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To test scientific theories and develop individualized treatment rules, researchers often wish to learn heterogeneous treatment effects that can be consistently found across diverse populations and contexts. We consider the problem of…

Methodology · Statistics 2026-05-01 Yi Zhang , Melody Huang , Kosuke Imai

Recent advances in differentially private deep learning have demonstrated that application of differential privacy, specifically the DP-SGD algorithm, has a disparate impact on different sub-groups in the population, which leads to a…

One of the major challenges in estimating conditional potential outcomes and conditional average treatment effects (CATE) is the presence of hidden confounders. Since testing for hidden confounders cannot be accomplished only with…

Machine Learning · Computer Science 2025-06-17 Ahmed Aloui , Juncheng Dong , Ali Hasan , Vahid Tarokh

In personalised decision making, evidence is required to determine whether an action (treatment) is suitable for an individual. Such evidence can be obtained by modelling treatment effect heterogeneity in subgroups. The existing…

Methodology · Statistics 2022-06-24 Jiuyong Li , Lin Liu , Shisheng Zhang , Saisai Ma , Thuc Duy Le , Jixue Liu

Many applications of machine learning, such as human health research, involve processing private or sensitive information. Privacy concerns may impose significant hurdles to collaboration in scenarios where there are multiple sites holding…

Machine Learning · Computer Science 2021-02-24 Hafiz Imtiaz , Jafar Mohammadi , Anand D. Sarwate

Estimating conditional average treatment effects (CATE) from observational data involves modeling decisions that differ from supervised learning, particularly concerning how to regularize model complexity. Previous approaches can be grouped…

Machine Learning · Computer Science 2026-02-03 Zhongyuan Liang , Lars van der Laan , Ahmed Alaa

When estimating heterogeneous treatment effects, missing outcome data can complicate treatment effect estimation, causing certain subgroups of the population to be poorly represented. In this work, we discuss this commonly overlooked…

Machine Learning · Statistics 2025-04-15 Matthew Pryce , Karla Diaz-Ordaz , Ruth H. Keogh , Stijn Vansteelandt

In the social and health sciences, researchers often make causal inferences using sensitive variables. These researchers, as well as the data holders themselves, may be ethically and perhaps legally obligated to protect the confidentiality…

Methodology · Statistics 2024-08-28 Sharmistha Guha , Jerome P. Reiter

Understanding treatment effect heterogeneity is crucial for reliable decision-making in treatment evaluation and selection. The conditional average treatment effect (CATE) is widely used to capture treatment effect heterogeneity induced by…

Methodology · Statistics 2026-04-14 Peng Wu , Peng Ding , Zhi Geng , Yue Liu

Estimation of conditional average treatment effects (CATEs) plays an essential role in modern medicine by informing treatment decision-making at a patient level. Several metalearners have been proposed recently to estimate CATEs in an…

Applications · Statistics 2022-09-07 Yizhe Xu , Nikolaos Ignatiadis , Erik Sverdrup , Scott Fleming , Stefan Wager , Nigam Shah

Some machine learning applications involve training data that is sensitive, such as the medical histories of patients in a clinical trial. A model may inadvertently and implicitly store some of its training data; careful analysis of the…

Machine Learning · Statistics 2017-03-06 Nicolas Papernot , Martín Abadi , Úlfar Erlingsson , Ian Goodfellow , Kunal Talwar

Differential Privacy (DP) is a well-established framework to quantify privacy loss incurred by any algorithm. Traditional DP formulations impose a uniform privacy requirement for all users, which is often inconsistent with real-world…

Cryptography and Security · Computer Science 2023-05-18 Syomantak Chaudhuri , Thomas A. Courtade

We present a technical case study on the Privacy-Enhancing Technologies (PETs) for Public Health Challenge, a collaborative effort to safely leverage sensitive private sector data for social impact, specifically pandemic management. The…

Cryptography and Security · Computer Science 2026-03-17 Avinash Laddha , Danil Mikhailov , Uyi Stewart

Adaptive experiment is widely adopted to estimate conditional average treatment effect (CATE) in clinical trials and many other scenarios. While the primary goal in experiment is to maximize estimation accuracy, due to the imperative of…

Methodology · Statistics 2024-02-06 Jiachun Li , Kaining Shi , David Simchi-Levi

To effectively optimize and personalize treatments, it is necessary to investigate the heterogeneity of treatment effects. With the wide range of users being treated over many online controlled experiments, the typical approach of manually…

Methodology · Statistics 2022-11-07 John Cai , Weinan Wang

Conditional Average Treatment Effect (CATE) estimation, at the heart of counterfactual reasoning, is a crucial challenge for causal modeling both theoretically and applicatively, in domains such as healthcare, sociology, or advertising.…

Machine Learning · Computer Science 2025-01-27 Armand Lacombe , Michèle Sebag

Conditional Generative Adversarial Networks (CGANs) exhibit significant potential in supervised learning model training by virtue of their ability to generate realistic labeled images. However, numerous studies have indicated the privacy…

Computer Vision and Pattern Recognition · Computer Science 2024-04-22 Zepeng Jiang , Weiwei Ni , Yifan Zhang

Estimating treatment effects conditional on observed covariates can improve the ability to tailor treatments to particular individuals. Doing so effectively requires dealing with potential confounding, and also enough data to adequately…

We propose a novel and systematic differentially private (DP) inference framework for non-Euclidean data. First, we design two types of DP mechanisms for the Fr\'echet mean and variance with i.i.d. Riemannian manifold-valued data, tailored…

Methodology · Statistics 2026-05-15 Yangdi Jiang , Xiaotian Chang , Qirui Hu

Machine learning models in health care are often deployed in settings where it is important to protect patient privacy. In such settings, methods for differentially private (DP) learning provide a general-purpose approach to learn models…

Machine Learning · Computer Science 2020-10-15 Vinith M. Suriyakumar , Nicolas Papernot , Anna Goldenberg , Marzyeh Ghassemi