , Niklas Deckers , Felix Wolter , Harrisen Scells , Martin Potthast

Hallucinations, the tendency for large language models to provide responses with factually incorrect and unsupported claims, is a serious problem within natural language processing for which we do not yet have an effective solution to…

Computation and Language · Computer Science 2026-05-08 Brandon C. Colelough , Davis Bartels , Dina Demner-Fushman

Background and Aims: The methods with which prediction models are usually developed mean that neither the parameters nor the predictions should be interpreted causally. However, when prediction models are used to support decision making,…

Methodology · Statistics 2021-01-25 Lijing Lin , Matthew Sperrin , David A. Jenkins , Glen P. Martin , Niels Peek

The causal capabilities of large language models (LLMs) are a matter of significant debate, with critical implications for the use of LLMs in societally impactful domains such as medicine, science, law, and policy. We conduct a "behavorial"…

Artificial Intelligence · Computer Science 2024-08-21 Emre Kıcıman , Robert Ness , Amit Sharma , Chenhao Tan

Causal learning is the cognitive process of developing the capability of making causal inferences based on available information, often guided by normative principles. This process is prone to errors and biases, such as the illusion of…

The validity of medical studies based on real-world clinical data, such as observational studies, depends on critical assumptions necessary for drawing causal conclusions about medical interventions. Many published studies are flawed…

Artificial Intelligence · Computer Science 2024-07-30 Ahmed Alaa , Rachael V. Phillips , Emre Kıcıman , Laura B. Balzer , Mark van der Laan , Maya Petersen

Clinical diagnosis requires answers that are accurate, verifiable, and explicitly grounded in official guidelines. While large language models excel at natural language processing, their tendency to hallucinate undermines their utility in…

Artificial Intelligence · Computer Science 2026-05-29 Navapat Nananukul , Mayank Kejriwal

Background: Causal relations in natural language (NL) requirements convey strong, semantic information. Automatically extracting such causal information enables multiple use cases, such as test case generation, but it also requires to…

Software Engineering · Computer Science 2022-01-21 Julian Frattini , Jannik Fischbach , Daniel Mendez , Michael Unterkalmsteiner , Andreas Vogelsang , Krzystof Wnuk

Causal learning is the cognitive process of developing the capability of making causal inferences based on available information, often guided by normative principles. This process is prone to errors and biases, such as the illusion of…

This study evaluates causal reasoning in large language models (LLMs) using 99 clinically grounded laboratory test scenarios aligned with Pearl's Ladder of Causation: association, intervention, and counterfactual reasoning. We examined…

Artificial Intelligence · Computer Science 2025-09-23 Balu Bhasuran , Mattia Prosperi , Karim Hanna , John Petrilli , Caretia JeLayne Washington , Zhe He

While large language models (LLMs) play increasingly significant roles in society, research shows they continue to generate content that reflects social bias against sensitive groups. Existing benchmarks effectively identify these biases,…

Computation and Language · Computer Science 2026-03-12 Tian Xie , Tongxin Yin , Vaishakh Keshava , Xueru Zhang , Siddhartha Reddy Jonnalagadda

Objective: The growing availability of large-scale observational clinical datasets and challenges in conducting randomized controlled trials have spurred enthusiasm in using causal machine learning (ML) for causal inference in observational…

Causal inference is one of the hallmarks of human intelligence. While the field of CausalNLP has attracted much interest in the recent years, existing causal inference datasets in NLP primarily rely on discovering causality from empirical…

Computation and Language · Computer Science 2024-04-18 Zhijing Jin , Jiarui Liu , Zhiheng Lyu , Spencer Poff , Mrinmaya Sachan , Rada Mihalcea , Mona Diab , Bernhard Schölkopf

Objective: Leveraging machine learning methods, we aim to extract both explicit and implicit cause-effect associations in patient-reported, diabetes-related tweets and provide a tool to better understand opinion, feelings and observations…

Large language models (LLMs) are increasingly used in domains where causal reasoning matters, yet it remains unclear whether their judgments reflect normative causal computation, human-like shortcuts, or brittle pattern matching. We…

Artificial Intelligence · Computer Science 2026-03-16 Hanna M. Dettki , Charley M. Wu , Bob Rehder

Many benchmarks for automated causal inference evaluate a system's performance based on a single numerical output, such as an Average Treatment Effect (ATE). This approach conflates two distinct steps in causal analysis: identification -…

Artificial Intelligence · Computer Science 2026-05-15 Ayush Sawarni , Jiyuan Tan , Vasilis Syrgkanis

Clinical practice guidelines (CPGs) encode evidence-based decision logic that clinicians apply by evaluating patient variables, conditional criteria, and recommendation rules. However, existing methods often use CPGs as free-text training…

Artificial Intelligence · Computer Science 2026-05-27 Yuhao Shen , Lang Cao , Simo Du , Yuqing Wang , Juexiao Zhou , Hao Peng , Yue Guo

Reliable causal inference is essential for making decisions in high-stakes areas like medicine, economics, and public policy. However, it remains unclear whether large language models (LLMs) can handle rigorous and trustworthy statistical…

Artificial Intelligence · Computer Science 2026-05-13 Jin Du , Li Chen , Xun Xian , An Luo , Fangqiao Tian , Ganghua Wang , Charles Doss , Xiaotong Shen , Jie Ding
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