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We introduce a multicrossmodal LLM-agent framework motivated by the growing volume and diversity of materials-science data ranging from high-resolution microscopy and dynamic simulation videos to tabular experiment logs and sprawling…

Materials Science · Physics 2025-05-22 Adib Bazgir , Rama chandra Praneeth Madugula , Yuwen Zhang

AI agents powered by large language models (LLMs) have shown strong capabilities in problem solving. Through combining many intelligent agents, multi-agent collaboration has emerged as a promising approach to tackle complex, multi-faceted…

Computation and Language · Computer Science 2024-12-10 Raphael Shu , Nilaksh Das , Michelle Yuan , Monica Sunkara , Yi Zhang

Despite their ability to understand chemical knowledge, large language models (LLMs) remain limited in their capacity to propose novel molecules with desired functions (e.g., drug-like properties). In addition, the molecules that LLMs…

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited…

Robotics · Computer Science 2025-07-03 Yibo Qiu , Zan Huang , Zhiyu Wang , Handi Liu , Yiling Qiao , Yifeng Hu , Shu'ang Sun , Hangke Peng , Ronald X Xu , Mingzhai Sun

Large language models (LLMs) have demonstrated their instruction-following capabilities and achieved powerful performance on various tasks. Inspired by their success, recent works in the molecular domain have led to the development of large…

Artificial Intelligence · Computer Science 2026-01-21 Jinyoung Park , Minseong Bae , Jeehye Na , Hyunwoo J. Kim

Large Language Models (LLMs) have recently demonstrated remarkable performance in general tasks across various fields. However, their effectiveness within specific domains such as drug development remains challenges. To solve these…

Artificial Intelligence · Computer Science 2024-10-16 Tengfei Ma , Xuan Lin , Tianle Li , Chaoyi Li , Long Chen , Peng Zhou , Xibao Cai , Xinyu Yang , Daojian Zeng , Dongsheng Cao , Xiangxiang Zeng

The discovery of novel small molecule drugs remains a critical scientific challenge with far-reaching implications for treating diseases and advancing human health. Traditional drug development--especially for small molecule…

Biomolecules · Quantitative Biology 2025-04-01 Bowen Gao , Yanwen Huang , Yiqiao Liu , Wenxuan Xie , Wei-Ying Ma , Ya-Qin Zhang , Yanyan Lan

Molecular editing and optimization are multi-step problems that require iteratively improving properties while keeping molecules chemically valid and structurally similar. We frame both tasks as sequential, tool-guided decisions and…

Artificial Intelligence · Computer Science 2025-12-25 Zhuo Yang , Yeyun Chen , Jiaqing Xie , Ben Gao , Shuaike Shen , Wanhao Liu , Liujia Yang , Beilun Wang , Tianfan Fu , Yuqiang Li

Chemical process optimization maximizes production efficiency and economic performance, but optimization algorithms, including gradient-based solvers, numerical methods, and parameter grid searches, become impractical when operating…

Machine Learning · Computer Science 2025-10-17 Tong Zeng , Srivathsan Badrinarayanan , Janghoon Ock , Cheng-Kai Lai , Amir Barati Farimani

Effort estimation is a crucial activity in agile software development, where teams collaboratively review, discuss, and estimate the effort required to complete user stories in a product backlog. Current practices in agile effort estimation…

Software Engineering · Computer Science 2025-09-19 Thanh-Long Bui , Hoa Khanh Dam , Rashina Hoda

Agents powered by advanced large language models (LLMs) have demonstrated impressive capabilities across diverse complex applications. Recently, Multi-Agent Systems (MAS), wherein multiple agents collaborate and communicate with each other,…

Multiagent Systems · Computer Science 2026-05-15 Shijun Li , Hilaf Hasson , Joydeep Ghosh

We propose a multimodal (vision-and-language) benchmark for cooperative and heterogeneous multi-agent learning. We introduce a benchmark multimodal dataset with tasks involving collaboration between multiple simulated heterogeneous robots…

Artificial Intelligence · Computer Science 2022-08-30 Vasu Sharma , Prasoon Goyal , Kaixiang Lin , Govind Thattai , Qiaozi Gao , Gaurav S. Sukhatme

We have seen remarkable progress in large language models (LLMs) empowered multi-agent systems solving complex tasks necessitating cooperation among experts with diverse skills. However, optimizing LLM-based multi-agent systems remains…

Artificial Intelligence · Computer Science 2025-08-08 Ming Shen , Raphael Shu , Anurag Pratik , James Gung , Yubin Ge , Monica Sunkara , Yi Zhang

Large language models (LLMs) have shown promising capabilities in visually interpreting medical time-series data. However, their general-purpose design can limit domain-specific precision, and the proprietary nature of many models poses…

Artificial Intelligence · Computer Science 2025-07-22 Huayu Li , Zhengxiao He , Xiwen Chen , Ci Zhang , Stuart F. Quan , William D. S. Killgore , Shu-Fen Wung , Chen X. Chen , Geng Yuan , Jin Lu , Ao Li

In an era defined by the explosive growth of data and rapid technological advancements, Multimodal Large Language Models (MLLMs) stand at the forefront of artificial intelligence (AI) systems. Designed to seamlessly integrate diverse data…

Large Language Models (LLMs) have achieved remarkable success and have been applied across various scientific fields, including chemistry. However, many chemical tasks require the processing of visual information, which cannot be…

Automated Machine Learning (AutoML) offers a promising approach to streamline the training of machine learning models. However, existing AutoML frameworks are often limited to unimodal scenarios and require extensive manual configuration.…

Machine Learning · Computer Science 2024-08-02 Daqin Luo , Chengjian Feng , Yuxuan Nong , Yiqing Shen

Large language models (LLMs) are powerful artificial intelligence (AI) tools transforming how research is conducted. However, their use in research has been met with skepticism, due to concerns about hallucinations, biases and potential…

Artificial Intelligence · Computer Science 2025-07-08 Ruian Ke , Ruy M. Ribeiro

Large Language Models (LLMs) have shown great promise in multilingual machine translation (MT), even with limited bilingual supervision. However, fine-tuning LLMs with parallel corpora presents major challenges, namely parameter…

Computation and Language · Computer Science 2026-05-26 Bo Li , Tianyu Dong , Shaolin Zhu , Deyi Xiong

Large Language Models (LLMs) have facilitated the definition of autonomous intelligent agents. Such agents have already demonstrated their potential in solving complex tasks in different domains. And they can further increase their…

Software Engineering · Computer Science 2025-06-30 Adem Ait , Javier Luis Cánovas Izquierdo , Jordi Cabot